All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

Immuno-oncology

Introduction

Immuno-oncology is a scientific field that studies the interactions between tumors and the immune system, revealing how tumors evade the immune surveillance and elimination, as well as how they exploit the mechanisms of the immune system to promote their growth and spread. Cancer immunotherapy, developed on the theoretical foundation of immuno-oncology, represents a revolutionary approach to treatment. It activates or enhances the patient’s own immune system to recognize and destroy cancer cells, fundamentally differing from traditional cancer treatments such as surgery, radiation, and chemotherapy. Cancer immunotherapy comes in a variety of forms, including targeted antibodies, cancer vaccines, adoptive cell transfer, tumor-infecting viruses, checkpoint inhibitors, cytokines, and adjuvants.

Application

The Immuno-oncology clone set can be used in GSRA technology to perform high-throughput screening of various transmembrane or secreted proteins interacting with target proteins.The Genome-Scale Receptor Array (GSRA) is a semi-automated gene expression and detection system invented by Prof. Lieping Chen’s team, which is used to rapidly detect protein-protein interactions. This clone set fuels a number of research results. Screening of ligand proteins for LAG-3, revealing the role of this LAG-3-FGL1 pathway in tumour immunity and therapy^[1]. Demonstrating that Siglec-15 inhibits antigen-specific T-cell responses in vitro and in vivo, and can serve as a potential target for cancer immunotherapy^[2]. Identifying IGFBP7 interacts with its receptor CD93, and subsequently demonstrated that this interaction contributes to abnormal tumor vasculature^[3]. And showing CD8α is critical for the maintenance of CD8+ T cells in a physiologically quiescent state in peripheral lymphoid organs^[4].

Reference

Wang, F., et al., Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell, 2018
Wang J, Sun J, Liu L N, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature medicine, 2019
Sun Y, Chen W, Torphy R J, et al. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science Translational Medicine, 2021
Zheng, L., et al., The CD8α-PILRα interaction maintains CD8+ T cell quiescence. Science, 2022

Clone set information

Cat. No.	Old Cat. No.	Species	Gene	Vector	Vector Type	Price
OC-GF012-M02	OC-HIO-M02	Human	6592	pReceiver-M02	Expression-ready Non-viral	Inquire
OC-GF012-M35	OC-HIO-M35	Human	6592	pReceiver-M35	Expression-ready Non-viral	Inquire
OC-GF012-M98	OC-HIO-M98	Human	6592	pReceiver-M98	Expression-ready Non-viral	Inquire
OC-GF012-Lv105	OC-HIO-Lv105	Human	6592	pReceiver-Lv105	Expression-ready Lentiviral	Inquire
OC-GF012-Lv242	OC-HIO-Lv242	Human	6592	pReceiver-Lv242	Expression-ready Lentiviral	Inquire
OC-GF012-GC	OC-HIO-GC	Human	6592	pDONR™ Vector	Gateway shuttle	Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.

