Cancer driver gene

Introduction

Cancer is a collection of diseases characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Based on their role in cancer progression, driver genes can be classified into two main categories: oncogenes and tumor suppressor genes. Oncogene addiction refers to the phenomenon that certain tumours depend on one or more activated oncogenes, also known as driver oncogenes, to maintain their malignant biological phenotype.
For example, EGFR gene mutation is a common mutation in lung cancer, which makes the EGFR receptor persistently activated and the signalling process aberrant, leading to long-term uncontrolled cell proliferation and growth, and becoming one of the driver genes of lung cancer cells. Cancer cells require driver oncogenes for sustained function, whereas normal cells do not.
Therefore, targeting oncogenes as therapeutic targets allows targeted drugs to specifically kill tumour cells without damaging normal cells. Martínez-Jiménez et al. present the Integrative OncoGenomics (IntOGen) pipeline, which applies to somatic mutations of more than 28,000 tumours of 66 cancer types reveals 568 cancer genes and points towards their mechanisms of tumorigenesis. These cancer driver genes’ identification has led to the development of the paradigm of targeted anticancer therapies and, more generally, to the search for genomic biomarkers of prognosis and response to treatments.

Clone set information

Cat. no. Species Gene Vector Vector Type Price
OC-GF022-M02 Human 620 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF022-M35 Human 620 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF022-M98 Human 620 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF022-Lv105 Human 620 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF022-Lv242 Human 620 pReceiver-Lv242 Expression-ready Lentiviral Inquire
OC-GF022-GC Human 620 pDONR™ Vector Gateway shuttle Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
AR NM_000044.6 Human Homo sapiens androgen receptor (AR), transcript variant 1, mRNA. 2763 GC-E2325
AR NM_001011645.3 Human Homo sapiens androgen receptor (AR), transcript variant 2, mRNA. 1167 GC-E2336
TAL1 NM_003189.2 Human Homo sapiens T-cell acute lymphocytic leukemia 1 (TAL1), mRNA. 996 GC-Z7474
ASXL2 NM_018263.6 Human Homo sapiens ASXL transcriptional regulator 2 (ASXL2), transcript variant 1, mRNA. 4308 GC-H1988
KLHL6 NM_130446.4 Human Homo sapiens kelch like family member 6 (KLHL6), mRNA. 1866 GC-H0299
BIRC3 NM_001165.5 Human Homo sapiens baculoviral IAP repeat containing 3 (BIRC3), transcript variant 1, mRNA. 1815 GC-Z7357
PSIP1 NM_001128217.3 Human Homo sapiens PC4 and SFRS1 interacting protein 1 (PSIP1), transcript variant 3, mRNA. 1593 GC-Z6352
AKT1 NM_001014431.2 Human Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 3, mRNA. 1443 GC-Z5980
TFG NM_001007565.2 Human Homo sapiens trafficking from ER to golgi regulator (TFG), transcript variant 2, mRNA. 1203 GC-Z5959
SDCBP NM_001007067.2 Human Homo sapiens syndecan binding protein (SDCBP), transcript variant 2, mRNA. 897 GC-Z5957
IDH1 NM_005896.4 Human Homo sapiens isocitrate dehydrogenase (NADP(+)) 1 (IDH1), transcript variant 1, mRNA. 1245 GC-A1413
ANK1 NM_000037.4 Human Homo sapiens ankyrin 1 (ANK1), transcript variant 3, mRNA. 5643 GC-Z5852
FAS NM_000043.6 Human Homo sapiens Fas cell surface death receptor (FAS), transcript variant 1, mRNA. 1008 GC-G0198
BLM NM_000057.4 Human Homo sapiens BLM RecQ like helicase (BLM), transcript variant 1, mRNA. 4254 GC-S0514
BTK NM_000061.3 Human Homo sapiens Bruton tyrosine kinase (BTK), transcript variant 1, mRNA. 1980 GC-A0534
CDK4 NM_000075.4 Human Homo sapiens cyclin dependent kinase 4 (CDK4), mRNA. 912 GC-T1758
