ERSE transcriptional response element (TRE) clone

ERSE transcriptional response element(TRE) clone for ER stress pathway
ERSE transcriptional response element(TRE) clone for ER stress pathway
Transcriptional response element(TRE) negative control clone
Transcriptional response element(TRE) negative control clone
GAPDH positive control clone
GAPDH positive control clone
Secreted alkaline phosphatase (SEAP)<br />Expression clone
Secreted alkaline phosphatase (SEAP)
Expression clone

ERSE transcriptional response element(TRE) clone for ER stress pathway Transcriptional response element(TRE) negative control clone GAPDH positive control clone Secreted alkaline phosphatase (SEAP)
Expression clone

Price: $350.00 $350.00 $375.00 $395.00
Catalog#:
  • TR110
  • TR001
  • GAPDH-PG02
  • SEAP-PA01
Size: pEZX-PG02 pEZX-PG02 pEZX-PG02 pEZX-PA01
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Introduction GeneCopoeia provides the GLuc-ON™ ERSE transcriptional response element (TRE) clone for analysis of the response to endoplasmic reticulum (ER) stress resulting from the unfolded protein response. The ER stress response element (ERSE) is activated by several transcription factors, namely ATF6, to induce genes that express proteins that clear the cell of misfolded and unfolded proteins. In cases of prolonged ER stress, the pathway induces apoptosis. Malfunction of the ER stress pathway leads to diseases such as Huntingtin’s disease and diabetes. The GLuc-ON™ MEF2 ERSE clone contains tandem repeats of an ERSE binding site upstream of a minimal promoter and secreted Gaussia luciferase reporter gene, which allows robust and sensitive analysis without lysing the cells.  The ERSE response elements are engineered to provide strong activation with low background (Figure 1). The GLuc-ON™ ERSE TRE clone is provided as transfection-ready DNA. Negative (non-activating), positive (constitutively-activted) and normalization (secreated alkaline phosphatase) control clones are also available for purchase.