Cytokines and cytokine receptors

Introduction

Cytokines (CK) are low molecular weight soluble proteins (5-20 kDa) induced in a variety of cells by immunogens, mitogens, or other stimuli, generally through binding to the corresponding cytokine receptor on the cell surface, and through signaling, causing changes in cellular gene transcription.
Cytokines have a variety of functions such as regulating intrinsic and adaptive immunity, hematopoiesis, cell growth, APSC pluripotent cells, and repair of damaged tissues. Cytokines can be classified according to their main functions: interleukins (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), transforming growth factor-β family (TGF-β family), growth factors (GF), and chemokine family.
Most cytokine receptors (CK-R) are heterodimers or multimers consisting of two or more subunits, usually including a specific ligand-binding alpha chain and a beta chain involved in signaling. In the natural state, cytokine receptors exist mainly in two forms: membrane-bound cytokine receptors (mCK-R) and soluble cytokine receptors (sCK-R) present in body fluids such as serum.
The complex biological activity of the cytokine is mediated primarily through binding to the corresponding mCK-R while sCK-R has a unique biological significance. Changes in sCK-R levels in relation to certain diseases have been increasingly emphasized by scholars, and some recombinant sCK-R genetically engineered products have been clinically validated.

Clone set information

Cat. No. Old Cat. No. Species Gene Vector Vector Type Price
OC-GF001-M02 OC-HCC-M02 Human 423 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF001-M35 OC-HCC-M35 Human 423 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF001-M98 OC-HCC-M98 Human 423 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF001-Lv105 OC-HCC-Lv105 Human 423 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF001-Lv242 OC-HCC-Lv242 Human 423 pReceiver-Lv242 Expression-ready Lentiviral Inquire
OC-GF001-GC OC-HCC-GC Human 423 pDONR™ Vector Gateway shuttle Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
CD40LG NM_000074.3 Human Homo sapiens CD40 ligand (CD40LG), mRNA. 786 GC-G0117
NDP NM_000266.4 Human Homo sapiens norrin cystine knot growth factor NDP (NDP), mRNA. 402 GC-G0575
TGFBI NM_000358.3 Human Homo sapiens transforming growth factor beta induced (TGFBI), mRNA. 2052 GC-G0262
THPO NM_000460.4 Human Homo sapiens thrombopoietin (THPO), transcript variant 1, mRNA. 1062 GC-N0065
GDNF NM_000514.4 Human Homo sapiens glial cell derived neurotrophic factor (GDNF), transcript variant 1, mRNA. 636 GC-Z0010
IL10 NM_000572.3 Human Homo sapiens interleukin 10 (IL10), transcript variant 1, mRNA. 537 GC-A0007
IL1A NM_000575.5 Human Homo sapiens interleukin 1 alpha (IL1A), transcript variant 1, mRNA. 816 GC-A0179
IL1B NM_000576.3 Human Homo sapiens interleukin 1 beta (IL1B), mRNA. 810 GC-A0180
IL1RN NM_000577.5 Human Homo sapiens interleukin 1 receptor antagonist (IL1RN), transcript variant 3, mRNA. 480 GC-T2817
SPP1 NM_000582.3 Human Homo sapiens secreted phosphoprotein 1 (SPP1), transcript variant 2, mRNA. 903 GC-D0399
CXCL8 NM_000584.4 Human Homo sapiens C-X-C motif chemokine ligand 8 (CXCL8), transcript variant 1, mRNA. 300 GC-I0329
IL15 NM_000585.5 Human Homo sapiens interleukin 15 (IL15), transcript variant 3, mRNA. 489 GC-T0091
IL2 NM_000586.4 Human Homo sapiens interleukin 2 (IL2), mRNA. 462 GC-A0413
IL3 NM_000588.4 Human Homo sapiens interleukin 3 (IL3), mRNA. 459 GC-H9499
IL4 NM_000589.4 Human Homo sapiens interleukin 4 (IL4), transcript variant 1, mRNA. 462 GC-A0173
