You are here: Home > Products > AAV >

AAVPrime™ Adeno-associated Virus (AAV)

GeneCopoeia’s AAVPrime™ Adeno-associated virus (AAV) products are the ideal tools for expressing or modifying genes in a broad range of cell and tissue types, especially in vivo, with high efficiency and enhanced safety. GeneCopoeia’s optimized helper-free human AAV system allows viral packaging without potentially pathogenic helper adenovirus. Many pre-made AAV are available in 12 different serotypes, such as fluorescent reporters. You can also request us to produce custom AAV for genes up to 3 kb in length.

  • High titers. Titer of purified AAV particles can be up to 1014 GC/ml.
  • High adaptability. Virtually all serotypes are available.
  • Versatile. Usable in a broad range of host cell and tissue types.
  • Low toxicity. Does not integrate into the host genome.
  • Low immunogenicity. Minimal host immune response.
  • Safe. Not associated with any human disease
Search all AAV products by gene ID or accession number

Custom AAV

We offer AAV of virtually all serotypes with titers starting from 5×1012 GC/ml packaged with ORF, CRISPR/Cas9 or shRNA. Click the links below to search for your gene(s) of interest.

For custom AAV packaging service, please contact us at inquiry@genecopoeia.com to get a quote.

AAV-ORF cDNA

Choose from our collection of AAV vectors with different promoters and fluorescent markers for your gene expression. The AAV can be packaged with ORF cDNA clones up to 3 kb in length for long-term expression.

AAV Vector List

Vector name Promoter Promoter description Reporter gene Max length of insertion
pEZ-AV01 CMV Strong promoter, broad scope of application. N/A 2.4 kb
pEZ-AV02 EF-1α Broad scope of application. Better choice than CMV for in vivo applications. N/A 3.2 kb
pEZ-AV04 CAG Ubiquitous. Better choice than CMV for in vivo applications. N/A 2 kb
pEZ-AV06 CBh Hybrid chicken beta actin promoter. Provides better long-term expression than CMV in neural cells. N/A 2.8 kb
pEZ-AV07 CMV Strong promoter, broad scope of application. IRES-eGFP 1.3 kb
pEZ-AV08 EF-1α Broad scope of application. Better choice than CMV for in vivo applications. IRES-eGFP 2 kb
pEZ-AV09 CAG Ubiquitous. Better choice than CMV for in vivo applications. IRES-eGFP 0.9 kb
pEZ-AV11 CBh Hybrid chicken beta actin promoter. Provides better long-term expression than CMV in neural cells. IRES-eGFP 1.7 kb
pEZ-AV12 CAMKlla Highly-specific expression in excitatory neurons in the neocortex and hippocampus. N/A 2.4 kb
pEZ-AV13 hSYN Human synapsin-1 gene promoter, neuronal-specific. N/A 3.2 kb
pEZ-AV15 MHC Muscle-specific human promoter. N/A 3.3 kb
pEZ-AV18 MCK Cardiac muscle-specific human promoter. N/A 3.0 kb
pEZ-AV24 MBP Oligodendrocyte-specific expression in central nervous system. N/A 3.0 kb
pEZ-AV33 ALB Liver-specific human promoter. N/A 2.0 kb

AAV-CRISPR

We offer AAV packaged with

  • SaCas9 and sgRNA in all-in-one vector
  • sgRNA only (for SpCas9 or SaCas9)
  • SpCas9 or SaCas9 only coming soon

AAV CRISPR Vectors

Vector name CRISPR Description Reporter gene
pCRISPR-AD01 SaCas9 & sgRNA All-in-one AAV vector with SaCas9 and sgRNA N/A
pCRISPR-AV20 sgRNA only AAV vector expressing sgRNA driven by U6 promoter N/A

 

AAV-shRNA

Transduction-ready AAV delivering shRNA of varying lengths (19 to 29 bases) that were designed using a proprietary algorithm to make shRNA expression constructs that have high knockdown efficiency with minimal off-target effect.

Vector Promoter Selection Marker Reporter Gene Viral type
psi-AV03 U6 N/A N/A AAV
psi-AVE001 CMV N/A eGFP AAV
psi-AVE002 CMV N/A mCherry AAV
psi-AVE003 EF1a N/A eGFP AAV
psi-AVE004 EF1a N/A mCherry AAV

 

Request a quote for custom pol III or pol II promoter-driven shRNA AAV services.

 

AAV-miRNA

Transduction-ready AAV delivering miRNA inhibitors or precursors.

miRNA Precursor AAV particles
Vector
Tracking gene
Selection marker
Promoter
Type
pEZX-MR14 eGFP Puromycin CMV AAV
pEZX-MR15 mCherry Puromycin CMV AAV
 

 

miRNA Inhibitor AAV particles
Vector
Tracking gene
Selection marker
Promoter
Type
pEZX-AM06 mCherry Hygromycin H1 AAV
pEZX-AM07 mCherry Hygromycin U6 AAV
 

 

Please contact inquiry@genecopoeia.com regarding to miRNA cloning and AAV packaging services.