Symbol	Accession	Species	Description	ORF length(bp)	Product ID
CNPY2	NM_001190991.3	Human	Homo sapiens canopy FGF signaling regulator 2 (CNPY2), transcript variant 2, mRNA.	255	GC-Z8498
PRNP	NM_001271561.3	Human	Homo sapiens prion protein (PRNP), transcript variant 2, mRNA.	222	GC-I1624
FDFT1	NM_004462.5	Human	Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), transcript variant 3, mRNA.	1254	GC-Z7539
FFAR3	NM_005304.5	Human	Homo sapiens free fatty acid receptor 3 (FFAR3), mRNA.	1041	GC-U0271
CNPY2	NM_014255.7	Human	Homo sapiens canopy FGF signaling regulator 2 (CNPY2), transcript variant 1, mRNA.	549	GC-U0561
KLK13	NM_015596.3	Human	Homo sapiens kallikrein related peptidase 13 (KLK13), transcript variant 1, mRNA.	834	GC-T1297
DTL	NM_016448.4	Human	Homo sapiens denticleless E3 ubiquitin protein ligase homolog (DTL), transcript variant 1, mRNA.	2193	GC-A3689
F11R	NM_016946.6	Human	Homo sapiens F11 receptor (F11R), transcript variant 1, mRNA.	900	GC-U0777
OLFML3	NM_020190.5	Human	Homo sapiens olfactomedin like 3 (OLFML3), transcript variant 1, mRNA.	1221	GC-V1261
C1QTNF1	NM_030968.5	Human	Homo sapiens C1q and TNF related 1 (C1QTNF1), transcript variant 1, mRNA.	846	GC-T2128
PSD2	NM_032289.4	Human	Homo sapiens pleckstrin and Sec7 domain containing 2 (PSD2), mRNA.	2316	GC-T1548
CAPNS2	NM_032330.3	Human	Homo sapiens calpain small subunit 2 (CAPNS2), mRNA.	747	GC-V0838
RXFP2	NM_130806.5	Human	Homo sapiens relaxin family peptide receptor 2 (RXFP2), transcript variant 1, mRNA.	2265	GC-T3628
GINM1	NM_138785.5	Human	Homo sapiens glycoprotein integral membrane 1 (GINM1), mRNA.	993	GC-T2566
TMEM190	NM_139172.3	Human	Homo sapiens transmembrane protein 190 (TMEM190), mRNA.	534	GC-T3258
CLRN3	NM_152311.5	Human	Homo sapiens clarin 3 (CLRN3), mRNA.	681	GC-T4046
TMEM255B	NM_182614.4	Human	Homo sapiens transmembrane protein 255B (TMEM255B), transcript variant 1, mRNA.	981	GC-T2557
C1QTNF1	NM_198594.4	Human	Homo sapiens C1q and TNF related 1 (C1QTNF1), transcript variant 4, mRNA.	600	GC-Z3455
ZDHHC24	NM_207340.3	Human	Homo sapiens zinc finger DHHC-type containing 24 (ZDHHC24), transcript variant 1, mRNA.	855	GC-Y2743
GPR153	NM_207370.4	Human	Homo sapiens G protein-coupled receptor 153 (GPR153), mRNA.	1830	GC-Y5262
HCRTR2	NM_001526.5	Human	Homo sapiens hypocretin receptor 2 (HCRTR2), transcript variant 2, mRNA.	1335	GC-U0063
SELENOP	NM_001085486.3	Human	Homo sapiens selenoprotein P (SELENOP), transcript variant 2, mRNA.	1146	GC-Z5668
BECN1	NM_003766.5	Human	Homo sapiens beclin 1 (BECN1), transcript variant 1, mRNA.	1353	GC-Z7498
CTDNEP1	NM_001143775.2	Human	Homo sapiens CTD nuclear envelope phosphatase 1 (CTDNEP1), transcript variant 2, mRNA.	735	GC-Z6793
SPARCL1	NM_001128310.3	Human	Homo sapiens SPARC like 1 (SPARCL1), transcript variant 1, mRNA.	1995	GC-Z6357
AKT1	NM_001014431.2	Human	Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 3, mRNA.	1443	GC-Z5980
TFG	NM_001007565.2	Human	Homo sapiens trafficking from ER to golgi regulator (TFG), transcript variant 2, mRNA.	1203	GC-Z5959
SDCBP	NM_001007067.2	Human	Homo sapiens syndecan binding protein (SDCBP), transcript variant 2, mRNA.	897	GC-Z5957
FGFRL1	NM_001004356.3	Human	Homo sapiens fibroblast growth factor receptor like 1 (FGFRL1), transcript variant 1, mRNA.	1515	GC-Z5940
CD36	NM_001127444.2	Human	Homo sapiens CD36 molecule (CD36), transcript variant 5, mRNA.	1419	GC-I0616
SLC30A7	NM_001144884.2	Human	Homo sapiens solute carrier family 30 member 7 (SLC30A7), transcript variant 2, mRNA.	1131	GC-H4073
SLC39A14	NM_001128431.4	Human	Homo sapiens solute carrier family 39 member 14 (SLC39A14), transcript variant 1, mRNA.	1479	GC-H3674
GJB6	NM_001110219.3	Human	Homo sapiens gap junction protein beta 6 (GJB6), transcript variant 1, mRNA.	786	GC-H3552
GRB7	NM_001030002.3	Human	Homo sapiens growth factor receptor bound protein 7 (GRB7), transcript variant 2, mRNA.	1599	GC-H3387
PLEKHA1	NM_001001974.4	Human	Homo sapiens pleckstrin homology domain containing A1 (PLEKHA1), transcript variant 2, mRNA.	1215	GC-H3321
GIPC1	NM_202470.3	Human	Homo sapiens GIPC PDZ domain containing family member 1 (GIPC1), transcript variant 5, mRNA.	1002	GC-A1523
KCNJ15	NM_170737.3	Human	Homo sapiens potassium inwardly rectifying channel subfamily J member 15 (KCNJ15), transcript variant 3, mRNA.	1128	GC-A1517
PRNP	NM_000311.5	Human	Homo sapiens prion protein (PRNP), transcript variant 1, mRNA.	762	GC-I2265
GNAZ	NM_002073.4	Human	Homo sapiens G protein subunit alpha z (GNAZ), mRNA.	1068	GC-A6359
GHR	NM_000163.4.01	Human	Homo sapiens growth hormone receptor (GHR), transcript variant 1, mRNA. Codon-optimized for Homo sapiens.	1917	GC-X1012
IHH	NM_002181.3.01	Human	Homo sapiens indian hedgehog (IHH), mRNA. Codon-optimized for Homo sapiens.	1236	GC-X1015
HAVCR1	NM_012206.3	Human	Homo sapiens hepatitis A virus cellular receptor 1 (HAVCR1), transcript variant 1, mRNA.	1095	GC-A8892
A2M	NM_000014.5	Human	Homo sapiens alpha-2-macroglobulin (A2M), transcript variant 1, mRNA.	4425	GC-A3521
ACADVL	NM_000018.4	Human	Homo sapiens acyl-CoA dehydrogenase very long chain (ACADVL), transcript variant 1, mRNA; nuclear gene for mitochondrial product.	1968	GC-M0675
ACVRL1	NM_000020.3	Human	Homo sapiens activin A receptor like type 1 (ACVRL1), transcript variant 1, mRNA.	1512	GC-M0844
PSEN1	NM_000021.4	Human	Homo sapiens presenilin 1 (PSEN1), transcript variant 1, mRNA.	1404	GC-Z0049
ADA	NM_000022.3	Human	Homo sapiens adenosine deaminase (ADA), transcript variant 1, mRNA.	1092	GC-C0190
SGCA	NM_000023.4	Human	Homo sapiens sarcoglycan alpha (SGCA), transcript variant 1, mRNA.	1164	GC-G0655
ADRB3	NM_000025.3	Human	Homo sapiens adrenoceptor beta 3 (ADRB3), mRNA.	1227	GC-U1168
ABCD1	NM_000033.4	Human	Homo sapiens ATP binding cassette subfamily D member 1 (ABCD1), mRNA.	2238	GC-C0357