IL9 NM_000590.2 Human Homo sapiens interleukin 9 (IL9), mRNA. 435 GC-T1772
TNF NM_000594.4 Human Homo sapiens tumor necrosis factor (TNF), mRNA. 702 GC-A0276
IL6 NM_000600.5 Human Homo sapiens interleukin 6 (IL6), transcript variant 1, mRNA. 639 GC-A0301
HGF NM_000601.6 Human Homo sapiens hepatocyte growth factor (HGF), transcript variant 1, mRNA. 2187 GC-A0820
IFNA2 NM_000605.4 Human Homo sapiens interferon alpha 2 (IFNA2), mRNA. 567 GC-A0813
CXCL12 NM_000609.7 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 2, mRNA. 282 GC-A0590
CNTF NM_000614.4 Human Homo sapiens ciliary neurotrophic factor (CNTF), mRNA. 603 GC-Y2796
IGF1 NM_000618.5 Human Homo sapiens insulin like growth factor 1 (IGF1), transcript variant 4, mRNA. 462 GC-A0153
IFNG NM_000619.3 Human Homo sapiens interferon gamma (IFNG), mRNA. 501 GC-A0177
FASLG NM_000639.3 Human Homo sapiens Fas ligand (FASLG), transcript variant 1, mRNA. 846 GC-L0009
IL11 NM_000641.4 Human Homo sapiens interleukin 11 (IL11), transcript variant 1, mRNA. 600 GC-A0158
TGFB1 NM_000660.7 Human Homo sapiens transforming growth factor beta 1 (TGFB1), mRNA. 1173 GC-Z5895
CSF2 NM_000758.4 Human Homo sapiens colony stimulating factor 2 (CSF2), mRNA. 435 GC-A4234
CSF3 NM_000759.4 Human Homo sapiens colony stimulating factor 3 (CSF3), transcript variant 1, mRNA. 624 GC-Z0547
EPO NM_000799.4 Human Homo sapiens erythropoietin (EPO), mRNA. 582 GC-A1011
IL5 NM_000879.3 Human Homo sapiens interleukin 5 (IL5), mRNA. 405 GC-A0169
IL7 NM_000880.4 Human Homo sapiens interleukin 7 (IL7), transcript variant 1, mRNA. 534 GC-A0790
IL12A NM_000882.4 Human Homo sapiens interleukin 12A (IL12A), transcript variant 1, mRNA. 762 GC-A0034
KITLG NM_000899.5 Human Homo sapiens KIT ligand (KITLG), transcript variant b, mRNA. 822 GC-A0012
CCL3L3 NM_001001437.4 Human Homo sapiens C-C motif chemokine ligand 3 like 3 (CCL3L3), mRNA. 282 GC-Z5675
GDF6 NM_001001557.4 Human Homo sapiens growth differentiation factor 6 (GDF6), mRNA. 1368 GC-Y3324
HGF NM_001010931.3 Human Homo sapiens hepatocyte growth factor (HGF), transcript variant 2, mRNA. 873 GC-Z3545
HGF NM_001010932.3 Human Homo sapiens hepatocyte growth factor (HGF), transcript variant 3, mRNA. 2172 GC-Z4094
HGF NM_001010933.3 Human Homo sapiens hepatocyte growth factor (HGF), transcript variant 4, mRNA. 858 GC-Z3546
HGF NM_001010934.3 Human Homo sapiens hepatocyte growth factor (HGF), transcript variant 5, mRNA. 633 GC-Z3547
IL32 NM_001012718.4 Human Homo sapiens interleukin 32 (IL32), transcript variant 8, mRNA. 567 GC-M0733
IL31 NM_001014336.2 Human Homo sapiens interleukin 31 (IL31), mRNA. 495 GC-Y3720
VEGFA NM_001025366.3 Human Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 1, mRNA. 1239 GC-Z2831
VEGFA NM_001025368.3 Human Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 4, mRNA. 1116 GC-Z5634
VEGFA NM_001025369.3 Human Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 5, mRNA. 1065 GC-H3076
EFEMP1 NM_001039349.3 Human Homo sapiens EGF containing fibulin extracellular matrix protein 1 (EFEMP1), transcript variant 3, mRNA. 1482 GC-T1858
FAM3C NM_001040020.2 Human Homo sapiens FAM3 metabolism regulating signaling molecule C (FAM3C), transcript variant 2, mRNA. 684 GC-V1620
SPP1 NM_001040058.2 Human Homo sapiens secreted phosphoprotein 1 (SPP1), transcript variant 1, mRNA. 945 GC-I0343
TGFA NM_001099691.3 Human Homo sapiens transforming growth factor alpha (TGFA), transcript variant 2, mRNA. 480 GC-A0352
NTF3 NM_001102654.2 Human Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA. 813 GC-Z5643