All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

Immuno-oncology

Introduction

Immuno-oncology is a scientific field that studies the interactions between tumors and the immune system, revealing how tumors evade the immune surveillance and elimination, as well as how they exploit the mechanisms of the immune system to promote their growth and spread. Cancer immunotherapy, developed on the theoretical foundation of immuno-oncology, represents a revolutionary approach to treatment. It activates or enhances the patient’s own immune system to recognize and destroy cancer cells, fundamentally differing from traditional cancer treatments such as surgery, radiation, and chemotherapy. Cancer immunotherapy comes in a variety of forms, including targeted antibodies, cancer vaccines, adoptive cell transfer, tumor-infecting viruses, checkpoint inhibitors, cytokines, and adjuvants.

Application

The Immuno-oncology clone set can be used in GSRA technology to perform high-throughput screening of various transmembrane or secreted proteins interacting with target proteins.The Genome-Scale Receptor Array (GSRA) is a semi-automated gene expression and detection system invented by Prof. Lieping Chen’s team, which is used to rapidly detect protein-protein interactions. This clone set fuels a number of research results. Screening of ligand proteins for LAG-3, revealing the role of this LAG-3-FGL1 pathway in tumour immunity and therapy^[1]. Demonstrating that Siglec-15 inhibits antigen-specific T-cell responses in vitro and in vivo, and can serve as a potential target for cancer immunotherapy^[2]. Identifying IGFBP7 interacts with its receptor CD93, and subsequently demonstrated that this interaction contributes to abnormal tumor vasculature^[3]. And showing CD8α is critical for the maintenance of CD8+ T cells in a physiologically quiescent state in peripheral lymphoid organs^[4].

Reference

Wang, F., et al., Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell, 2018
Wang J, Sun J, Liu L N, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature medicine, 2019
Sun Y, Chen W, Torphy R J, et al. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science Translational Medicine, 2021
Zheng, L., et al., The CD8α-PILRα interaction maintains CD8+ T cell quiescence. Science, 2022

Clone set information

Cat. no.	Species	Gene	Vector	Vector Type	Price
OC-HIO-M02	Human	6592	pReceiver-M02	Expression-ready Non-viral	Inquire
OC-HIO-M35	Human	6592	pReceiver-M35	Expression-ready Non-viral	Inquire
OC-HIO-M98	Human	6592	pReceiver-M98	Expression-ready Non-viral	Inquire
OC-HIO-Lv105	Human	6592	pReceiver-Lv105	Expression-ready Non-viral	Inquire
OC-HIO-Lv242	Human	6592	pReceiver-Lv242	Expression-ready Lentiviral	Inquire
OC-HIO-GC	Human	6592	pDONR™ Vector	Gateway shuttle	Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.

