All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

CRISPR & TALEN Publications

View selected publications citing GeneCopoeia’s genome editing products and services from the recent literature

2025

Zhou, Y., et al. (2025). DRD4 Interacts with TGF‐β Receptors to Drive Colorectal Cancer Metastasis Independently of Dopamine Signaling Pathway. Adv Sci (Weinh) DOI: 10.1002/advs.202413953 [GeneHero™ sgRNA clones targeting human DRD4]

2024

Stearns, K., et al. (2024). Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry. mBio DOI: 10.1128/mbio.02327-24 [GeneHero™ CRISPRa Stable Cell Lines HEK293 stably expressing dCas9-VP64 and MPH complex, Cat. No. SL302]
Suganuma, T., et al. (2024). C G composition in transposon-derived genes is increased in FXD with perturbed immune system. NAR Mol Med DOI: 10.1093/narmme/ugae015 [GeneHero™ human Cas9 all-in-one expression clone targeting MOCS2, XDH and LOC84661, Cat. No. HCP211287-CG01-3, HCP218552-CG01-3, HCP220858-CG01-3]
Duron, D.I., et al. (2024). Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment. Sci Rep. DOI: 10.1038/s41598-024-65637-6 [sgRNA/Cas9 all-in-one expression clones targeting Hsp90α, Hsp90β and Grp94]
Zhou, Y., et al. (2024). GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma. Theranostics. DOI: 10.7150/thno.92646 [sgRNA/Cas9 all-in-one expression clone targeting GPAT3]
Yu, T., et al. (2024). NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation. Cell Rep. DOI: 10.1016/j.celrep.2024.114070 [Cas9 nuclease expression vector]
Roy, S.K., et al. (2024). Clinical significance of PNO1 as a novel biomarker and therapeutic target of hepatocellular carcinoma. J Cell Mol Med. DOI: 10.1111/jcmm.18295 [GeneHero™ Scrambled sgRNA control for pCRISPR-LvSG03; GeneHero™ 3×sgRNA lentiviral expression clone targeting PNO1; Cas9 nuclease lentiviral expression clones]
Jiang, Y., et al. (2024). Targeting the Cdc2‐like kinase 2 for overcoming platinum resistance in ovarian cancer. MedComm (2020). DOI: 10.1002/mco2.537 [OMICSLINK™ Human CLK2 ORF expression clone, Cat. No.EX-X0960-Lv121; GeneHero™ sgRNA clones targeting Human CLK2, Cat. No.HCP001098‐CG01‐3‐10]
Rupasinghe, M., et al. (2024). PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency. EMBO Rep. DOI: 10.1038/s44319-024-00083-z [GeneHero™ mouse ROSA26 safe harbor gene knock-in kit, Cat. No. SH054]
Xue Zhang, et al. 2024.Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity. Nat Commun.DOI:10.1038/s41467-024-44778-2[GeneHero™ CRISPR Products and Services (Cat. No.pCRISPR-CG01-sgBmal1-a; pCRISPR-CG01-sgBmal1-b;pCRISPR-CG01-sgBmal1-c;pCRISPR-CG01-scramble)]
Sherif Rashad, et al. 2024.Translational response to mitochondrial stresses is orchestrated by tRNA modifications. bioRxiv.DOI:10.1101/2024.02.14.580389[T7 endonuclease I assay kit]

