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COVID-19 Coronavirus Research Tools

GeneCopoeia is your one-stop shopping solution for COVID-19 research tools.

For both SARS-CoV-2, the coronavirus that causes the COVID-19 pandemic respiratory illness, as well as host factors like ACE2 and TMPRSS2, we provide:

  • Plasmid clones for ORF cDNA, gene promoters, 3' UTR miRNA targets, sgRNA, and shRNA
  • Lentivirus and AAV, particles, ready-to-use, and lentiviral packaging kits
  • CRISPR solutions
  • RT-qPCR kits and primers
  • And more!

3 NEW products coming soon!

• SARS-CoV-2 Spike protein-pseudotyped ready-to-use lentivirus

• SARS-CoV-2 Spike protein-pseudotyped lentivirus packaging kits

• Next-generation SARS-CoV-2 diagnostic testing kits (RT-qPCR based)

 

We also have plasmid clones for the related virus SARS-CoV, which caused the 2002-2004 SARS pandemic.

 

For more information or to request a quote, please contact inquiry@genecopoeia.com.

 

Plasmids
GeneCopoeia is the industry leader in expression-ready ORF cDNA clones, and we also carry reporter plasmid clones carrying gene promoters and 3' UTR microRNA (miRNA) binding site targets. We can construct ORF plasmid clones in any of our more than 250 ready-to-go vector types expressing both SARS-CoV-2 viral proteins as well as host proteins, which you can select using the drop-down menus below.

COVID-19 ORF cDNA plasmid clones-viral proteins

Order ORF cDNA clones expressing SARS-CoV-2 viral proteins

To order ORF cDNA clones expressing SARS-CoV-2 viral proteins in one of out more than 250 non-viral and lentiviral vector types, select the product ID from the table below and contact inquiry@genecopoeia.com.

Product ID Protein accession Symbol Alias Description
CoV201 (please inquire) YP_009724389.1 orf1ab GU280_gp01 orf1ab polyprotein [Severe acute respiratory syndrome coronavirus 2}, full-length gene
CoV202 YP_009725297.1 orf1ab GU280_gp01 leader protein [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV203 YP_009725298.1 orf1ab GU280_gp01 nsp2n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV204 YP_009725299.1 orf1ab GU280_gp01 nsp3n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV205 YP_009725300.1 orf1ab GU280_gp01 nsp4n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV206 YP_009725301.1 orf1ab GU280_gp01 3C-like proteinase [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV207 YP_009725302.1 orf1ab GU280_gp01 nsp6n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV208 YP_009725303.1 orf1ab GU280_gp01 nsp7n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV209 YP_009725304.1 orf1ab GU280_gp01 nsp8n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV210 YP_009725305.1 orf1ab GU280_gp01 nsp9n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV211 YP_009725306.1 orf1ab GU280_gp01 nsp10n [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV212 YP_009725307.1 orf1ab GU280_gp01 RNA-dependent RNA polymerase [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV213 YP_009725308.1 orf1ab GU280_gp01 helicase [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV214 YP_009725309.1 orf1ab GU280_gp01 3'-to-5' exonuclease [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV215 YP_009725310.1 orf1ab GU280_gp01 endoRNAse [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV216 YP_009725311.1 orf1ab GU280_gp01 2'-O-ribose methyltransferase [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV217 (please inquire) YP_009725295.1 orf1a GU280_gp01 orf1a polyprotein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV218 YP_009725312.1 orf1a GU280_gp01 produced by pp1a only [Severe acute respiratory syndrome coronavirus 2], mature peptide*
CoV219 YP_009724390.1 S GU280_gp02 surface glycoprotein;structural protein; spike protein [Severe acute respiratory syndrome coronavirus 2], full-length gene (codon optimized)
CoV220 YP_009724390.1 S1 GU280_gp02 surface glycoprotein subunit 1 [Severe acute respiratory syndrome coronavirus 2], mature peptide (codon optimized)
CoV221 YP_009724390.1 S2 GU280_gp02 surface glycoprotein subunit 2 [Severe acute respiratory syndrome coronavirus 2], mature peptide* (codon optimized)
CoV222 YP_009724390.1 RBD GU280_gp02 Receptor binding domain [Severe acute respiratory syndrome coronavirus 2], mature peptide* (codon optimized)
CoV223 YP_009724391.1 ORF3a GU280_gp03 ORF3a protein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV224 YP_009724392.1 E GU280_gp04 envelope protein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV225 YP_009724393.1 M GU280_gp05 membrane glycoprotein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV226 YP_009724394.1 ORF6 GU280_gp06 ORF6 protein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV227 YP_009724395.1 ORF7a GU280_gp07 ORF7a protein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV228 YP_009725296.1 ORF7b

GU280_gp08

ORF7b [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV229 YP_009724396.1 ORF8 GU280_gp09 ORF8 protein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV230 YP_009724397.2 N GU280_gp10 nucleocapsid phosphoprotein [Severe acute respiratory syndrome coronavirus 2], full-length gene
CoV231 YP_009725255.1 ORF10 GU280_gp11 ORF10 protein [Severe acute respiratory syndrome coronavirus 2], full-length gene

 

*Note: Mature peptides are produced as a result of proteolytic processing of larger precursor proteins. To enable expression of these proteins in cells, an ATG has been added to the 5' end of the ORF sequence.

