All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

sgRNA for CRISPRa and CRISPRi

CRISPR activation (CRISPRa) and interference (CRISPRi) are advanced genetic tools that utilize a catalytically “dead” Cas9 (dCas9) fused to effector proteins to modulate gene expression without cutting or altering the underlying DNA sequence. These technologies offer superior precision, reduced toxicity, and greater flexibility for regulating endogenous genes compared to traditional knockouts or cDNA overexpression.

GeneCopoeia’s CRISPR products and services provide a complete, powerful solution to your epigenetic editing needs.

sgRNA for CRISPR activation

Vector choices for expression clones and lentivirus particles

Vector	Promoter	CRISPR option	Selection Marker / Reporter Gene	Vector Type	Vector Map
pCRISPR-AG01	U6	CRISPRa dCas9 SAM	Puro / eGFP	Lentiviral
pCRISPR-AG02	U6	CRISPRa dCas9 SAM	Puro / eGFP	Lentiviral

sgRNA for CRISPR interference

Vector choices for expression clones and lentivirus particles

Vector	Promoter	CRISPR option	Selection Marker / Reporter Gene	Vector Type	Vector Map
pCRISPR-AB04	U6	CRISPRi dCas9-KRAB	Puro / mCherry	Lentiviral

sgRNA for CRISPRa and CRISPRi

Activate the transcription of any endogenous gene of interest, without cutting the DNA

Vector choices for expression clones and lentivirus particles

Repress gene expression, without cutting the DNA

Vector choices for expression clones and lentivirus particles