2023

Helen R. Maunsell, et al. 2023.Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti. J Neurosci. DOI:10.1523/JNEUROSCI.2141-22.2023 [GeneHero™ TALEN Services]
Liu, W., et al. (2023). MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer. Cell Mol Biol Lett. doi: 10.1186/s11658-023-00487-0 [OMICSLINK™ Human MCCC2 ORF expression clone; GeneHero™ sgRNA clones targeting Human MCCC2]
Dorgham, M.G., et al. (2023). m6A regulates breast cancer proliferation and migration through stage-dependent changes in Epithelial to Mesenchymal Transition gene expression. Front Oncol. doi: 10.3389/fonc.2023.1268977 [GeneHero™ human Cas9 all-in-one expression clone targeting METTL3; GeneHero™ Scrambled sgRNA control for pCRISPR-CG01]
Xu, L., et al. (2023). Generation of Rh D‐negative blood using CRISPR/Cas9. Cell Prolif. doi: 10.1111/cpr.13486 [GeneHero™ Cas9 expressing vector; GeneHero™ AAVS1 Cas9 knock-in clone]
Itson-Zoske, B., et al. (2023). Selective RNAi-silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury. Res Sq. doi: 10.21203/rs.3.rs-3405016/v1 [GeneHero™ Cas9 expressing stable cell line]
Grzelak, C.A., et al. (2023). Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele. Immunohorizons. doi: 10.4049/immunohorizons.2200101 [Genome-TALER™ Mouse ROSA26 Safe Harbor ORF clone]
Liesenhoff, C., et al. (2023). Endogenous Galectin-1 Modulates Cell Biological Properties of Immortalized Retinal Pigment Epithelial Cells In Vitro. Int J Mol Sci. doi: 10.3390/ijms241612635 [GeneHero™ human Cas9 all-in-one expression clone targeting LGALS1]
Schuler, B., et al. (2023). Host Lipid Transport Protein ORP1 Is Necessary for Coxiella burnetii Growth and Vacuole Expansion in Macrophages. mSphere doi: 10.1128/msphere.00104-23 [GeneHero™ sgRNA expression clones targeting OSBPL1A]
Pal, D., et al. (2023). H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function. Nat Struct Mol Biol doi: 10.1038/s41594-023-01016-5 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit]
Naoki, I-T., et al. (2023). The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling. Cells doi: 10.3390/cells12131696 [GeneHero™ sgRNA clones targeting mouse Blk; GeneHero™ sgRNA clones targeting mouse Scr]
Talic, E-S., et al. (2023). RNA Methyltransferase METTL16’s Protein Domains Have Differential Functional Effects on Cell Processes. Curr Issues Mol Biol doi: 10.3390/cimb45070346 [GeneHero™ sgRNA control; GeneHero™ METTL16 Cas9-expressing clone]
Wan, Y., et al. (2023). Nonmonotone invasion landscape by noise-aware control of metastasis activator levels. Nat Chem Biol doi: 10.1038/s41589-023-01344-z [Genome-TALER™ human AAVS1 safe harbor gene knock-in kits and clones]
Schwarz, A.M., et al. Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A2A Receptors. bioRxiv doi: 10.1101/2023.03.28.534594 [GeneHero™ Cas9-expressing clone]
Li, C., et al. (2023). SUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation. J Proteome Res doi: 10.1021/acs.jproteome.2c00557 [GeneHero™ PIAS1、PIAS2、PIAS3、PIAS4 sgRNA clones and negative control]
Qin, Q., et al. (2023). CNTNAP4 signaling regulates osteosarcoma disease progression. NPJ Precis Oncol doi: 10.1038/s41698-022-00344-x [T7 Endonuclease I Assay Kit; SuperCut™ Nuclease]
Lin, P., et al. (2023). TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer. Cell Death Dis doi: 10.1038/s41419-022-05524-y [GeneHero™ Cas9-expressing clone]
Atobatele, A.G., et al. (2023). Canonical and truncated transglutaminase-2 regulate mucin-1 expression and androgen independency in prostate cancer cell lines. Cell Death Dis doi: 10.1038/s41419-023-05818-9 [GeneHero™ TGM2 sgRNA clones]

