Phosphatases

Introduction

Phosphatases, which have the opposite function of protein kinases, remove phosphate groups from phosphorylated proteins by hydrolyzing the phosphate monoester into a phosphate group and a molecule with a free hydroxyl group. Dephosphorylation also occurs primarily on serine, threonine, and tyrosine residues. Members of the phosphoprotein phosphatases (PPPs) family include the PP1, PP2A, PP2B, PP4, PP5, PP6, and PP7 proteins, whose catalytic subunits are mostly combined with various regulatory subunits.
In contrast, members of the metal-dependent protein phosphatases (PPMs) family, represented by PP2C proteins, do not have regulatory subunits and are dependent on metal ions such as Mn2+ or Mg2+ for their catalytic processes. Abnormalities in protein phosphorylation have been implicated in the development of a wide variety of diseases, ranging from cancer to inflammatory diseases, diabetes, infectious diseases, and cardiovascular diseases.

Clone set information

Cat. No. Old Cat. No. Species Gene Vector Vector Type Price
OC-GF016-M02 OC-HPH-M02 Human 288 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF016-M35 OC-HPH-M35 Human 288 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF016-M98 OC-HPH-M98 Human 288 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF016-Lv105 OC-HPH-Lv105 Human 288 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF016-Lv242 OC-HPH-Lv242 Human 288 pReceiver-Lv242 Expression-ready Lentiviral Inquire
OC-GF016-GC OC-HPH-GC Human 288 pDONR™ Vector Gateway shuttle Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
CTDNEP1 NM_001143775.2 Human Homo sapiens CTD nuclear envelope phosphatase 1 (CTDNEP1), transcript variant 2, mRNA. 735 GC-Z6793
INPP4B NM_001101669.3 Human Homo sapiens inositol polyphosphate-4-phosphatase type II B (INPP4B), transcript variant 2, mRNA. 2775 GC-H3518
PDP1 NM_018444.4 Human Homo sapiens pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 5, mRNA. 1614 GC-I5460
G6PC1 NM_000151.4 Human Homo sapiens glucose-6-phosphatase catalytic subunit 1 (G6PC1), transcript variant 1, mRNA. 1074 GC-C0592
MTM1 NM_000252.3 Human Homo sapiens myotubularin 1 (MTM1), mRNA. 1812 GC-A4403
OCRL NM_000276.4 Human Homo sapiens OCRL inositol polyphosphate-5-phosphatase (OCRL), transcript variant a, mRNA. 2706 GC-Y3314
OCRL NM_000276.4 Human Homo sapiens OCRL inositol polyphosphate-5-phosphatase (OCRL), transcript variant a, mRNA. 2706 GC-Y3314
PON2 NM_000305.3 Human Homo sapiens paraoxonase 2 (PON2), transcript variant 1, mRNA. 1065 GC-Z9331
PTEN NM_000314.8 Human Homo sapiens phosphatase and tensin homolog (PTEN), transcript variant 1, mRNA. 1212 GC-I0450
PON1 NM_000446.7 Human Homo sapiens paraoxonase 1 (PON1), mRNA. 1068 GC-T3439
ALPL NM_000478.5 Human Homo sapiens alkaline phosphatase, liver/bone/kidney (ALPL), transcript variant 1, mRNA. 1575 GC-C0757
FBP1 NM_000507.4 Human Homo sapiens fructose-bisphosphatase 1 (FBP1), transcript variant 1, mRNA. 1017 GC-Z5880
FBP1 NM_000507.4 Human Homo sapiens fructose-bisphosphatase 1 (FBP1), transcript variant 1, mRNA. 1017 GC-Z5880
PPP3CA NM_000944.5 Human Homo sapiens protein phosphatase 3 catalytic subunit alpha (PPP3CA), transcript variant 1, mRNA. 1566 GC-M0372
PPP3R1 NM_000945.4 Human Homo sapiens protein phosphatase 3 regulatory subunit B, alpha (PPP3R1), mRNA. 513 GC-A0250
DUSP29 NM_001003892.3 Human Homo sapiens dual specificity phosphatase 29 (DUSP29), transcript variant 1, mRNA. 663 GC-Y3348
PHOSPHO2 NM_001008489.4 Human Homo sapiens phosphatase, orphan 2 (PHOSPHO2), transcript variant 2, mRNA. 726 GC-T2452
PPP1CA NM_001008709.2 Human Homo sapiens protein phosphatase 1 catalytic subunit alpha (PPP1CA), transcript variant 3, mRNA. 1026 GC-Z2528
PPP2CB NM_001009552.2 Human Homo sapiens protein phosphatase 2 catalytic subunit beta (PPP2CB), mRNA. 930 GC-C0307