CDKN2A NM_000077.5 Human Homo sapiens cyclin dependent kinase inhibitor 2A (CDKN2A), transcript variant 1, mRNA. 471 GC-T1759
COL1A1 NM_000088.4 Human Homo sapiens collagen type I alpha 1 chain (COL1A1), mRNA. 4395 GC-A3481
DDB2 NM_000107.3 Human Homo sapiens damage specific DNA binding protein 2 (DDB2), transcript variant WT, mRNA. 1284 GC-S0502
ERCC3 NM_000122.2 Human Homo sapiens ERCC excision repair 3, TFIIH core complex helicase subunit (ERCC3), transcript variant 1, mRNA. 2349 GC-Q0554
ESR1 NM_000125.3 Human Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1, mRNA. 1788 GC-A0322
FANCC NM_000136.3 Human Homo sapiens FA complementation group C (FANCC), transcript variant 1, mRNA. 1677 GC-Z3090
FGFR2 NM_000141.5 Human Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1, mRNA. 2466 GC-A0979
FGFR3 NM_000142.4 Human Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mRNA. 2421 GC-M0098
FH NM_000143.4 Human Homo sapiens fumarate hydratase (FH), mRNA; nuclear gene for mitochondrial product. 1533 GC-T3095
JAK3 NM_000215.4 Human Homo sapiens Janus kinase 3 (JAK3), mRNA. 3375 GC-Z2520
KIT NM_000222.3 Human Homo sapiens KIT proto-oncogene, receptor tyrosine kinase (KIT), transcript variant 1, mRNA. 2931 GC-A0519
MET NM_000245.4 Human Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), transcript variant 2, mRNA. 4173 GC-H0648
CIITA NM_000246.4 Human Homo sapiens class II major histocompatibility complex transactivator (CIITA), transcript variant 2, mRNA. 3393 GC-F0490
PTCH1 NM_000264.5 Human Homo sapiens patched 1 (PTCH1), transcript variant 1b, mRNA. 4344 GC-T0559
PTEN NM_000314.8 Human Homo sapiens phosphatase and tensin homolog (PTEN), transcript variant 1, mRNA. 1212 GC-I0450
RB1 NM_000321.3 Human Homo sapiens RB transcriptional corepressor 1 (RB1), mRNA. 2787 GC-B0065
SOX9 NM_000346.4 Human Homo sapiens SRY-box transcription factor 9 (SOX9), mRNA. 1530 GC-M0312
TSC1 NM_000368.5 Human Homo sapiens TSC complex subunit 1 (TSC1), transcript variant 1, mRNA. 3495 GC-K2992
WAS NM_000377.3 Human Homo sapiens WASP actin nucleation promoting factor (WAS), mRNA. 1509 GC-G0710
ERCC2 NM_000400.4 Human Homo sapiens ERCC excision repair 2, TFIIH core complex helicase subunit (ERCC2), transcript variant 1, mRNA. 2283 GC-T3631
STK11 NM_000455.5 Human Homo sapiens serine/threonine kinase 11 (STK11), mRNA. 1302 GC-T0511
BARD1 NM_000465.4 Human Homo sapiens BRCA1 associated RING domain 1 (BARD1), transcript variant 1, mRNA. 2334 GC-Q0613
ELN NM_000501.4 Human Homo sapiens elastin (ELN), transcript variant 1, mRNA. 2175 GC-Z3993
GNAS NM_000516.7 Human Homo sapiens GNAS complex locus (GNAS), transcript variant 1, mRNA. 1185 GC-A1008
TP53 NM_000546.6 Human Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. 1182 GC-B0105
TSC2 NM_000548.5 Human Homo sapiens TSC complex subunit 2 (TSC2), transcript variant 1, mRNA. 5424 GC-Z5884
VHL NM_000551.4 Human Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA. 642 GC-K5438
CD79B NM_000626.4 Human Homo sapiens CD79b molecule (CD79B), transcript variant 1, mRNA. 690 GC-Z5892
BCL2 NM_000633.3 Human Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant alpha, mRNA. 720 GC-H3307
BCL2 NM_000657.3 Human Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant beta, mRNA. 618 GC-I1432
ALDH2 NM_000690.4 Human Homo sapiens aldehyde dehydrogenase 2 family member (ALDH2), transcript variant 1, mRNA; nuclear gene for mitochondrial product. 1554 GC-C0231
ATP1A1 NM_000701.8 Human Homo sapiens ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1), transcript variant 1, mRNA. 3072 GC-T0533
CSF3R NM_000760.4 Human Homo sapiens colony stimulating factor 3 receptor (CSF3R), transcript variant 1, mRNA. 2511 GC-Z2501
CYP2C8 NM_000770.3 Human Homo sapiens cytochrome P450 family 2 subfamily C member 8 (CYP2C8), transcript variant 1, mRNA. 1473 GC-X0605