2022

Martin-Gallausiaux, C., et al. (2022). Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway. Gut Microbes doi: 10.1080/19490976.2022.2110639 [GeneHero™ sgRNA clones targeting TIFA、TRAF6 、 MYD88]
Liu, S., et al. (2022). DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells. J Biol Chem doi: 10.1016/j.jbc.2022.102770 [GeneHero™ RAD52/FANCJ sgRNA clones]
Ren, L., et al. (2022). Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight doi: 10.1172/jci.insight.162602 [GeneHero™ sgRNA clones targeting Adcy1]
Chupradit, K., et al. (2022). Validation of Promoters and Codon Optimization on CRISPR/Cas9-Engineered Jurkat Cells Stably Expressing αRep4E3 for Interfering with HIV-1 Replication. Int J Mol Sci doi: 10.3390/ijms232315049 [DC-DON-SH01 expression vector for restriction enzyme cloning]
Zhang, D.Y., et al. (2022). Whole Exome Sequencing Identifies PHF14 Mutations in Neurocytoma and Predicts Responsivity to the PDGFR Inhibitor Sunitinib. Biomedicines doi: 10.3390/biomedicines10112842 [sgRNA control]
Brooks, R., et al. (2022). Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Cell Rep doi: 10.1016/j.celrep.2022.111514 [BMAL1 gRNA]
Han, S.T., et al. (2022). PUS7 deficiency in human patients causes profound neurodevelopmental phenotype by dysregulating protein translation. Molecular Genetics and Metabolism doi: 10.1016/j.ymgme.2022.01.103 [GeneHero™ HeLa Cas9-expressing stable cell line]
Sánchez-Marco, J., et al. (2022). Thioredoxin Domain Containing 5 Suppression Elicits Serum Amyloid A-Containing High-Density Lipoproteins. Biomedicines doi: 10.3390/biomedicines10030709 [IndelCheck™ Insertion/deletion detection system]
Asuthkar, S., et al. (2022). SMYD3 Promotes Cell Cycle Progression by Inducing Cyclin D3 Transcription and Stabilizing the Cyclin D1 Protein in Medulloblastoma. Cancers doi: 10.3390/cancers14071673 [GeneHero™ SMYD3 sgRNA clones]
Zhang, L., et al. (2022). CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells. Molecular Cancer doi: 10.1186/s12943-022-01524-w [GeneHero™ sgRNA clones targeting CDK6]
Kaneski, C.R., et al. (2022). Generation of an in vitro model for peripheral neuropathy in Fabry disease using CRISPR-Cas9 in the nociceptive dorsal root ganglion cell line 50B11. Molecular Genetics and Metabolism Reports doI; 10.1016/j.ymgmr.2022.100871 [GeneHero™ sgRNA clones targeting GLA]
Wang, Y., et al. (2022). Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia. Cell Death & Disease doi: 10.1038/s41419-022-04873-y [IndelCheck™ Insertion/deletion detection system]
Badrinath, S., et al. (2022). A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature doi: 10.1038/s41586-022-04772-4 [Genome-TALER™ mouse ROSA26 safe harbor gene knockin kit and donor]
Domingo-Vidal. M., et al. (2022). Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers. Frontiers in Oncology doi: 10.3389/fonc.2022.906494 [GeneHero™ lentiviral sgRNA clones targeting SLC16A3]
Tontonoz, P. and Kaeberlein, P. (2022). SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B. eLife doi: 10.7554/eLife.67452 [GeneHero™ sgRNA clones targeting mSirt1]
Zheng, W., et al. (2022). SIRT1 inactivation switches reactive astrocytes to an anti-inflammatory phenotype in CNS autoimmunity. The Journal of Clinical Investigation doi: 10.1172/JCI151803 [GeneHero™ Neuro2a Cas9-expressing stable cell line]