 

For more information or to request a quote, please contact inquiry@genecopoeia.com.

 

COVID-19 ORF cDNA plasmid clones-ACE2

You can purchase ORF cDNA clones expressing human host proteins that SARS-CoV-2 interacts with, including ACE2, which encodes the receptor for SARS-CoV-2 on respiratory epithelial cells, in more than 250 non-viral and lentiviral vector types. Either view all standard clones using the buttons below, or choose human clones in several popular vector types in the table. If you don't see what you need here, please contact inquiry@genecopoeia.com.

 

View all ACE2 ORF cDNA clones for human, mouse, and rat – Up to 20% OFF*

 

 

Order human ACE2 ORF cDNA clones in popular vector types

 

 

Clones in yellow shading are available for next-day shipping in bacterial stock format.**

 

Buy Catalog# Vector Type Promoter Tag / Reporter / Other Features Mammalian Selection Markers Vector Name List Price Discount price
ORF cDNA plasmid clones expressing human ACE2  

EX-U1285-M02-B

(Bacterial stock)

Mammalian CMV Untagged Neomycin pReceiver-M02 $779 $386

EX-U1285-M02-10

(10 ug purified plasmid)

Mammalian CMV Untagged Neomycin pReceiver-M02 $829 $431

EX-U1285-M98-B

(Bacterial stock)

Mammalian CMV C-eGFP(monomeric) Neomycin pReceiver-M98 $779 $386

EX-U1285-M98-10

(10 ug purified plasmid)

Mammalian CMV C-eGFP(monomeric) Neomycin pReceiver-M98 $829 $431

EX-U1285-M35

(10 ug purified plasmid)

Mammalian CMV C-Flag Neomycin pReceiver-M35 $779 $623

EX-U1285-Lv105-B

(Bacterial stock)

Lentiviral CMV Untagged Puromycin pReceiver-Lv105 $829 $431

EX-U1285-Lv105-10

(10 ug purified plasmid)

Lentiviral CMV Untagged Puromycin pReceiver-Lv105 $879 $476

EX-U1285-Lv242-B

(Bacterial stock)

Lentiviral CMV C-Avi-FLAG Puromycin pReceiver-Lv242 $879 $431

EX-U1285-Lv242-10

(10 ug purified plasmid)

Lentiviral CMV C-Avi-FLAG Puromycin pReceiver-Lv242 $929 $476

GC-U1285-B

(Bacterial stock)

Gateway PLUS shuttle Untagged pShuttle™ $779 $431

GC-U1285-10

(10 ug purified plasmid)

Gateway PLUS shuttle Untagged pShuttle™ $829 $476

 

 

 

For more information or to request a quote, please contact inquiry@genecopoeia.com.

* Promotion valid for US & Canada only. International customers, please contact your local distributor for pricing information. Discount on ORF is not valid on $69/$99 clones, secondary or control clones. Also not valid on custom service or gene synthesis clones. Discount is only valid on clones that express ACE2 & TMPRSS2. Not valid on previous purchases. Promotion ends June 30, 2020.

** Next-day shipping is available for NextDay ORF clones in bacterial stock format. Lead times for NextDay ORF clones in purified plasmid is ~3-5 days. Orders for NextDay ORF clones must be received by 12PM EST Mon-Thurs in order to be processed and shipped the next day.

COVID-19 ORF cDNA plasmid clones-TMPRSS2

You can purchase ORF cDNA clones expressing human host proteins that SARS-CoV-2 interacts with, including TMPRSS2, a serine protease required for S protein priming, in more than 250 non-viral and lentiviral vector types. Either view all standard clones using the buttons below, or choose human clones in several popular vector types in the table. If you don't see what you need here, please contact inquiry@genecopoeia.com.

