Coronavirus Infection-associated Autoimmune Antigen Array, 120-Plex

Product Information

COVID-19 is a global pandemic caused by SARS-CoV-2, a new coronavirus strain sharing similar structures with other strains in the coronavirus family including SARS, MERS, NL63, 229E, OC43 and HKU1. SARS-CoV-2 is a 30Kb  RNA virus encoding 29 structural and non-structure proteins with different functions. SARS-CoV-2 infection initiates production of antibodies against different antigenic epitopes, but only antibodies against the receptor binding domain (RBD) of the Spike protein (S) are protective against viral infection. It is important to identify antibodies against different proteins and their cross-reactivity with antigens from other coronavirus strains. On the other hand, the severity of COVID-19 has been found to be correlated with the level of autoantibodies against self-proteins, for example, the COVID-19 patients with high level of anti-IFNa autoantibody tend to have severe clinical symptoms. Therefore, comprehensive measurement of antibodies against a broad range of self-antigens and viral antigens is critical in COVID-19 research. GeneCopoeia has developed a new comprehensive antigen protein array that contains 120 antigens, including 21 SARS-CoV-2 and other viral antigens, 42 human cytokines and chemokines, and 57 human self-antigens. This panel can be used for quantitative measurement of various antibody subtypes (e.g. IgG, IgM, IgA) against a broad range of antigens in COVID-19 patients and for evaluation of immune responses to viral infection and vaccination.

In addition to this premade array, arrays containing customized sets of antigens are available, as well as array profiling services and data analysis. To order premade or custom arrays, please contact us.

GeneCopoeia’s OmicsArray™ Coronavirus infection-associated Autoimmune Antigen Array is part of the GeneCopoeia OmicsArray™ Antigen Microarray family.

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Advantages of OmicsArray™ Antigen Microarrays
  • Largest collection of pre-made whole-protein antigen microarrays on the market.
  • Largest number of whole-protein antigens specifically focused on autoimmune diseae research.
  • Best combination of number of antigens per array (up to 120) with number of samples that can be processed per slide (up to 15).

OmicsArray™ premade antigen microarrays

For pricing, please inquire.

Cat. No. Description Application Antigen list
PA012 Coronavirus infection-associated Autoimmune Antigen Array Profiling antibodies associated with coronavirus infection and vaccination induced autoimmunity Download
 User Manual
This array is ideally suited for the following applications for use in clinical and basic research studies:
  • Detection of virus-specific antibodies against different antigens of SARS-CoV-2, other coronavirus strains, influenza virus, and respiratory syncitial virus (RSV).
  • Detection of autoantibodies against a broad range of human cytokines and chemokines, which is valuable for evaluating the relationship between anti-cytokine antibodies and COVID-19 clinical phenotypes.
  • Evaluation of how COVID-19 infection will enhance the body’s autoimmune reaction to various autoantigens and/or the interaction between autoantibodies and COVID-19 antibodies.
  • Monitoring the body’s immune reactivity to COVID-19 vaccination, by ensuring the antibody reactivities induced by COVID-19 vaccination and detecting the protective antibodies against RBD of spike antigens.

Figure 1. Arrangement of GeneCopoeia’s Coronavirus-associated Autoimmunity Microarray. Each slide contains 16 arrays. Each array can detect 120 antigen-specific antibodies. The array is highly sensitive for a broad range of sample types including blood (5ul serum or plasma), saliva, sputum, spinal fluid, nasal swabs, tears, etc., and simultaneously detects multiple antibody types (e.g. IgG, IgM, IgA) or subclasses. Array contents: 57 autoantigens, 42 cytokines, 21 virus antigens, and 8 internal controls


  1. Bastard et al., Autoantibodies against type I IFNs in patients with life-threatening COVID-19 370, 423 (2020)
  2. Choy KW. SARS-CoV-2 serological cross-reactivity with autoantibodies. Lancet Rheumatol. 2021 Jan;3(1):e15. doi: 10.1016/S2665-9913(20)30358-1
  3. de Assis RR, et al. Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray. Nat Commun. 2021 Jan 4;12(1):6. doi: 10.1038/s41467-020-20095-2
  4. Hou X, et al. Serum Protein Profiling Reveals a Landscape of Inflammation and Immune Signaling in Early-stage COVID-19 Infection. Mol Cell Proteomics. 2020 Nov;19(11):1749-1759.
In addition to premade arrays, arrays containing customized sets of antigens are available, as well as array processing kits, array profiling services and data analysis. Custom antigen arrays are also available. To inquire about a custom antigen array, please contact us.

Antigen microarray processing kits

GeneCopoeia’s OmicsArray™ Antigen Microarray Processing Kits for human and mouse contain all the reagents needed for users with a compatible microarray scanner (not included) to incubate samples (serum, plasma, cerebrospinal fluid. and other body fluids) with OmicsArray™ Antigen Microarrays: Hybridization and washing buffers, DNase I, DTT, and anti-human or anti-mouse labeled secondary antibodies (Cy3-IgG, Cy5-IgM). Slide trays and gaskets sold separately.
Prices are for customers from the U.S. and Canada only. For other customers, please contact your local distributor for details.
Buy Catalog number Description Price
PA100 OmicsArray™ Antigen Microarray Processing Kit, Human (for processing up to 4 slides) $250
PA101 OmicsArray™ Antigen Microarray Processing Kit, Mouse (for processing up to 4 slides) $250
PA102 OmicsArray™ 4-slide Tray and Gasket Set $325
PA103 OmicsArray™ 16-well Slide Gasket (pack of 2) $100
User Manual  SDS

Custom services

GeneCopoeia offers custom antigen microarray services in the following areas:
  • Custom array printing. GeneCopoeia will create custom antigen microarrays built to your specifications.
  • Sample processing. Send us your blood, plasma, tissue, or other biological sample and we will prepare it for processing and incubation with any of our premade antigen microarrays or custom-built antigen microarrays for autoantibody profiling and other applications. For information on sample types to submit, consult the FAQ
  • Data analysis. Once samples are processed and incubated with an antigen microarray, we will analyze the raw data. The standard analysis service includes: 1) An Excel file of the Net Signal Intensity (NSI) for each antigen on the array, normalized to internal controls; and 2) a heat map
Additional analysis services, including proteomic analysis, pathway analysis, and more, are also available.

To inquire about custom antigen microarray products and services, please fill out our custom quote request form.