2021

Simkin, D., et al. (2021). Dyshomeostatic modulation of Ca2+-activated K+channels in a humanneuronal model of KCNQ2 encephalopathy. wLife doi: 10.7554/eLife.64434 [IndelCheck™ Insertion/deletion detection system]
Hana, S., et al. (2021) Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice. Gene Therapy doi: 10.1038/s41434-021-00224-2 [GeneHero™ HeLa, Neuro2a Cas9-expressing stable cell lines]
Lee, Y., et al. (2021). Time-of-day specificity ofanticancer drugs may bemediated by circadian regulation ofthecell cycle. Science Advances doi: 10.1126/sciadv.abd2645 [GeneHero™ sgRNA clones]
Liu, S., et al. (2021). Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses. Nucleic Acids Research doi: 10.1093/nar/gkab120 [GeneHero™ HeLa Cas9-expressing stable cell line]
Li, X., et a. (2021). Enhancing Gene Editing Efficiency for Cells by CRISPR/Cas9 System-Loaded Multilayered Nanoparticles Assembled via Microfluidics. Chinese Journal of Chemical Engineering doi: 10.1016/j.cjche.2021.02.009 [GeneHero™ Cas9-expressing clone]
Kwik, M., et al. (2021). Selective Activation of CNS and ReferencePPARGC1APromoters Is Associated with Distinct Gene Programs Relevantfor Neurodegenerative Diseases. International Journal of Molecular Sciences doi: 10.3390/ijms22073296 [GeneHero™ sgRNA clones]
Huo, X., et al. (2021). MicroRNA-4325 Suppresses Cell Progression in Hepatocellular Carcinoma via GATA-Binding Protein 6. BioMed Research International doi: 10.1155/2021/6616982 [GeneHero™ sgRNA clones targeting GATA6]
Monserrat, J., et al. (2021). Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability. Nature Cell Biology doi: 10.1038/s41556-021-00657-2 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit]
Galula, J. C., et al. (2021). Comparable Accuracies of Nonstructural Protein 1- and EnvelopeProtein-Based Enzyme-Linked Immunosorbent Assays inDetecting Anti-Dengue Immunoglobulin G Antibodies. Diagnostics doi: 10.3390/diagnostics11050741 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit] (2021). Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons. Translational Psychiatry doi: 10.1038/s41398-021-01392-w [GeneHero™ donor clone]
Kronenberg, J., et al. (2021). The tobacco phosphatidylethanolamine-binding protein NtFT4 simultaneously improves vitality, growth and protein yield in human cells. Biotechnology and Bioengineering doi: 10.1002/bit.27853 [GenomeTALER™ human AAVS1 safe harbor gene knockin kit]
Woo, H-H. and Chambers, S.K. (2021). Regulation of closely juxtaposed protooncogene c-fms and HMGXB3 gene expression by mRNA 3’end polymorphism in breast cancer cells. RNA doi: 10.1261/rna.078749.121 [GeneHero™ donor clone]
Gozgit, J.M., et al. (2021). PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Cancer Cell doi: 10.1016/j.ccell.2021.06.018 [GeneHero™ CT26 Cas9-expressing stable cell line]
Pons, B.J., et al. (2021). Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response. Cellular and Molecular Life Sciences doi: 10.1007/s00018-021-03902-x [GenomeTALER™ human AAVS1 safe harbor gene knockin kit]
Pe~na-Hernandez, P., et al. (2021). BAZ2A-mediated repression via H3K14ac-markedenhancers promotes prostate cancer stem cells. EMBO Reports doi: 10.15252/embr.202153014 [GenomeCRISPR™ mouse ROSA26 BAZ2A safe harbor gene knockin clone]
Chafe, S.C., et a. (2021). Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. Science Advances doi: 10.1126/sciadv.abj0364 [GeneHero™ sgRNA clones]
Xia, L., et al. (2021). Multiplatform discovery and regulatory function analysis of structural variations in non-small cell lung carcinoma. Cell Reports doi: 10.1016/j.celrep.2021.109660 [GeneHero™ sgRNA and HDR donor clones]
Dzakah, E.E., et al. (2021). Chlamydia trachomatis stimulation enhances HIV-1 susceptibility via the modulation of a member of the macrophage inflammatory proteins. Journal of Investigative Dermatology doi: 10.1016/j.jid.2021.09.020 [GeneHero™ lentiviral sgRNA clones]
López-Royo, T., et al, (2021). Encapsulation of Large-Size Plasmids in PLGA Nanoparticles for Gene Editing: Comparison of Three Different Synthesis Methods. Nanomaterials 10.3390/nano11102723 [GenomeCRISPR™ safe harbor gene knockin clone]
Stojkovska, I., et al. (2021). Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking. Neuron doi: 10.1016/j.neuron.2021.10.032 [IndelCheck™ Insertion/deletion detection system]
Song, Y., et al. (2021). A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis. PLOS Pathogens doi: 10.1371/journal.ppat.1010141 [GeneHero™ A549 Cas9-expressing stable cell line]
Szaflarski, W. , et al. (2021). Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity. Nucleic Acids Research doi: 10.1093/nar/gkab1231 [GeneHero™ sgRNA and HDR donor clones]