View all TMPRSS2 ORF cDNA clones for human, mouse, and rat – Up to 20% OFF*

 

 

Order human TMPRSS2 ORF cDNA clones in popular vector types

 

 

Clones in yellow shading are available for next-day shipping in bacterial stock format.**

 

Buy Catalog# Vector Type Promoter Tag / Reporter / Other Features Mammalian Selection Markers Vector Name List Price Discount price
ORF cDNA plasmid clones expressing human TMPRSS2  

EX-Z7591-M02-B

(Bacterial stock)

Mammalian CMV Untagged Neomycin pReceiver-M02 $399 $269

EX-Z7591-M02-10

(10 ug purified plasmid)

Mammalian CMV Untagged Neomycin pReceiver-M02 $449 $314

EX-Z7591-M98-B

(Bacterial stock)

Mammalian CMV C-eGFP(monomeric) Neomycin pReceiver-M98 $399 $269

EX-Z7591-M98-10

(10 ug purified plasmid)

Mammalian CMV C-eGFP(monomeric) Neomycin pReceiver-M98 $449 $314

EX-Z7591-M35

(10 ug purified plasmid)

Mammalian CMV C-Flag Neomycin pReceiver-M35 $399 $319

EX-Z7591-Lv105-B

(Bacterial stock)

Lentiviral CMV Untagged Puromycin pReceiver-Lv105 $449 $314

EX-Z7591-Lv105-10

(10 ug purified plasmid)

Lentiviral CMV Untagged Puromycin pReceiver-Lv105 $499 $359

EX-Z7591-Lv242-B

(Bacterial stock)

Lentiviral CMV C-Avi-FLAG Puromycin pReceiver-Lv242 $499 $314

EX-Z7591-Lv242-10

(10 ug purified plasmid)

Lentiviral CMV C-Avi-FLAG Puromycin pReceiver-Lv242 $549 $359

GC-Z7591-B

(Bacterial stock)

Gateway PLUS shuttle Untagged pShuttle™ $399 $314

GC-Z7591-10

(10 ug purified plasmid)

Gateway PLUS shuttle Untagged pShuttle™ $449 $359

 

 

 

For more information or to request a quote, please contact inquiry@genecopoeia.com.

* Promotion valid for US & Canada only. International customers, please contact your local distributor for pricing information. Discount on ORF is not valid on $69/$99 clones, secondary or control clones. Also not valid on custom service or gene synthesis clones. Discount is only valid on clones that express ACE2 & TMPRSS2. Not valid on previous purchases. Promotion ends June 30, 2020.

** Next-day shipping is available for NextDay ORF clones in bacterial stock format. Lead times for NextDay ORF clones in purified plasmid is ~3-5 days. Orders for NextDay ORF clones must be received by 12PM EST Mon-Thurs in order to be processed and shipped the next day.

COVID-19 ORF cDNA plasmid clones-Cyclophilin A

The cyclophilins are a family of proline isomerases that function to aid in protein folding. Cyclophilins bind to the immunosuppressive drug cyclosporin A (CsA) and help mediate CsA's pharmacological function. While there is no published evidence yet that cyclophilins are involved in the pathogenesis of SARS-CoV-2, several groups have shown that CsA can inhibit several viruses, including the virus that caused the 2002-2004 SARS pandemic, SARS-CoV, in a cyclophilin A (CypA)-dependent fashion (reviewed in Tanaka, Y., et al., 2013. Viruses 5, 1,250). Further, CypA interacts with SARS-CoV Non-structural protein 1 (Nsp1) as demonstrated in a yeast 2-hybrid screen (Pfefferle, E., et al.. 2011; PLOS Pathogens doi:  doi:10.1371/journal.ppat.1002331). SARS-CoV is highly similar to SARS-CoV-2, and, in fact, both viruses use ACE2 as their cellular receptor. Therefore, it is reasonable to include CypA in investigations of a potential role for CypA in SARS-CoV-2 pathogenesis.

GeneCopoeia provides non-viral and lentiviral ORF cDNA clones in 250+ vector types for CYPA in human, mouse, and rat.

 

View all human cyclophilin A ORF cDNA clones

Humans have two known isoforms of cyclophilin A (PPIA). You can order human cyclophilin ORF clones in more than 250 non-viral and lentiviral vector types by clicking on the Product ID for each isoform in the table below

 

Product ID Accession Symbol Alias Description
F0323 NM_021130.4 PPIA CYPA, CYPH, HEL-S-69p Homo sapiens peptidylprolyl isomerase A (PPIA), transcript variant 1, mRNA.
T2782 NM_001300981.1 PPIA CYPA, CYPH, HEL-S-69p Homo sapiens peptidylprolyl isomerase A (PPIA), transcript variant 2, mRNA.

 

View all mouse M. musculus cyclophilin A ORF cDNA clones

Mouse M. musculus has only one known isoform of cyclophilin A (PPIA). You can order mouse cyclophilin A ORF clones in more than 250 non-viral and lentiviral vector types by clicking on the Product ID for each isoform in the table below.

