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COVID-19 Coronavirus Antigen Microarrays

SARS-CoV-2 is a betacoronavirus that is the cause of the COVID-19 global pandemic that began in 2019. SARS-CoV-2 infection of humans typically stimulates a strong humoral immunity response, leading to the production of both neutralizing and binding antibodies.

GeneCopoeia provides two antigen microarrays for detection of antibodies against SARS-CoV-2 and other pathogens. The OmicsArray™ COVID-19 Coronavirus Antigen Microarrays are protein microarrays enabling powerful detection of antibodies associated with virus infections, including SARS-CoV-2, SARS-CoV-1 (the cause of the 2002-2004 SARS outbreak), influenza viruses, and others. The standard array carries 16 proteins, and the expanded array carries 41 proteins. Each protein is spotted onto nitrocellulose filters, which are adhered to glass slides. Viral proteins are chosen based on a thorough review of peer-reviewed publications.

In addition to these predesigned arrays, arrays containing customized sets of proteins are available, as well as array profiling services and data analysis.

GeneCopoeia’s OmicsArray™ SARS-CoV-2 Coronavirus Antigen Microarrays are part of the GeneCopoeia OmicsArray™ Antigen Microarray family.

Advantages
  • Multiplexing capable.  OmicsArray™ antigen microarrays can assay up to 120 antigens at a time, compared with 1 protein at a time for ELISA.
  • High throughput.  Each slide can process up to 15 samples in parallel.
  • High sensitivity. Each array can detect as little as 1 pg/ml of antibody, which is 100-fold more sensitive than ELISA.
  • Small sample volume. As little as 1 ul of serum is needed for detection.
  • Fast. From sample-to-data in as little as 2 weeks.

Predesigned array

Predesigned antigen microarrays

GeneCopoeia’s OmicsArray™ COVID-19 Coronavirus Antigen Microarrays are predesigned protein microarrays. A list of the antigens spotted on each array is displayed in the drop-down menus below.

Custom protein microarrays are also available. To inquire about a custom protein microarray, please contact inquiry@genecopoeia.com.

COVID-19 Coronavirus Antigen Microarray Panel 1 (16 antigens)

Antigen Associated disease
SARS-CoV-2 Spike protein S1 COVID-19
SARS-CoV-2 Spike protein S1 RBD COVID-19
SARS-CoV-2 Spike S2 COVID-19
SARS-CoV-2 Spike S2 ECD COVID-19
SARS-CoV-2 Spike S1 + S2 COVID-19
SARS-CoV-2 Nucleocapsid protein (NCP) COVID-19
SARS-CoV-1 Spike protein SARS (2002-2004)
SARS-CoV-1 NCP SARS (2002-2004)
MERS-CoV Spike Protein MERS (2012-present)
HCoV-229E Spike protein Common cold (seasonal)
HCoV-HKU1 Spike protein Common cold (seasonal)
HCoV-NL63 Spike protein Common cold (seasonal)
HCoV-OC43 Spike protein Common cold (seasonal)
Influenza A antigen Seasonal influenza
Influenza B antigen Seasonal influenza
RSV Glycoprotein G Common cold-like respiratory disease

 

Table 1. List of antigens on GeneCopoeia's COVID-19 Coronavirus Antigen Microarray Panel 1.

COVID-19 Coronavirus Antigen Microarray Panel 2 (41 antigens)

Antigen Associated disease
SARS-CoV-2 3CL Mpro COVID-19
SARS-CoV-2 3CL COVID-19
SARS-CoV-2 Envelope protein COVID-19
SARS-CoV-2 ME COVID-19
SARS-CoV-2 N COVID-19
SARS-CoV-2 NCP COVID-19
SARS-CoV-2 NCP COVID-19
SARS-CoV-2 Plpro COVID-19
SARS-CoV-2 S1/RBD COVID-19
SARS-CoV-2 RBD COVID-19
SARS-CoV-2 S1 COVID-19
SARS-CoV-2 S1+S2 COVID-19
SARS-CoV-2 S2 ECD COVID-19
SARS-CoV-1 NP SARS (2002-2004)
SARS-CoV-1 Plpro SARS (2002-2004)
SARS-CoV-1 S1 SARS (2002-2004)
SARS-CoV-1 S1/RBD SARS (2002-2004)
MERS-CoV NP MERS (2012-present)
MERS-CoV S MERS (2012-present)
HCoV-229E Spike protein Common cold (seasonal)
HCoV-HKU1 S1 Common cold (seasonal)
HCoV-HKU1 Spike protein Common cold (seasonal)
HCoV-NL63 Spike protein Common cold (seasonal)
HCoV-OC43 Spike Common cold (seasonal)
CMV Native protein Cytomegalovirus
CMV Pp65(UL83) Cytomegalovirus
Influenza A Seasonal influenza
IAV H1N1 Seasonal influenza
IAV H3N2 Seasonal influenza
Influenza B Seasonal influenza
IBV Nucleoprotein Seasonal influenza
Mycoplasma Pneumoniae Mycoplasma Pneumoniae
Norovirus vp1 Norovirus
Respiratory Syncytial Virus Antigen (RSV) Common cold-like respiratory disease
Corynebacterium diphtheria Diphtheria
poliovirus type 1 Polio
poliovirus type 2 Polio
poliovirus type 3 Polio
SCL-70 Autoantigen
dsDNA Autoantigen
Jo-1 Autoantigen

 

Table 2. List of antigens on GeneCopoeia's COVID-19 Coronavirus Antigen Microarray Panel 2.