2020

Frendewey, D., et al. (2020). METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAS. United States Patent Application 20200002730 [GeneHero™ sgRNA clones targeting Lrp5]
Zhang, L., et al. (2020). The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer. Molecular Cancer doi: 10.1186/s12943-019-1112-1 [GeneHero™ sgRNA clones targeting PIK3CA, PIK3CB]
Chen, P., et al. (2020). High RhCG expression predicts poor survival and promotes migration and proliferation of gastric cancer via keeping intracellular alkaline. Experimental Cell Research doi: 10.1016/j.yexcr.2019.111740 [GeneHero™ sgRNA clone]
López, S.M., et al. (2020). Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy. PLOS ONE doi: 10.1371/journal.pone.0228072 [GeneHero™ sgRNA clones, GenomeTALER™ TALEN clones, and donor clone targeting canine DMD]
Joshi, A., et al. (2020). The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biology doi: 10.1186/s12915-020-0740-7 [GeneHero™ sgRNA clones targeting UMUC3]
Li, C., et al. (2020). Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility, Nature Communications doi: 10.1038/s41467-020-14581-w [GeneHero™ sgRNA clones targeting PIAS]
Phu, L., et al. (2020). Dynamic Regulation of Mitochondrial Import by the Ubiquitin System. Molecular Cell doi: 10.1016/j.molcel.2020.02.012 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit]
Stinger, R.N., et al. (2020). A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity. Molecular Brain doi: 10.1186/s13041-020-00577-6 [GeneHero™ sgRNA clones and donor clone]
Rakvács, Z. (2020). Investigation of the human ABCB6 transporter. Ph.D. Thesis, Semmelweis University [IndelCheck™ Insertion/deletion detection system]
Renema, P., et al. (2020). cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. American Journal of Physiology-Lung Cellular and Molecular Physiology doi: 10.1152/ajplung.00185.2019 [GeneHero™ sgRNA clones targeting Rat Casp1]
Lin, C-L., et al. (2020). ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer. BMC Medical Genomics doi: 10.1186/s12920-020-0729-7 [GeneHero™ sgRNA clones]
Meinhardt, G., et al. (2020). Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta . Proceedings of the National Academy of Scienes of the United States of America doi: 10.1073/pnas.2002630117 [GeneHero™ sgRNA clones targeting YAP]
Nelson, J., et al. (2020). Impact of mRNA chemistry and manufacturing process on innate immune activation. Science Advances doi: 10.1126/sciadv.aaz6893 [GeneHero™ sgRNA clones targeting MAVS]
Schweitzer, K.S., et al. (2020). IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI insight doi: 10.1172/jci.insight.138101 [GeneHero™ sgRNA clones targeting Beas2B]
Badaoui, M., et al. (2020). Vav3 Mediates Pseudomonas aeruginosa Adhesion to the Cystic Fibrosis Airway Epithelium. Cell Reports doi: 10.1016/j.celrep.2020.107842 [GeneHero™ leniviral particles expressing sgRNA clones targeting Vav3]
Renema, P., et al. (2020). cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. American Journal of Physiology – Lung Cellular and Molecular Physiology doi: 10.1152/ajplung.00185.2019 [GeneHero™ sgRNA clones targeting caspase-1]
Feng, Y.C., et al. (2020). c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Nature Communications doi: 10.1038/s41467-020-18735-8 [GeneHero™ CRISPRi sgRNA clones targeting MILIP]
Wang, L., et al. (2020). Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. The ournal of Clinical Investigation doi: 10.1172/JCI130445 [GeneHero™ sgRNA clones targeting Arid1a]
Chaudhari, H.G., et al. (2020). Evaluation of Homology-Independent CRISPR-Cas9Off-Target Assessment Methods. The CRISPR Journal doi: 10.1089/crispr.2020.0053 [GeneHero™ HEK293 Cas9-expressing stable cell line]
Morleo, M., et al. (2020). Regulation of autophagosome biogenesis byOFD1-mediated selective autophagy. The EMBO Journal doi: 10.15252/embj.2020105120 [GeneHero™ sgRNA clones]