PFKFB2 NM_001018053.2 Human Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), transcript variant 2, mRNA. 1416 GC-E0022
PON2 NM_001018161.2 Human Homo sapiens paraoxonase 2 (PON2), transcript variant 2, mRNA. 1029 GC-Z4142
DUSP28 NM_001033575.1 Human Homo sapiens dual specificity phosphatase 28 (DUSP28), mRNA. 531 GC-T9431
SIRPA NM_001040022.1 Human Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 1, mRNA. 1515 GC-Z2662
MTMR12 NM_001040446.3 Human Homo sapiens myotubularin related protein 12 (MTMR12), transcript variant 1, mRNA. 2244 GC-A1546
PTPN20 NM_001042364.5 Human Homo sapiens protein tyrosine phosphatase non-receptor type 20 (PTPN20), transcript variant 9, mRNA. 438 GC-I0735
PGP NM_001042371.3 Human Homo sapiens phosphoglycolate phosphatase (PGP), mRNA. 966 GC-H1100
PPP4R1 NM_001042388.3 Human Homo sapiens protein phosphatase 4 regulatory subunit 1 (PPP4R1), transcript variant 1, mRNA. 2853 GC-H1584
RHOC NM_001042679.2 Human Homo sapiens ras homolog family member C (RHOC), transcript variant 3, mRNA. 582 GC-I0317
CDC14B NM_001077181.3 Human Homo sapiens cell division cycle 14B (CDC14B), transcript variant 3, mRNA. 1386 GC-Z4276
MTMR14 NM_001077526.3 Human Homo sapiens myotubularin related protein 14 (MTMR14), transcript variant 1, mRNA. 1797 GC-T8732
ACP3 NM_001099.5 Human Homo sapiens acid phosphatase 3 (ACP3), transcript variant 1, mRNA. 1161 GC-I2323
PTPRM NM_001105244.2 Human Homo sapiens protein tyrosine phosphatase receptor type M (PTPRM), transcript variant 1, mRNA. 4398 GC-Z2922
ACYP1 NM_001107.5 Human Homo sapiens acylphosphatase 1 (ACYP1), transcript variant 1, mRNA. 300 GC-T7694
SET NM_001122821.2 Human Homo sapiens SET nuclear proto-oncogene (SET), transcript variant 1, mRNA. 873 GC-Z5816
PPM1M NM_001122870.3 Human Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1M (PPM1M), transcript variant 2, mRNA. 744 GC-T4082
PPP6C NM_001123355.2 Human Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 1, mRNA. 1029 GC-Z6272
PPP3CA NM_001130691.2 Human Homo sapiens protein phosphatase 3 catalytic subunit alpha (PPP3CA), transcript variant 2, mRNA. 1536 GC-Z0485
STYX NM_001130701.2 Human Homo sapiens serine/threonine/tyrosine interacting protein (STYX), transcript variant 2, mRNA. 672 GC-T4040
CDKN3 NM_001130851.2 Human Homo sapiens cyclin dependent kinase inhibitor 3 (CDKN3), transcript variant 2, mRNA. 519 GC-Z0967
PPIP5K1 NM_001130858.4 Human Homo sapiens diphosphoinositol pentakisphosphate kinase 1 (PPIP5K1), transcript variant 5, mRNA. 4302 GC-H3770
PPIP5K1 NM_001130858.4 Human Homo sapiens diphosphoinositol pentakisphosphate kinase 1 (PPIP5K1), transcript variant 5, mRNA. 4302 GC-H3770
PPIP5K1 NM_001130859.3 Human Homo sapiens diphosphoinositol pentakisphosphate kinase 1 (PPIP5K1), transcript variant 6, mRNA. 4227 GC-H1884
PPIP5K1 NM_001130859.3 Human Homo sapiens diphosphoinositol pentakisphosphate kinase 1 (PPIP5K1), transcript variant 6, mRNA. 4227 GC-H1884
ACP3 NM_001134194.2 Human Homo sapiens acid phosphatase 3 (ACP3), transcript variant 2, mRNA. 1257 GC-H3799
ACP3 NM_001134194.2 Human Homo sapiens acid phosphatase 3 (ACP3), transcript variant 2, mRNA. 1257 GC-H3799
INPP5K NM_001135642.2 Human Homo sapiens inositol polyphosphate-5-phosphatase K (INPP5K), transcript variant 3, mRNA. 1119 GC-Z3371
PTPRK NM_001135648.3 Human Homo sapiens protein tyrosine phosphatase receptor type K (PTPRK), transcript variant 1, mRNA. 4341 GC-Z6560
DUSP19 NM_001142314.2 Human Homo sapiens dual specificity phosphatase 19 (DUSP19), transcript variant 2, mRNA. 501 GC-H3970
PPP3CB NM_001142353.3 Human Homo sapiens protein phosphatase 3 catalytic subunit beta (PPP3CB), transcript variant 1, mRNA. 1578 GC-Z1028
PTPN18 NM_001142370.2 Human Homo sapiens protein tyrosine phosphatase non-receptor type 18 (PTPN18), transcript variant 2, mRNA. 1062 GC-Z6684