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Synaptic genes in autoimmune disease of nervous system

Introduction

The nervous system includes the central nervous system (CNS) and the peripheral nervous system (PNS). Viral infections, poisoning, genetic defects, immune damage, and metabolic disorders may trigger the development of neurological diseases. Neurological autoimmune diseases are diseases in which the body’s immune system mistakenly attacks its own nervous system, causing damage to the tissue structure and function of the nervous system. This kind of disease has a wide range of damage, and the clinical manifestations are complex and varied, which can involve the central nervous system, peripheral nervous system and nerve-muscle joints, resulting in neuronal or axonal damage, myelin loss, nerve-muscle joint destruction and other pathological changes.
Examples of CNS autoimmune diseases include optic neuromyelitis optica spectrum disease (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), autoimmune encephalitis (AE), and vasculitis of the CNS. These diseases have relatively independent clinical features, and some specific antibodies play an indispensable role in the diagnosis and differential diagnosis of the diseases. For example, patients with NMOSD may be positive for AQP4 antibodies, and patients with ADEM may be positive for MOG antibodies.
This clone set can be used for the development of biomarkers for neuroimmune diseases, expanding and improving the spectrum of humoral markers for neuroimmune diseases, which can be further used for differential diagnosis, disease course monitoring, efficacy and prognosis assessment, and drug target screening.

