All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

Histone modification enzymes

Introduction

Histone modification refers to the dynamic process by which histones are modified through methylation, acetylation, phosphorylation, adenylation, ubiquitination, ADP-ribosylation and other processes which are facilitated by specific enzymes.

Histone modifying enzymes include: histone acetyltransferase HAT and histone deacetylase HDAC for controlling acetylation; histone methyltransferases HMTs/KMTs, protein arginine methyltransferases PRMTs, and lysine demethylases KDMs for methylation; ubiquitylating histone ubiquitin ligases and deubiquitylating enzymes, etc. Histone modifications are one of the major forms of epigenetics and play an important role in the regulation of genetic expression and phenotype. For example, histone modifications regulate the expression of nervous system-associated genes, which are involved in the normal function of the nervous system, adaptive regulation, and neurodegenerative diseases, with different roles depending on the type of histone modification.

Clone set information

Cat. No.	Old Cat. No.	Species	Gene	Vector	Vector Type	Price
OC-GF009-M02	OC-HHM-M02	Human	107	pReceiver-M02	Expression-ready Non-viral	Inquire
OC-GF009-M35	OC-HHM-M35	Human	107	pReceiver-M35	Expression-ready Non-viral	Inquire
OC-GF009-M98	OC-HHM-M98	Human	107	pReceiver-M98	Expression-ready Non-viral	Inquire
OC-GF009-Lv105	OC-HHM-Lv105	Human	107	pReceiver-Lv105	Expression-ready Lentiviral	Inquire
OC-GF009-Lv242	OC-HHM-Lv242	Human	107	pReceiver-Lv242	Expression-ready Lentiviral	Inquire
OC-GF009-GC	OC-HHM-GC	Human	107	pDONR™ Vector	Gateway shuttle	Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.

