For focused group profiling of exosome-related miRNA expression
miProfile™ exosome miRNA qPCR arrays profile the expression of exosome-related miRNAs, which are carefully chosen for their close exosome correlation based on a thorough literature search of peer-reviewed publications. Arrays are available for expression profiling of specific types of exosome-related miRNAs or overall exosome-related miRNAs.
Exosomes have important roles in the spread of protein, mRNA, miRNA and DNA and they are the contributing factors in the development of several diseases. Exosomes essentially deliver many of their functions as an intercellular shuttle with a cargo of proteins and RNAs for target cell regulation. The miProfile™ exosome arrays allow researchers to profile the differential expression of miRNAs in exosomes from different samples (urine, blood, or milk) and various cancers to gain understanding of the role of miRNA in the intercommunication occurring between different cells. Exosomal miRNAs in the tumor microenvironment may impact tumor proliferation, vascularization, metastasis and other biological characteristics. Exosomal miRNAs are likely to be applied as promising non-invasive biomarkers and potential targetable factors in cancer diagnosis and treatment.
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Advantages
- Close exosome correlation – miRNAs are carefully chosen for their close exosome correlation based on a thorough literature search of peer-reviewed publications
- Sensitive – Detect miRNA from as little as 10 pg of small RNA or 20 pg of total RNA
- Specific – Be able to distinguish miRNAs with single nucleotide mismatches. Each primer set has been experimentally validated for specific amplification
- Broad linearity– Allow miRNAs at variable expression levels to be detected simultaneously
- Reproducible – High reproducibility (R2>0.99) for inter-array and intra-array replicates
- Validated miRNA primers – Each miRNA primer is designed using a proprietary algorithm and experimentally validated
