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AAVPrime™ Adeno-associated Virus (AAV)

GeneCopoeia’s AAVPrime™ Adeno-associated virus (AAV) products are the ideal tools for inserting genes into a broad range of cell types with high efficiency and enhanced safety. GeneCopoeia’s optimized helper-free human AAV system allows viral packaging without potentially pathogenic helper adenovirus. Many pre-made AAV are available in 12 different serotypes, such as fluorescent reporters. You can also request us to produce custom AAV for genes up to 3 kb in length.

Advantages
  • High titers. Titer of purified AAV particles can be up to 1014 GC/ml.
  • High adaptability. All serotypes are available.
  • Versatile. Usable in a broad range of host cell types.
  • Low toxicity. Does not integrate into the host genome.
  • Low immunogenicity. Minimal host immune response.
  • Safe. Not associated with any human disease
Search all AAV products by gene ID or accession number

Custom AAV Order Information

We offer AAV of all serotypes with titers starting from 5×1012 GC/ml packaged with ORF, CRIPSR/Cas9 or shRNA. Click the links below to search for your gene(s) of interest.

For custom AAV packaging service, please contact us at inquiry@genecopoeia.com to get a quote.

Choose from our collection of AAV vectors with different promoters and fluorescent markers for your gene expression. The AAV can be packaged with ORF cDNA clones up to 3 kb in length for long-term expression.

AAV Vector List

Vector name Promoter Promoter description Reporter gene Max length of insertion
pEZ-AV01 CMV Strong promoter, broad scope of application. N/A 2.4 kb
pEZ-AV02 EF-1α Broad scope of application. Better choice than CMV for in vivo applications. N/A 3.2 kb
pEZ-AV04 CAG Ubiquitous. Better choice than CMV for in vivo applications. N/A 2 kb
pEZ-AV06 CBh Hybrid chicken beta actin promoter. Provides better long-term expression than CMV in neural cells. N/A 2.8 kb
pEZ-AV07 CMV Strong promoter, broad scope of application. IRES-eGFP 1.3 kb
pEZ-AV08 EF-1α Broad scope of application. Better choice than CMV for in vivo applications. IRES-eGFP 2 kb
pEZ-AV09 CAG Ubiquitous. Better choice than CMV for in vivo applications. IRES-eGFP 0.9 kb
pEZ-AV11 CBh Hybrid chicken beta actin promoter. Provides better long-term expression than CMV in neural cells. IRES-eGFP 1.7 kb
pEZ-AV12 CAMKlla Highly-specific expression in excitatory neurons in the neocortex and hippocampus. N/A 2.4 kb
pEZ-AV13 hSYN Human synapsin-1 gene promoter, neuronal-specific. N/A 3.2 kb
pEZ-AV15 MHC Cardiac muscle-specific human promoter. N/A 3.3 kb

We offer AAV packaged with

  • SaCas9 and sgRNA in all-in-one vector
  • sgRNA only (for SpCas9 or SaCas9)
  • SpCas9 or SaCas9 only coming soon

AAV CRIPSR Vectors

Vector name CRISPR Description Reporter gene
pCRISPR-AD01 SaCas9 & sgRNA All-in-one AAV vector with SaCas9 and sgRNA N/A
pCRISPR-AV20 sgRNA only AAV vector expressing sgRNA driven by U6 promoter N/A

Use AAV-shRNA for your gene knockdown experiments.

 

 

 

GeneCopoeia's AAVPrime™ standard AAV expressing fluorecent reporters

A B C
Figure 1. HT1080 cells in 24-well plates were transduced with 0.5 µL of standard purity AAV expressing either eGFP (A), RFP (B), or mCherry (C)). Cells were visualized with a fluorescence microscope (Exposure time: 400 ms).

GeneCopoeia's AAVPrime™ purified AAV expressing eGFP

0.005 μl 0.05 μl 0.5 μl
AAV-eGFP-0.005ul AAV-eGFP-0.05ul AAV-eGFP-0.5ul
Figure 2. HT1080 cells in 24-well plates were transduced with the indicated amounts of purified AAV expressing eGFP. Cells were visualized with a fluorescence microscope (Exposure time: 400 ms).

AAV Control Particles

Order AAV particles for controls and popular genes

NEW! AAV Serotype Testing Kit for testing which serotype works best for your cells.

By default, all options for AAV serotype, gene of interest, and volume are listed in the table below. Use the drop-down menus to narrow down the number of options displayed.