2019

Gürtler, S., et al. (2019). Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids doi: 10.1016/j.bbalip.2019.01.006 [GeneHero™ sgRNA clones targeting Taz1]
Wang, Z., et al. (2019). DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. The Journal of Biological Chemistry doi: 10.1074/jbc.RA118.005188 [GeneHero™ sgRNA clones targeting POLQ]
Adams, J., et al. (2019). Autophagy–lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease. Scientific Reports doi: 10.1038/s41598-018-36379-z [GeneHero™ sgRNA clones targeting SNCA]
Geng, Y., et al. (2019). PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis. JCI Insight [GeneHero™ sgRNA clone targeting CD274]
Zheng, Y-L., et al. (2019). LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway. Theranostics doi: 10.7150/thno.28992 [GeneHero™ sgRNA clones targeting LINC01554]
Pushpavathi, G., et al. (2019). CRISPR/Cas9 Editing of Glia Maturation Factor Regulates Mitochondrial Dynamics by Attenuation of the NRF2/HO-1 Dependent Ferritin Activation in Glial Cells. Journal of Neuroimmune Pharmacology doi: 10.1007/s11481-019-09833-6 [GeneHero™ lentiviral sgRNA clones]
Zang, J., et al. (2019). Glucose drives growth factor-independent esophageal cancer proliferation viaphosphohistidine-FAK signaling. Cellular and Molecular Gastroenterology and Hepatology doi:10.1016/j.jcmgh.2019.02.009 [GeneHero™ sgRNA clones targeting PTK2]
Zhang, D., et al. (2019). Chromogranin A regulates neuroblastoma proliferation and phenotype. Biology Open doi: 10.1242/bio.036566 [GeneHero™ sgRNA clones targeting CHGA]
Ji, J., et al. (2019). FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX. Oxidative Medicine and Cellular Longevity doi: 10.1155/2019/3286928 [GeneHero™ sgRNA clones targeting FOXO1; IndelCheck™ Insertion/deletion detection system]
Pradhan, A.K., et al. (2019). MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF. Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1819869116 [GeneHero™ sgRNA clones targeting MDA-7/IL-24]
Iyer, K.S., et al. (2019). BIOCOMPATIBLE DENDRONISED POLYMER AS A NON – VIRAL TRANSFECTION AGENT. United States Patent Application 16/128,936 [Genome-TALER™ TALE-TF clone]
Ghoshal, A., et al. (2019). Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis. Oncogene doi: 10.1038/s41388-019-0797-3 [GeneHero™ sgRNA clones targeting IGF2BP1]
Pan, C., et al. (2019). Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. Journal of Clinical INvestigation doi: 10.1172/JCI124550DS1 [GeneHero™ lentiviral sgRNA clones targeting IGF2BP1]
Ramakrishnan, A. (2019). DISC1 is needed for the organization of cellular components at the immunological synapse. Ph.D. Thesis, University of Texas [GeneHero™ lentiviral sgRNA clones targeting DISC1]
Sastri, M. (2019). PEPTIDES FOR ANGIOGENIC THERAPY. United States Patent Application 20190389922 [Genome-TALER™ Human AAVS1 Safe Harbor knock-in kit]
