VividFISH™ Disease Gene FISH Probes

The VividFISH™ ALK break apart probe set detects aberrant translocations of parts of the ALK gene on chromosome 2p23 (NCBI GeneID:238) with the echinoderm microtubule-associated protein-like 4 gene (EML4) on chromosome 2p21 (NCBI GeneID: 27436). This results in the generation of EML4-ALK fusion proteins that are associated with non-small cell lung carcinoma. The VividFISH™ ALK break apart probe set provides a valuable tool for diagnosis of non-small cell lung carcinoma in human lung tissue samples.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

The VividFISH™ CEP17/HER2 probe set detects aberrant amplification of the HER2 gene on chromosome 17 (NCBI GeneID:2064). Amplification  of HER2 is associated with poor survival from breast cancer. The VividFISH™ CEP17/HER2 probe set, which is a combination of one probe detecting the HER2 gene and a second control probe detecting the centromere of chromosome 17, provides a valuable tool for determining the prognosis of breast cancer and guiding subsequent treatment regimens.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

The VividFISH™ CEP07/c-MET probe set detects aberrant rearrangement of the c-MET gene on chromosome 7 (NCBI GeneID:4233). Activation of c-MET, a well-characterized proto-oncogene, is associated with poor survival in  many cancer types, including those of the liver, kidney, stomach, breast, colon, and brain. The VividFISH™ CEP07/c-MET probe set, which is a combination of one probe detecting the c-MET gene and a second control probe detecting the centromere of chromosome 7, provides a valuable tool for determining the prognosis of a variety of cancers and guiding subsequent treatment regimens.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

The VividFISH™ CEP07/EGFR probe set detects aberrant amplification of the EGFR gene on chromosome 7 (NCBI GeneID:1956). Activation of EGFR, a well-characterized proto-oncogene, is associated with many cancer types, including those of the lung and breast. The VividFISH™ CEP07/EGFR probe set, which is a combination of one probe detecting the EGFR gene and a second control probe detecting the centromere of chromosome 7, provides a valuable tool for diagnosis of cancers in a variety of tissues.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

The VividFISH™ CEP10/PTEN probe set detects aberrant loss of the phosphatase and tensin homolog (PTEN) gene on chromosome 10 (NCBI GeneID:5728). Loss of PTEN, a tumor suppressor, is associated with many cancer types, including those of the brain and breast. The VividFISH™ CEP10/PTEN probe set, which is a combination of one probe detecting the PTEN gene and a second control probe detecting the centromere of chromosome 10, provides a valuable tool for diagnosis of cancers in a variety of tissues.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.

Click on the product description to view images of fluorescent signals resulting from hybridization of the selected VividFISH™ probe with mammalian chromosomes.