Serotype : Gene : Size :

Buy Catalog Size Product Description Gene of Interest Type Price
AA00125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
eGFPPurified$350
AA002100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
eGFPPurified$500
AA008500µl
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
eGFPStandard$300
AA0091ml
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
eGFPStandard$400
AA01125µl
≥ 5x10^12 GC/ml
IRES-eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
IRES-eGFPPurified$350
AA012100µl
≥ 5x10^12 GC/ml
IRES-eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
IRES-eGFPPurified$500
AA018500µl
≥ 1x10^11 GC/ml
IRES-eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
IRES-eGFPStandard$300
AA0191ml
≥ 1x10^11 GC/ml
IRES-eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
IRES-eGFPStandard$400
AA02125µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
LacZPurified$350
AA022100µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
LacZPurified$500
AA028500µl
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
LacZStandard$300
AA0291ml
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
LacZStandard$400
AA03125µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
CREPurified$350
AA032100µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
CREPurified$500
AA038500µl
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
CREStandard$300
AA0391ml
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
CREStandard$400
AA06125µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
mCherryPurified$350
AA062100µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
mCherryPurified$500
AA068500µl
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
mCherryStandard$300
AA0691ml
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
mCherryStandard$400
AA07125µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
FLucPurified$350
AA072100µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
FLucPurified$500
AA078500µl
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
FLucStandard$300
AA0791ml
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
FLucStandard$400
AA09125µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
GLucPurified$350
AA092100µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
GLucPurified$500
AA098500µl
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
GLucStandard$300
AA0991ml
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
GLucStandard$400
AA20125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
eGFPPurified$350
AA202100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
eGFPPurified$500
AA208500µl
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
eGFPStandard$300
AA2091ml
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
eGFPStandard$400
AA21125µl
≥ 5x10^12 GC/ml
IRES-eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
IRES-eGFPPurified$350
AA212100µl
≥ 5x10^12 GC/ml
IRES-eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
IRES-eGFPPurified$500
AA218500µl
≥ 1x10^11 GC/ml
IRES-eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
IRES-eGFPStandard$300
AA2191ml
≥ 1x10^11 GC/ml
IRES-eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
IRES-eGFPStandard$400
AA22125µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
LacZPurified$350
AA222100µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
LacZPurified$500
AA228500µl
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
LacZStandard$300
AA2291ml
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
LacZStandard$400
AA23125µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
CREPurified$350
AA232100µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
CREPurified$500
AA238500µl
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
CREStandard$300
AA2391ml
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
CREStandard$400
AA26125µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
mCherryPurified$350
AA262100µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
mCherryPurified$500
AA268500µl
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
mCherryStandard$300
AA2691ml
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
mCherryStandard$400
AA27125µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
FLucPurified$350
AA272100µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
FLucPurified$500
AA278500µl
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
FLucStandard$300
AA2791ml
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
FLucStandard$400
AA29125µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
GLucPurified$350
AA292100µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
GLucPurified$500
AA298500µl
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
GLucStandard$300
AA2991ml
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
GLucStandard$400
AA320
AAVPrime™ AAV Serotype Testing Kit.
Serotype: .   Promoter: CMV.
$795
AA40125µl
≥ 5x10^12GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ/8.   Promoter: CMV.
eGFPPurified$350
AA402100µl
≥ 5x10^12GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ/8.   Promoter: CMV.
eGFPPurified$500
AA408500µl
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
eGFPStandard$360
AA4091ml
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
eGFPStandard$480
AA41125µl
≥ 5x10^12GC/ml
IRES-eGFP Purified AAVPrime™ Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ/8.   Promoter: CMV.
IRES-eGFPPurified$350
AA412100µl
≥ 5x10^12GC/ml
IRES-eGFP Purified AAVPrime™ Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ/8.   Promoter: CMV.
IRES-eGFPPurified$500
AA418500µl
≥ 1x10^11 GC/ml
IRES-eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
IRES-eGFPStandard$360
AA4191ml
≥ 1x10^11 GC/ml
IRES-eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
IRES-eGFPStandard$480
AA42125µl
≥ 5x10^12GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ/8.   Promoter: CMV.
LacZPurified$350
AA422100µl
≥ 5x10^12GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ/8.   Promoter: CMV.
LacZPurified$500
AA428500µl
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
LacZStandard$360
AA4291ml
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
LacZStandard$480
AA43125µl
≥ 5x10^12GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ/8.   Promoter: CMV.
CREPurified$350
AA432100µl
≥ 5x10^12GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ/8.   Promoter: CMV.
CREPurified$500
AA438500µl
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
CREStandard$360
AA4391ml
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
CREStandard$480
AA46125µl
≥ 5x10^12GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ/8.   Promoter: CMV.
mCherryPurified$350
AA462100µl
≥ 5x10^12GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ/8.   Promoter: CMV.
mCherryPurified$500
AA468500µl
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
mCherryStandard$360
AA4691ml
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
mCherryStandard$480
AA47125µl
≥ 5x10^12GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ/8.   Promoter: CMV.
FLucPurified$350
AA472100µl
≥ 5x10^12GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ/8.   Promoter: CMV.
FLucPurified$500
AA478500µl
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
FLucStandard$360
AA4791ml
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
FLucStandard$480
AA49125µl
≥ 5x10^12GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ/8.   Promoter: CMV.
GLucPurified$350
AA492100µl
≥ 5x10^12GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ/8.   Promoter: CMV.
GLucPurified$500
AA498500µl
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
GLucStandard$360
AA4991ml
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
GLucStandard$480
AA60125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 1.   Promoter: CMV.
eGFPPurified$350
AA602100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 1.   Promoter: CMV.
eGFPPurified$500
AA80125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 3.   Promoter: CMV.
eGFPPurified$350
AA802100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 3.   Promoter: CMV.
eGFPPurified$500
AB40125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 6.   Promoter: CMV.
eGFPPurified$350
AB402100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 6.   Promoter: CMV.
eGFPPurified$500
AB60125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 7.   Promoter: CMV.
eGFPPurified$350
AB602100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 7.   Promoter: CMV.
eGFPPurified$500
AB80125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 8.   Promoter: CMV.
eGFPPurified$350
AB802100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 8.   Promoter: CMV.
eGFPPurified$500
AC00125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 9.   Promoter: CMV.
eGFPPurified$350
AC002100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 9.   Promoter: CMV.
eGFPPurified$500