Symbol	Accession	Species	Description	ORF length(bp)	Product ID
KDM6B	NM_001080424.2	Human	Homo sapiens lysine demethylase 6B (KDM6B), transcript variant 1, mRNA.	5049	GC-H3266
CDY2B	NM_001001722.2	Human	Homo sapiens chromodomain Y-linked 2B (CDY2B), mRNA.	1626	GC-X0133
KDM1A	NM_001009999.3	Human	Homo sapiens lysine demethylase 1A (KDM1A), transcript variant 1, mRNA.	2631	GC-E2594
HDAC5	NM_001015053.2	Human	Homo sapiens histone deacetylase 5 (HDAC5), transcript variant 3, mRNA.	3372	GC-Z4127
AK6	NM_001015891.2	Human	Homo sapiens adenylate kinase 6 (AK6), transcript variant 3, mRNA.	510	GC-Z2572
TAF5L	NM_001025247.2	Human	Homo sapiens TATA-box binding protein associated factor 5 like (TAF5L), transcript variant 2, mRNA.	978	GC-Z1945
PRMT5	NM_001039619.3	Human	Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 2, mRNA.	1863	GC-Z4222
KDM5A	NM_001042603.3	Human	Homo sapiens lysine demethylase 5A (KDM5A), mRNA.	5073	GC-H3429
JMJD6	NM_001081461.2	Human	Homo sapiens jumonji domain containing 6, arginine demethylase and lysine hydroxylase (JMJD6), transcript variant 1, mRNA.	1245	GC-E2359
PRDM7	NM_001098173.2	Human	Homo sapiens PR/SET domain 7 (PRDM7), mRNA.	1479	GC-H1723
HDAC7	NM_001098416.4	Human	Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 4, mRNA.	2865	GC-Z1602
PRDM6	NM_001136239.4	Human	Homo sapiens PR/SET domain 6 (PRDM6), mRNA.	1788	GC-H3221
OGA	NM_001142434.2	Human	Homo sapiens O-GlcNAcase (OGA), transcript variant 2, mRNA.	2592	GC-Z6693
SIRT1	NM_001142498.2	Human	Homo sapiens sirtuin 1 (SIRT1), transcript variant 2, mRNA.	1359	GC-Z6705
SETDB1	NM_001145415.2	Human	Homo sapiens SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), transcript variant 1, mRNA.	3876	GC-A1659
KDM3A	NM_001146688.2	Human	Homo sapiens lysine demethylase 3A (KDM3A), transcript variant 2, mRNA.	3966	GC-T3698
KDM4C	NM_001146695.4	Human	Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 3, mRNA.	2442	GC-Z7106
KDM4C	NM_001146696.2	Human	Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 4, mRNA.	2508	GC-H4294
KDM5C	NM_001146702.2	Human	Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 2, mRNA.	4140	GC-Z7107
KDM5D	NM_001146705.2	Human	Homo sapiens lysine demethylase 5D (KDM5D), transcript variant 1, mRNA.	4713	GC-H4296
KDM5D	NM_001146706.2	Human	Homo sapiens lysine demethylase 5D (KDM5D), transcript variant 3, mRNA.	4449	GC-H4297
KDM4E	NM_001161630.1	Human	Homo sapiens lysine demethylase 4E (KDM4E), mRNA.	1521	GC-H4383
TADA2A	NM_001166105.3	Human	Homo sapiens transcriptional adaptor 2A (TADA2A), transcript variant 3, mRNA.	1332	GC-T3054
SMYD3	NM_001167740.2	Human	Homo sapiens SET and MYND domain containing 3 (SMYD3), transcript variant 1, mRNA.	1287	GC-H9002
NCOA3	NM_001174087.2	Human	Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 3, mRNA.	4272	GC-Z9892
NCOA3	NM_001174088.2	Human	Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 4, mRNA.	4248	GC-Z9893
SIRT2	NM_001193286.2	Human	Homo sapiens sirtuin 2 (SIRT2), transcript variant 3, mRNA.	705	GC-H8904
SUV39H2	NM_001193424.2	Human	Homo sapiens SUV39H2 histone lysine methyltransferase (SUV39H2), transcript variant 1, mRNA.	1233	GC-H8696
SUV39H2	NM_001193426.2	Human	Homo sapiens SUV39H2 histone lysine methyltransferase (SUV39H2), transcript variant 4, mRNA.	693	GC-T7836
SUV39H2	NM_001193427.2	Human	Homo sapiens SUV39H2 histone lysine methyltransferase (SUV39H2), transcript variant 5, mRNA.	513	GC-Z9201
KAT7	NM_001199155.1	Human	Homo sapiens lysine acetyltransferase 7 (KAT7), transcript variant 2, mRNA.	1746	GC-H9355
KAT7	NM_001199156.1	Human	Homo sapiens lysine acetyltransferase 7 (KAT7), transcript variant 3, mRNA.	1419	GC-H9358
KAT7	NM_001199157.1	Human	Homo sapiens lysine acetyltransferase 7 (KAT7), transcript variant 4, mRNA.	1506	GC-H9356
KAT7	NM_001199158.1	Human	Homo sapiens lysine acetyltransferase 7 (KAT7), transcript variant 5, mRNA.	1329	GC-H9357
EZH2	NM_001203247.2	Human	Homo sapiens enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), transcript variant 3, mRNA.	2241	GC-A2944
EZH2	NM_001203248.2	Human	Homo sapiens enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), transcript variant 4, mRNA.	2214	GC-Z9318
KAT5	NM_001206833.2	Human	Homo sapiens lysine acetyltransferase 5 (KAT5), transcript variant 4, mRNA.	1485	GC-A2145
SETDB1	NM_001243491.2	Human	Homo sapiens SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), transcript variant 3, mRNA.	1194	GC-A2149
KDM2A	NM_001256405.2	Human	Homo sapiens lysine demethylase 2A (KDM2A), transcript variant 3, mRNA.	2172	GC-A1988
KAT6B	NM_001256469.2	Human	Homo sapiens lysine acetyltransferase 6B (KAT6B), transcript variant 3, mRNA.	5346	GC-A2103
SUPT3H	NM_001261823.2	Human	Homo sapiens SPT3 homolog, SAGA and STAGA complex component (SUPT3H), transcript variant 3, mRNA.	498	GC-A2725
JARID2	NM_001267040.1	Human	Homo sapiens jumonji and AT-rich interaction domain containing 2 (JARID2), transcript variant 2, mRNA.	3225	GC-A2742
CLOCK	NM_001267843.2	Human	Homo sapiens clock circadian regulator (CLOCK), transcript variant 1, mRNA.	2541	GC-U0240
KDM5C	NM_001282622.3	Human	Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 3, mRNA.	4680	GC-Z1005
HDAC6	NM_001321230.2	Human	Homo sapiens histone deacetylase 6 (HDAC6), transcript variant 7, mRNA.	441	GC-V0819
HDAC9	NM_001321895.2	Human	Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 33, mRNA.	1650	GC-E3125
HDAC9	NM_001321896.2	Human	Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 34, mRNA.	1689	GC-E3148
HDAC2	NM_001527.4	Human	Homo sapiens histone deacetylase 2 (HDAC2), transcript variant 1, mRNA.	1467	GC-Z8312
EZH1	NM_001991.5	Human	Homo sapiens enhancer of zeste 1 polycomb repressive complex 2 subunit (EZH1), transcript variant 1, mRNA.	2244	GC-M0269
SUV39H1	NM_003173.4	Human	Homo sapiens SUV39H1 histone lysine methyltransferase (SUV39H1), transcript variant 2, mRNA.	1239	GC-U1202