 

Product ID Accession Symbol Alias Description
Mm17577 NM_008907.1 Ppia 2700098C05, Cphn, CyP-18, CypA Mus musculus peptidylprolyl isomerase A (Ppia), mRNA.

 

View all rat R. norvegicus cyclophilin A ORF cDNA clones

Rat R. norvegicus has only one known isoform of cyclophilin A (PPIA). You can order rat cyclophilin A ORF clones in more than 250 non-viral and lentiviral vector types by clicking on the Product ID for each isoform in the table below.

 

Product ID Accession Symbol Alias Description
Rn24256 NM_017101.1 Ppia CYCA, CyP-A Rattus norvegicus peptidylprolyl isomerase A (Ppia), mRNA.

 

For more information or to request a quote, please contact inquiry@genecopoeia.com.

 

COVID-19 ORF cDNA plasmid clones-FKBP1A

FK506 binding proteins (FKBP) are, like cyclophilins, proline isomerases that bind to another immunosuppressive drug, FK506 and mediate its pharmacology. While there is no published evidence yet that FKBPs are involved in the pathogenesis of SARS-CoV-2, several groups have demonstrated that FKBP1A is important for assembly of the virus that caused the 2002-2004 SARS pandemic, SARS-CoV (Pfefferle, S., et al., 2011; PLOS Pathogens doi: 10.1371/journal.ppat.1002331). SARS-CoV is highly similar to SARS-CoV-2, and, in fact, both viruses use ACE2 as their cellular receptor. Therefore, it is reasonable to include FKBP1A in investigations of a potential role for FKBP1A in SARS-CoV-2 pathogenesis.

GeneCopoeia provides non-viral and lentiviral ORF cDNA clones in 250+ vector types for FKBP1A in human, mouse, and rat.

 

View all human FKBP1A ORF cDNA clones

Humans have two known isoforms of FKBP1A. You can order human FKBP1A ORF clones in more than 250 non-viral and lentiviral vector types by clicking on the Product ID for each isoform in the table below

 

Product ID Accession Symbol Alias Description
R0062 NM_000801.4 FKBP1A FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE Homo sapiens FK506 binding protein 1A (FKBP1A), transcript variant 1, mRNA.
Z8544 NM_001199786.1 FKBP1A FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE Homo sapiens FK506 binding protein 1A (FKBP1A), transcript variant 3, mRNA.

 

View all mouse M. musculus FKBP1A ORF cDNA clones

Mouse M. musculus has four known isoforms of FKBP1A. You can order mouse FKBP1A ORF clones in more than 250 non-viral and lentiviral vector types by clicking on the Product ID for each isoform in the table below.

 

Product ID Accession Symbol Alias Description
Mm02519 NM_008019.2 Fkbp1a 12kDa, FKBP12, FKBP12-T1, FKBP12-T2, Fkbp, Fkbp1, mFKBP1, mFKBP12 Mus musculus FK506 binding protein 1a (Fkbp1a), mRNA.
Mm38146 NM_001302078.1 Fkbp1a FKBP12, Fkbp, Fkbp1 Mus musculus FK506 binding protein 1a (Fkbp1a), transcript variant 4, mRNA.
Mm38147 NM_001302079.1 Fkbp1a FKBP12, Fkbp, Fkbp1 Mus musculus FK506 binding protein 1a (Fkbp1a), transcript variant 5, mRNA.
Mm38985 NM_001355078.1 Fkbp1a FKBP12, Fkbp, Fkbp1 Mus musculus FK506 binding protein 1a (Fkbp1a), transcript variant 8, mRNA.

 

View all rat R. norvegicus FKBP1A ORF cDNA clones

Rat R. norvegicus has only one known isoform of FKBP1A. You can order rat FKBP1A ORF clones in more than 250 non-viral and lentiviral vector types by clicking on the Product ID for each isoform in the table below.

 

Product ID Accession Symbol Alias Description
Rn24112 NM_013102.3 Fkbp1a FKBP12, Fkbp2 Rattus norvegicus FKBP prolyl isomerase 1A (Fkbp1a), mRNA.

 

For more information or to request a quote, please contact inquiry@genecopoeia.com.

 

COVID-19 human host proteins ORF clone library

An ORF cDNA clone library is available that express 332 human host proteins reported to physically interact with SARS-CoV-2 proteins, as reported in a paper published in Nature from Gordon, D.E., et al. (2020): SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. Nature doi: 10.1038/s41586-020-2286-9. Customers can choose individual clones from this group, or purchase a whole clone library with ORFs cloned into many of our expression vectors.

 

For more information or to request a quote, please contact inquiry@genecopoeia.com.