GeneHero™ CRISPRi Stable Cell Lines

Product Information
GeneHero™ CRISPRi Stable Cell Lines are mammalian cell lines stably expressing dCas9-KRAB fusion protein for the study of transcriptional inhibition of endogenous genes. These CRISPRi cell lines have stably integrated human codon-optimized dCas9 fused to a transcriptional repressor peptide KRAB to silence target gene expression.
The cell lines are monoclonal with verified dCas9-KRAB genome integration and expression. Simply introduce promoter-targeting sgRNA or CRISPRi sgRNA libraries into the CRISPRi cell lines. They are ideal for the study of gene expression inhibition and genetic screening.
CRISPRi Transcription inhibition by CRISPRi cell line expressing dCas9-KRAS