Clone set information

Cat. no. Species Gene Vector Vector Type Price
OC-GF021-M02 Human 2137 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF021-M35 Human 2137 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF021-M98 Human 2137 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF021-Lv105 Human 2137 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF021-Lv242 Human 2137 pReceiver-Lv242 Expression-ready Lentiviral Inquire
OC-GF021-GC Human 2137 pDONR™ Vector Gateway shuttle Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
PRNP NM_001271561.3 Human Homo sapiens prion protein (PRNP), transcript variant 2, mRNA. 222 GC-I1624
CAMK4 NM_001744.4 Human Homo sapiens calcium/calmodulin-dependent protein kinase IV (CAMK4), mRNA. 1422 GC-A0231
MAPRE3 NM_012326.2 Human Homo sapiens microtubule-associated protein, RP/EB family, member 3 (MAPRE3), mRNA. 846 GC-U1078
SH3GLB2 NM_020145.2 Human Homo sapiens SH3-domain GRB2-like endophilin B2 (SH3GLB2), mRNA. 1188 GC-W0833
PSD2 NM_032289.4 Human Homo sapiens pleckstrin and Sec7 domain containing 2 (PSD2), mRNA. 2316 GC-T1548
HCRTR2 NM_001526.5 Human Homo sapiens hypocretin receptor 2 (HCRTR2), transcript variant 2, mRNA. 1335 GC-U0063
TSC22D4 NM_030935.3 Human Homo sapiens TSC22 domain family, member 4 (TSC22D4), mRNA. 1188 GC-P0111
RPL36 NM_015414.4 Human Homo sapiens ribosomal protein L36 (RPL36), transcript variant 2, mRNA. 318 GC-Z7715
SPARCL1 NM_001128310.3 Human Homo sapiens SPARC like 1 (SPARCL1), transcript variant 1, mRNA. 1995 GC-Z6357
DMTN NM_001114137.4 Human Homo sapiens dematin actin binding protein (DMTN), transcript variant 4, mRNA. 1152 GC-Z6228
ELK1 NM_001114123.3 Human Homo sapiens ETS transcription factor ELK1 (ELK1), transcript variant 1, also known as 5'UTR long or 5'UTRL, mRNA. 1287 GC-Z6227
AKT1 NM_001014431.2 Human Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 3, mRNA. 1443 GC-Z5980
SDCBP NM_001007067.2 Human Homo sapiens syndecan binding protein (SDCBP), transcript variant 2, mRNA. 897 GC-Z5957
RPL34 NM_000995.5 Human Homo sapiens ribosomal protein L34 (RPL34), transcript variant 1, mRNA. 354 GC-Z5916
RPL13 NM_000977.4 Human Homo sapiens ribosomal protein L13 (RPL13), transcript variant 1, mRNA. 636 GC-Z5915
SLC30A7 NM_001144884.2 Human Homo sapiens solute carrier family 30 member 7 (SLC30A7), transcript variant 2, mRNA. 1131 GC-H4073
GIPC1 NM_202470.3 Human Homo sapiens GIPC PDZ domain containing family member 1 (GIPC1), transcript variant 5, mRNA. 1002 GC-A1523
KCNJ15 NM_170737.3 Human Homo sapiens potassium inwardly rectifying channel subfamily J member 15 (KCNJ15), transcript variant 3, mRNA. 1128 GC-A1517
RPS3 NM_001005.5 Human Homo sapiens ribosomal protein S3 (RPS3), transcript variant 1, mRNA. 732 GC-A1500
IDH1 NM_005896.4 Human Homo sapiens isocitrate dehydrogenase (NADP(+)) 1 (IDH1), transcript variant 1, mRNA. 1245 GC-A1413
PRNP NM_000311.5 Human Homo sapiens prion protein (PRNP), transcript variant 1, mRNA. 762 GC-I2265
GNAZ NM_002073.4 Human Homo sapiens G protein subunit alpha z (GNAZ), mRNA. 1068 GC-A6359
PSEN1 NM_000021.4 Human Homo sapiens presenilin 1 (PSEN1), transcript variant 1, mRNA. 1404 GC-Z0049
ADRB3 NM_000025.3 Human Homo sapiens adrenoceptor beta 3 (ADRB3), mRNA. 1227 GC-U1168
CA2 NM_000067.3 Human Homo sapiens carbonic anhydrase 2 (CA2), transcript variant 1, mRNA. 783 GC-I0305
CHRNA1 NM_000079.4 Human Homo sapiens cholinergic receptor nicotinic alpha 1 subunit (CHRNA1), transcript variant 2, mRNA. 1374 GC-Z5856
CHRNE NM_000080.4 Human Homo sapiens cholinergic receptor nicotinic epsilon subunit (CHRNE), mRNA. 1482 GC-Z5712
CLCN5 NM_000084.5 Human Homo sapiens chloride voltage-gated channel 5 (CLCN5), transcript variant 3, mRNA. 2241 GC-M0936
CLN3 NM_000086.2 Human Homo sapiens CLN3, battenin (CLN3), transcript variant 2, mRNA. 1317 GC-Q0362
TOR1A NM_000113.3 Human Homo sapiens torsin family 1 member A (TOR1A), mRNA. 999 GC-M0262
EXT1 NM_000127.3 Human Homo sapiens exostosin glycosyltransferase 1 (EXT1), mRNA. 2241 GC-U0058
FGFR2 NM_000141.5 Human Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1, mRNA. 2466 GC-A0979
GJA1 NM_000165.5 Human Homo sapiens gap junction protein alpha 1 (GJA1), mRNA. 1149 GC-A0334
GK NM_000167.6 Human Homo sapiens glycerol kinase (GK), transcript variant 2, mRNA. 1575 GC-I0315
GLRA1 NM_000171.4 Human Homo sapiens glycine receptor alpha 1 (GLRA1), transcript variant 2, mRNA. 1350 GC-Z5742
GNAT1 NM_000172.4 Human Homo sapiens G protein subunit alpha transducin 1 (GNAT1), transcript variant 2, mRNA. 1053 GC-F0408
NR3C1 NM_000176.3 Human Homo sapiens nuclear receptor subfamily 3 group C member 1 (NR3C1), transcript variant 1, mRNA. 2334 GC-Z2515
HK1 NM_000188.3 Human Homo sapiens hexokinase 1 (HK1), transcript variant 1, mRNA. 2754 GC-T0174
ITGB3 NM_000212.3 Human Homo sapiens integrin subunit beta 3 (ITGB3), mRNA. 2367 GC-E2219
ITGB4 NM_000213.5 Human Homo sapiens integrin subunit beta 4 (ITGB4), transcript variant 1, mRNA. 5469 GC-Z3028
KCNA1 NM_000217.3 Human Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1), mRNA. 1488 GC-A4169
MAOA NM_000240.4 Human Homo sapiens monoamine oxidase A (MAOA), transcript variant 1, mRNA. 1584 GC-A0833
PTCH1 NM_000264.5 Human Homo sapiens patched 1 (PTCH1), transcript variant 1b, mRNA. 4344 GC-T0559
NME1 NM_000269.3 Human Homo sapiens NME/NM23 nucleoside diphosphate kinase 1 (NME1), transcript variant 2, mRNA. 459 GC-M0930
PGK1 NM_000291.4 Human Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA. 1254 GC-C0528
PPT1 NM_000310.4 Human Homo sapiens palmitoyl-protein thioesterase 1 (PPT1), transcript variant 1, mRNA. 921 GC-C0429
PTEN NM_000314.8 Human Homo sapiens phosphatase and tensin homolog (PTEN), transcript variant 1, mRNA. 1212 GC-I0450
QDPR NM_000320.3 Human Homo sapiens quinoid dihydropteridine reductase (QDPR), transcript variant 1, mRNA. 735 GC-C0150
SLC4A1 NM_000342.4 Human Homo sapiens solute carrier family 4 member 1 (Diego blood group) (SLC4A1), mRNA. 2736 GC-E0249
ABCC8 NM_000352.6 Human Homo sapiens ATP binding cassette subfamily C member 8 (ABCC8), transcript variant 2, mRNA. 4746 GC-Y4894