All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

Histone modification enzymes

Introduction

Histone modification refers to the dynamic process by which histones are modified through methylation, acetylation, phosphorylation, adenylation, ubiquitination, ADP-ribosylation and other processes which are facilitated by specific enzymes.

Histone modifying enzymes include: histone acetyltransferase HAT and histone deacetylase HDAC for controlling acetylation; histone methyltransferases HMTs/KMTs, protein arginine methyltransferases PRMTs, and lysine demethylases KDMs for methylation; ubiquitylating histone ubiquitin ligases and deubiquitylating enzymes, etc. Histone modifications are one of the major forms of epigenetics and play an important role in the regulation of genetic expression and phenotype. For example, histone modifications regulate the expression of nervous system-associated genes, which are involved in the normal function of the nervous system, adaptive regulation, and neurodegenerative diseases, with different roles depending on the type of histone modification.

Clone set information

Cat. No.	Old Cat. No.	Species	Gene	Vector	Vector Type	Price
OC-GF009-M02	OC-HHM-M02	Human	107	pReceiver-M02	Expression-ready Non-viral	Inquire
OC-GF009-M35	OC-HHM-M35	Human	107	pReceiver-M35	Expression-ready Non-viral	Inquire
OC-GF009-M98	OC-HHM-M98	Human	107	pReceiver-M98	Expression-ready Non-viral	Inquire
OC-GF009-Lv105	OC-HHM-Lv105	Human	107	pReceiver-Lv105	Expression-ready Lentiviral	Inquire
OC-GF009-Lv242	OC-HHM-Lv242	Human	107	pReceiver-Lv242	Expression-ready Lentiviral	Inquire
OC-GF009-GC	OC-HHM-GC	Human	107	pDONR™ Vector	Gateway shuttle	Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.