Symbol	Accession	Species	Description	ORF length(bp)	Product ID
TNFRSF9	NM_001561.6	Human	Homo sapiens TNF receptor superfamily member 9 (TNFRSF9), mRNA.	768	GC-A0225
A1BG	NM_130786.4	Human	Homo sapiens alpha-1-B glycoprotein (A1BG), mRNA.	1488	GC-T3535
A2M	NM_000014.5	Human	Homo sapiens alpha-2-macroglobulin (A2M), transcript variant 1, mRNA.	4425	GC-A3521
A2ML1	NM_144670.6	Human	Homo sapiens alpha-2-macroglobulin like 1 (A2ML1), transcript variant 1, mRNA.	4365	GC-D0701
A4GALT	NM_017436.7	Human	Homo sapiens alpha 1,4-galactosyltransferase (P blood group) (A4GALT), transcript variant 1, mRNA.	1062	GC-U0876
A4GNT	NM_016161.3	Human	Homo sapiens alpha-1,4-N-acetylglucosaminyltransferase (A4GNT), mRNA.	1023	GC-U0796
AAAS	NM_015665.6	Human	Homo sapiens aladin WD repeat nucleoporin (AAAS), transcript variant 1, mRNA.	1641	GC-V0141
AADAC	NM_001086.3	Human	Homo sapiens arylacetamide deacetylase (AADAC), mRNA.	1200	GC-A4273
ABCA1	NM_005502.4	Human	Homo sapiens ATP binding cassette subfamily A member 1 (ABCA1), mRNA.	6786	GC-A4304
ABCA4	NM_000350.2	Human	Homo sapiens ATP binding cassette subfamily A member 4 (ABCA4), mRNA.	6822	GC-Q0446
ABCA5	NM_018672.5	Human	Homo sapiens ATP binding cassette subfamily A member 5 (ABCA5), transcript variant 1, mRNA.	4929	GC-H4609
ABCA6	NM_080284.3	Human	Homo sapiens ATP binding cassette subfamily A member 6 (ABCA6), mRNA.	4854	GC-I1895
ABCA8	NM_007168.4	Human	Homo sapiens ATP binding cassette subfamily A member 8 (ABCA8), transcript variant 2, mRNA.	4746	GC-T0048
ABCB1	NM_000927.5	Human	Homo sapiens ATP binding cassette subfamily B member 1 (ABCB1), transcript variant 3, mRNA.	3843	GC-E2266
ABCB1	NM_001348945.2	Human	Homo sapiens ATP binding cassette subfamily B member 1 (ABCB1), transcript variant 1, mRNA.	4053	GC-E3923
ABCB11	NM_003742.2.01	Human	Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA. Codon-optimized for Homo sapiens.	3966	GC-X1007
ABCB11	NM_003742.4	Human	Homo sapiens ATP binding cassette subfamily B member 11 (ABCB11), mRNA.	3966	GC-H5308
ABCB4	NM_000443.4	Human	Homo sapiens ATP binding cassette subfamily B member 4 (ABCB4), transcript variant A, mRNA.	3840	GC-G0814
ABCB4	NM_018850.3	Human	Homo sapiens ATP binding cassette subfamily B member 4 (ABCB4), transcript variant C, mRNA.	3699	GC-Z4744
ABCB5	NM_178559.6	Human	Homo sapiens ATP binding cassette subfamily B member 5 (ABCB5), transcript variant 2, mRNA.	2439	GC-E2036
ABCB6	NM_005689.4	Human	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA.	2529	GC-T1895
ABCB7	NM_001271696.3	Human	Homo sapiens ATP binding cassette subfamily B member 7 (ABCB7), transcript variant 2, mRNA; nuclear gene for mitochondrial product.	2259	GC-Y5172
ABCB7	NM_004299.6	Human	Homo sapiens ATP binding cassette subfamily B member 7 (ABCB7), transcript variant 1, mRNA; nuclear gene for mitochondrial product.	2262	GC-Y2039
ABCB8	NM_007188.5	Human	Homo sapiens ATP binding cassette subfamily B member 8 (ABCB8), transcript variant 2, mRNA; nuclear gene for mitochondrial product.	2157	GC-U0894
ABCB9	NM_001243014.2	Human	Homo sapiens ATP binding cassette subfamily B member 9 (ABCB9), transcript variant 5, mRNA.	2046	GC-I0755
ABCB9	NM_019625.4	Human	Homo sapiens ATP binding cassette subfamily B member 9 (ABCB9), transcript variant 1, mRNA.	2301	GC-T0728
ABCC1	NM_004996.4	Human	Homo sapiens ATP binding cassette subfamily C member 1 (ABCC1), mRNA.	4596	GC-Z4479
ABCC10	NM_033450.3	Human	Homo sapiens ATP binding cassette subfamily C member 10 (ABCC10), transcript variant MRP7A, mRNA.	4395	GC-E2232
ABCC11	NM_033151.4	Human	Homo sapiens ATP binding cassette subfamily C member 11 (ABCC11), transcript variant 2, mRNA.	4149	GC-W1207
ABCC2	NM_000392.4	Human	Homo sapiens ATP binding cassette subfamily C member 2 (ABCC2), mRNA.	4638	GC-Q0603
ABCC2	NM_000392.5	Human	Homo sapiens ATP binding cassette subfamily C member 2 (ABCC2), mRNA.	4638	GC-A8900
ABCC4	NM_001105515.3	Human	Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 2, mRNA.	2580	GC-T9124
ABCC4	NM_005845.5	Human	Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 1, mRNA.	3978	GC-T0262
ABCC8	NM_000352.6	Human	Homo sapiens ATP binding cassette subfamily C member 8 (ABCC8), transcript variant 2, mRNA.	4746	GC-Y4894
ABCD1	NM_000033.4	Human	Homo sapiens ATP binding cassette subfamily D member 1 (ABCD1), mRNA.	2238	GC-C0357
ABCD3	NM_001122674.2	Human	Homo sapiens ATP binding cassette subfamily D member 3 (ABCD3), transcript variant 2, mRNA.	711	GC-T7842
ABCG1	NM_004915.4	Human	Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 4, mRNA.	2037	GC-Z0825
ABCG1	NM_016818.3	Human	Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 2, mRNA.	2001	GC-Z3287
ABCG1	NM_207628.1	Human	Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 6, mRNA.	1935	GC-Z8089
ABCG2	NM_004827.3	Human	Homo sapiens ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2), transcript variant 1, mRNA.	1968	GC-Q0668
ABCG4	NM_022169.5	Human	Homo sapiens ATP binding cassette subfamily G member 4 (ABCG4), transcript variant 1, mRNA.	1941	GC-Z1538
ABHD1	NM_032604.4	Human	Homo sapiens abhydrolase domain containing 1 (ABHD1), mRNA.	1218	GC-W2844
ABHD12	NM_015600.5	Human	Homo sapiens abhydrolase domain containing 12, lysophospholipase (ABHD12), transcript variant 2, mRNA.	1215	GC-T2637
ABHD13	NM_032859.3	Human	Homo sapiens abhydrolase domain containing 13 (ABHD13), mRNA.	1014	GC-T8787
ABHD17A	NM_001130111.2	Human	Homo sapiens abhydrolase domain containing 17A, depalmitoylase (ABHD17A), transcript variant 2, mRNA.	933	GC-Z6406
ABHD17A	NM_031213.4	Human	Homo sapiens abhydrolase domain containing 17A, depalmitoylase (ABHD17A), transcript variant 1, mRNA.	1086	GC-Z9629
ABHD2	NM_152924.5	Human	Homo sapiens abhydrolase domain containing 2, acylglycerol lipase (ABHD2), transcript variant 2, mRNA.	1278	GC-G0334
ABHD3	NM_138340.5	Human	Homo sapiens abhydrolase domain containing 3, phospholipase (ABHD3), transcript variant 1, mRNA.	1230	GC-H4722
ABHD6	NM_001320126.2	Human	Homo sapiens abhydrolase domain containing 6, acylglycerol lipase (ABHD6), transcript variant 1, mRNA.	1014	GC-V0321
ABI1	NM_005470.4	Human	Homo sapiens abl interactor 1 (ABI1), transcript variant 1, mRNA.	1527	GC-Z4495