Wall, C.E., et al. (2019). PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin. Cell Reports doi: 10.1016/j.celrep.2019.10.130 [GeneHero™ sgRNA clones targeting PPEF2]
Narimani, M., et al. (2019). Knockout Of BIRC5 Gene By CRISPR/Cas9 Induces Apoptosis And Inhibits Cell Proliferation In Leukemic Cell Lines, HL60 And KG1/. Blood and Lymphatic Cancer: Targets and Therapy doi: 10.2147/BLCTT.S230383 [GeneHero™ sgRNA clones]
Masoudi, M., et al. (2010). A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine. Scientific Reports doi: 10.1038/s41598-019-55893-2 [IndelCheck™ Insertion or Deletion Detection System]
Kang, K., et al. (2019). An improved Tet-on system in microRNA overexpression and CRISPR/Cas9-mediated gene editing. Journal of Animal Science and Biotechnology doi: 10.1186/s40104-019-0354-5 [T7 Endonuclease I]
Turturro, S.B., et al. (2019). Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway. Breast Cancer Research and Treatment doi: 10.1007/s10549-019-05320-x [GeneHero™ sgRNA clones]
Sussman, W., et al. (2019). BMAL1 controls glucose uptake through paired-homeodomain transcriptionfactor 4 in differentiated Caco-2 cells. American Journal of Physiology-Cell physiology doi: 10.1152/ajpcell.00058.2019 [GeneHero™ sgRNA clones targeting PAX4]
Kulbay, M., et al. (2019). DNA fragmentation factor 40 expression in T cells confers sensibility to tributyltin-induced apoptosis. Toxicology doi: 10.1016/j.tox.2019.152255 [GeneHero™ sgRNA clones]
Li, H., et al. (2019). PFN2a Suppresses C2C12 Myogenic Development by Inhibiting Proliferation and Promoting Apoptosis via the p53 Pathway. Cells doi: 10.3390/cells8090959 [GeneHero™ mouse ROSA26 safe harbor gene knockin kit]
Barrow, M.A., et a. (2019). A functional role for the cancer disparity-linked genes, CRYβB2 and CRYβB2P1, in the promotion of breast cancer. Breast Cancer Research doi: 10.1186/s13058-019-1191-3 [GeneHero™ sgRNA clones]
Kuo, T., et al. (2019). Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion. Proceedingsof the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1904311116 [GeneHero™ sgRNA clones targeting C2CD4A]
Fujimoto, B.A., et al. (2019). The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells. American Journal of Physiology-Enocrinology and Metabolism doi: 0.1152/ajpendo.00109.2019 [GeneHero™ sgRNA clones]
Yu, W., et al. (2019). Higher expression of SATB2 in hepatocellular carcinoma of African Americans determines more aggressive phenotypes than those of Caucasian Americans. Journal of Cellular and Molecular Medicine doi: 10.1111/jcmm.14652 [GeneHero™ lentiviral CRISPR clones targeting SATB2]
Gohari, I.M., et al. (2019). Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells. Toxins doi: 10.3390/toxins11100582 [GeneHero™ CRISPR clones targeting Claudin-1]