 

 

 

AAV Technology Overview

Custom AAV Production with the AAVPrimeTM System

AAVPrime™ uses a helper virus-free system for the safe preparation of high titer AAV. HEK293T cells are co-transfected with three plasmids encoding the factors necessary for recombinant AAV packaging (Right Figure). and purify AAV particles are either membrane purified or purified by two-phase partitioning for high-titer AAV ready for in vivo animal use.

AAV packaging plasmids

The destination vector carries your gene of interest (GOI) and two ITRs. You can choose from a variety of destination vectors carrying promoters including CMV, EF1a, CAG, CBh and tissue-specific promoters, and reporter gene GFP for optimal gene expression and detection. (Learn more about our vector collection); the plasmid that carries the Rep and Cap genes from wild type AAV and the plasmid that carries adenovirus VA, E4 and E2A genes required for efficient AAV production are co-transfected with the destination vector for AAV packaging.

AAV Serotype Choices

GeneCopoeia provides AAV for all the commonly-occurring AAV serotypes, including AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV-DJ and AAV-DJ/8. The intensity of gene expression and tissue tropism depends highly on the AAV serotype used in different tissues.

Different serotypes differ mainly in surface protein (capsid). Carefully choosing the serotype enables robust gene expression in specific tissues with minimal immune response. Refer to the table below to compare the essential differences between different serotypes.

AAV Serotypes Available

Serotype Primary Target Tissues Description
AAV-1 Muscle Best for cardiac muscle, skeletal muscle, neuronal and glial tissue.
AAV-2 Muscle, Liver, Retina Oldest and most commonly-used serotype. Best for neurons, muscle, liver, and brain.
AAV-3 Megakaryocytes Best for megakaryocytes, muscle, liver, lung, and retina.
AAV-4 Retina Best for neurons, muscle, brain, and retina.
AAV-5 Lung Best for lung, neurons, synovial joint, retina, and pancreas.
AAV-6 Muscle, Lung Best for lung, liver, and heart.
AAV-7 Muscle, Retina, Neurons Best for muscle, neurons, and liver.
AAV-8 Liver Best for muscle, brain, liver, and retina.
AAV-9 Various Best for muscle, heart, liver, lung, and brain.
AAV-10 Pleura, CNS Cloned from Cynomolgus, almost identical with AAVrh10 except for 12 amino acids in VP1. Best for lung, muscle, heart, CNS, and liver.
AAV-DJ Various A mixture of 8 naturally-occurring serotypes. Efficiently transduces a wide variety of cell types in vitro.
AAV-DJ/8 Various A variant of AAV-DJ with a mutation that permits infection of liver as well as other tissues in vivo.

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