Symbol	Accession	Species	Description	ORF length(bp)	Product ID
HDAC9	NM_014707.4	Human	Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 3, mRNA.	1773	GC-E0013
DOT1L	NM_032482.3	Human	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA.	4614	GC-E0567
HDAC1	NM_004964.3	Human	Homo sapiens histone deacetylase 1 (HDAC1), mRNA.	1449	GC-I0488
KAT7	NM_007067.4	Human	Homo sapiens lysine acetyltransferase 7 (KAT7), transcript variant 1, mRNA.	1836	GC-T0265
HDAC3	NM_003883.4	Human	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA.	1287	GC-T1848
SIRT2	NM_012237.4	Human	Homo sapiens sirtuin 2 (SIRT2), transcript variant 1, mRNA.	1170	GC-T1930
HDAC11	NM_024827.4	Human	Homo sapiens histone deacetylase 11 (HDAC11), transcript variant 1, mRNA.	1044	GC-T2114
SETD7	NM_030648.4	Human	Homo sapiens SET domain containing 7, histone lysine methyltransferase (SETD7), transcript variant 1, mRNA.	1101	GC-T3450
HDAC10	NM_032019.6	Human	Homo sapiens histone deacetylase 10 (HDAC10), transcript variant 1, mRNA.	2010	GC-T3601
SUV39H1	NM_003173.4	Human	Homo sapiens SUV39H1 histone lysine methyltransferase (SUV39H1), transcript variant 2, mRNA.	1239	GC-U1202
HDAC4	NM_006037.4	Human	Homo sapiens histone deacetylase 4 (HDAC4), transcript variant 2, mRNA.	3255	GC-U1371
HDAC6	NM_001321230.2	Human	Homo sapiens histone deacetylase 6 (HDAC6), transcript variant 7, mRNA.	441	GC-V0819
HDAC7	NM_001098416.4	Human	Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 4, mRNA.	2865	GC-Z1602
HDAC5	NM_001015053.2	Human	Homo sapiens histone deacetylase 5 (HDAC5), transcript variant 3, mRNA.	3372	GC-Z4127
HDAC7	NM_015401.5	Human	Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 1, mRNA.	2976	GC-Z4621
HDAC9	NM_058176.2	Human	Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 1, mRNA.	3036	GC-E2449
HDAC9	NM_178425.4	Human	Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 5, mRNA.	3210	GC-E2498
SIRT2	NM_030593.3	Human	Homo sapiens sirtuin 2 (SIRT2), transcript variant 2, mRNA.	1059	GC-T3000
EDF1	NM_003792.4	Human	Homo sapiens endothelial differentiation related factor 1 (EDF1), transcript variant alpha, mRNA.	447	GC-U0296
ELP3	NM_018091.6	Human	Homo sapiens elongator acetyltransferase complex subunit 3 (ELP3), transcript variant 1, mRNA.	1644	GC-V0251
OGA	NM_012215.5	Human	Homo sapiens O-GlcNAcase (OGA), transcript variant 1, mRNA.	2751	GC-U1247
CDY1	NM_170723.2	Human	Homo sapiens chromodomain Y-linked 1 (CDY1), transcript variant 1, mRNA.	1623	GC-Z4039
CDYL	NM_004824.4	Human	Homo sapiens chromodomain Y like (CDYL), transcript variant 1, mRNA.	1635	GC-Z1307
CLOCK	NM_001267843.2	Human	Homo sapiens clock circadian regulator (CLOCK), transcript variant 1, mRNA.	2541	GC-U0240
ELP4	NM_019040.5	Human	Homo sapiens elongator acetyltransferase complex subunit 4 (ELP4), transcript variant 1, mRNA.	1275	GC-T1173
GTF3C4	NM_012204.4	Human	Homo sapiens general transcription factor IIIC subunit 4 (GTF3C4), transcript variant 1, mRNA.	2469	GC-U0508
NCOA3	NM_006534.4	Human	Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 2, mRNA.	4263	GC-Z3016
NCOA3	NM_181659.3	Human	Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 1, mRNA.	4275	GC-Z5301
USP22	NM_015276.2	Human	Homo sapiens ubiquitin specific peptidase 22 (USP22), mRNA.	1578	GC-H1929
MTA2	NM_004739.4	Human	Homo sapiens metastasis associated 1 family member 2 (MTA2), transcript variant 1, mRNA.	2007	GC-U1472
EZH1	NM_001991.5	Human	Homo sapiens enhancer of zeste 1 polycomb repressive complex 2 subunit (EZH1), transcript variant 1, mRNA.	2244	GC-M0269
EZH2	NM_004456.5	Human	Homo sapiens enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), transcript variant 1, mRNA.	2256	GC-Z0388
EZH2	NM_152998.3	Human	Homo sapiens enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), transcript variant 2, mRNA.	2124	GC-Z5167
PRDM7	NM_001098173.2	Human	Homo sapiens PR/SET domain 7 (PRDM7), mRNA.	1479	GC-H1723
KMT5B	NM_016028.4	Human	Homo sapiens lysine methyltransferase 5B (KMT5B), transcript variant 2, mRNA.	1182	GC-Z4641
KMT5B	NM_017635.5	Human	Homo sapiens lysine methyltransferase 5B (KMT5B), transcript variant 1, mRNA.	2658	GC-Z4681
KMT5C	NM_032701.4	Human	Homo sapiens lysine methyltransferase 5C (KMT5C), mRNA.	1389	GC-Z1256
NSD2	NM_133335.4	Human	Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 3, mRNA.	4098	GC-W0268
NSD2	NM_007331.2	Human	Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 8, mRNA.	1890	GC-X0368
NSD2	NM_133334.2	Human	Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 7, mRNA.	1944	GC-Z5057
NSD3	NM_023034.2	Human	Homo sapiens nuclear receptor binding SET domain protein 3 (NSD3), transcript variant long, mRNA.	4314	GC-V1657
NSD3	NM_017778.3	Human	Homo sapiens nuclear receptor binding SET domain protein 3 (NSD3), transcript variant short, mRNA.	1938	GC-X0597
JMJD6	NM_015167.3	Human	Homo sapiens jumonji domain containing 6, arginine demethylase and lysine hydroxylase (JMJD6), transcript variant 2, mRNA.	1212	GC-E2113
SUV39H2	NM_001193426.2	Human	Homo sapiens SUV39H2 histone lysine methyltransferase (SUV39H2), transcript variant 4, mRNA.	693	GC-T7836
PRMT5	NM_006109.5	Human	Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 1, mRNA.	1914	GC-V1247
KDM1A	NM_001009999.3	Human	Homo sapiens lysine demethylase 1A (KDM1A), transcript variant 1, mRNA.	2631	GC-E2594
KDM4C	NM_001146695.4	Human	Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 3, mRNA.	2442	GC-Z7106
KDM4C	NM_001146696.2	Human	Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 4, mRNA.	2508	GC-H4294
KDM4E	NM_001161630.1	Human	Homo sapiens lysine demethylase 4E (KDM4E), mRNA.	1521	GC-H4383
KDM5A	NM_001042603.3	Human	Homo sapiens lysine demethylase 5A (KDM5A), mRNA.	5073	GC-H3429