Resources

Using GeneCopoeia FISH Probes in a CRISPR-mediated Genome Editing Workflow

  Qihong Xu, Meng Zhang, Xueming Xu, and Ed Davis Introduction Immortalized mammalian cell lines, while providing convenient model systems for biomedical and pharmaceutical research, often carry 3 or more copies of a chromosome or gene (Wistuba, et al., 1998;...
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Genome Editing: Applications For GeneCopoeia CRISPR sgRNA Libraries

  Ed Davis, Ph.D. Biomedical researchers are enjoying a Renaissance in functional genomics, which aims to use a wealth of DNA sequence information—most notably, the complete sequence of the human genome—to determine the natural roles of the genes...
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Genome Editing: HDR Donors For Gene Knockout, Mutagenesis, Tagging, and Safe Harbor Knock-in

  Ed Davis, Ph.D. Genome Editing—making specific changes at targeted genomic sites—is fundamentally important to researchers in biology and medicine (Bogdanove & Voytas, 2011; van der Oost, et al., 2013). Two popular genome editing technologies...
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Lentivirus: That’s My MOI, and I’m Sticking To It

  Ed Davis, Ph.D. Introduction Lentiviral vectors have proven invaluable for introducing genetic material into mammalian cells, either in culture or whole animals (reviewed in Mátrai, et al., 2010). Lentiviruses, primarily derived from human or feline...
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