You are here: Home > Products >

Autoantigens General Survey Microarray

Autoimmune diseases occur when the immune system, which normally does not attack a person's own components, produces self-reacting T-cells or circulating antibodies that recognize host proteins, also known as autoantigens. Over 100 autoimmune diseases have been described, creating a critical need for tools that can detect large numbers of autoantibodies with high sensitivity.

GeneCopoeia’s OmicsArray™ Autoantigens General Survey Antigen Microarray is a powerful tool for detection of autoantibodies associated with many diseases, including rheumatoid arthritis, muscular dystrophy, systemic lupus erythematosus, and type 1 diabetes. The array carries 80 superior-quality purified proteins, spotted onto nitrocellulose filters, which are adhered to glass slides, that are known antigens in various autoimmune diseases. Antigens known to be associated with specific diseases are chosen based on a thorough review of peer-reviewed publications.

In addition to this predesigned array, arrays containing customized sets of proteins are available, as well as array profiling services and data analysis.

GeneCopoeia’s OmicsArray™ Autoantigens General Survey Antigen Microarray is part of the GeneCopoeia OmicsArray™ Antigen Microarray family.

Advantages
  • Multiplexing capable.  OmicsArray™ antigen microarrays can assay up to 120 proteins at a time, compared with 1 protein at a time for ELISA.
  • High throughput.  Each slide can process up to 15 samples in parallel.
  • High sensitivity. Each array can detect as little as 1 pg/ml of antibody, which is 100-fold more sensitive than ELISA.
  • Small sample volume. As little as 1 ul of serum is needed for detection.
  • Fast. From sample-to-data in as little as 2 weeks.

Predesigned array

Predesigned antigen microarray

GeneCopoeia’s OmicsArray™ Autoantigens General Survey Antigen Microarray is a predesigned antigen microarray. A partial list of the antigens spotted on this array are indicated in Table 1, under "Product Details". Custom antigen microarrays are also available. To inquire about a custom antigen microarray, please contact inquiry@genecopoeia.com.

Product Details

 

Antigen Associated disease
TIF1 gamma Myositis
RNP/Sm Systemic Lupus Erythematosus
GBM Goodpasture's Syndrome
Ro/SS-A (52 kDa) Sjogrens Syndrome
Tissue transglutaminase (TTG) Celiac Disease
Intrinsic factor (IF) Pernicious Anemia
BCOADC-E2 Primary Biliary Cirrhosis
GP2 Crohn's Disease
LKM-1 Autoimmune Hepatitis
Insulinoma-associated (IA-2) Diabetes Mellitus
Collagen VI Muscular dystrophy
Vimentin Rheumatoid Arthritis
Aldolase A human (muscle) Diabetic retinopathy
Complement C1q Lupus nephritis
MPO ANCA Associated Diseases
Vitronectin Primary systemic vasculitis
Fibrinogen Chronic liver disease
ß2-Glycoprotein 1 (Apo H) Antiphospholipid Syndrome/ Thromboembolic Syndrome
U1-snRNP 68/70 kDa Mixed Connective Tissue Disease
B2 Glycoprotein I (B2GP1) Antiphospholipid Syndrome/ Thromboembolic Syndrome
PM/Scl100 Systemic Sclerosis/CREST Syndrome

 

Table 1. Partial list of antigens on GeneCopoeia's Autoantigen General Survey Antigen Microarray.