2018

Kanda, Y., et al. (2018). TRPA1-dependent reversible opening of tight junction by natural compounds with an α,β-unsaturated moiety and capsaicin. Scientific Reports doi: 10.1038/s41598-018-20526-7 [Genome-CRISP™ sgRNA clones targeting TRPA1]
Chen, X., et al. (2018). A spliced form of CD44 expresses the unique glycan that is recognized by the prostate cancer specific antibody F77. Ocotarget doi: 10.18632/oncotarget.23341 [Genome-CRISP™ CRISPR-Cas9 constructs]
Maier, M., et al. (2018). The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. International Journal of Molecular Sciences doi: 10.3390/ijms19020479 [Genome-CRISP™ lentiviral clone expressing sgRNA targeting Trio]
Sokhi, U.K., et al. (2018). Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models. Nature Communications doi: 10.1038/s41467-018-03081-7 [HEK293T Cas9-expressing stable cell line]
Zhao, D., et al. (2018). Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Molecular Cell doi: 10.1016/j.molcel.2018.01.017 [HeLa, HEK293T and A549 Cas9-expressing stable cell lines]
Norouzi-Barough, L., et al. (2018). Bioinformatics design of CRISPR guide RNA for genomic knockout of ABCB1 gene. Biotech Health Sci . 2018 Feb; 4(3):e58783[Genome-CRISP™ clones expressing sgRNA targeting ABCB1]
Quadalti, C., et al. (2018). SURF1 knockout cloned pigs: Early onset of a severe lethal phenotype. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease doi: 10.1016/j.bbadis.2018.03.021 [Genome-TALER™ clone targeted to SURF1]
Raikwar, S.P., et al. (2018). Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer’s Disease Therapeutic Target. Molecular Neurobiology doi: 10.1007/s12035-018-1068-y [Genome-CRISP™ lentiviral clones expressing sgRNA targeting GMF]
Shen, J., et al. (2018). ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nature Medicine doi: 10.1038/s41591-018-0012-z [Genome-CRISP™ lentiviral clones expressing sgRNA targeting ARID1A]
Huang, H., et al. (2018). EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Molecular Cell doi: 10.1016/j.molcel.2018.04.011 [Genome-CRISP™ clones expressing sgRNA targeting EP300]
Bezawork-Geleta, A., et al. (2018). Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nature Communications doi: 10.1038/s41467-018-04603-z [Genome-TALER™ clone targeted to SDHB]
Dakhama, A. and Chu, H-W. (2018). The Use of CRISPR-Cas9 Technology to Reveal Important Aspects of Human Airway Biology. Type 2 Immunity doi: 10.1007/978-1-4939-7896-0_27 [Lentiviral CRISPR clones]
Li, Y., et al. (2018). Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage, Nucleic Acids Research doi: 10.1093/nar/gky568 [Lentiviral CRISPR clones]
Sharlati, L., et al. (2018). Disruption of SOX6 gene using CRISPR/Cas9 technology for gamma‐globin reactivation: An approach towards gene therapy of β‐thalassemia. Journal of Cellular Biochemistry doi: 10.1002/jcb.27253 [CRISPR clones]
Suganuma, T., et al. (2018). MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism. Cell Reports doi: 10.1016/j.celrep.2018.07.013 [Genome-CRISP™ clone expressing sgRNA targeting MOCS2]
Hulea, L., et al. (2018). Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Cell Metabolism doi: 10.1016/j.cmet.2018.09.001 [GeneHero™ clones expressing sgRNAs targeting h4E-BP1, h4E-BP2, m4E-BP1, m4E-BP2]
Seturuman, A., et al. (2018). BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion. Breast Cancer Research doi: 10.1186/s13058-018-1046-3 [GeneHero™ clone expressing sgRNA targeting BHLHE40]
Raas, Q., et al. (2018). A microglial cell model for acyl-CoA oxidase 1 deficiency. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids doi: 10.1016/j.bbalip.2018.10.005 [GeneHero™ clone expressing sgRNA]
Jakimo, N., et al. (2018). Chimeric DNA:RNA Guide for High Accuracy Cas9 Genome Editing. United States Patent Application 20180282722 [GeneHero™ HEK293 Cas9-expressing stable cell line]
Wei, N., et al. (2018). Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. Oncogene doi: 10.1038/s41388-018-0547-y [GeneHero™ clone expressing sgRNA targeting STAT3]
Gulyaeva, O., et al. (2018). Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells. Cell Reports doi:10.1016/j.celrep.2018.09.086 [GeneHero™ clone expressing sgRNA targeting Meis1]
Chua, M.D., et al. (2018). Klebsiella pneumoniae disassembles host microtubules in lung epithelial cells. Cellular Microbiology doi: 10.1111/cmi.12977 [GeneHero™ clones expressing sgRNA targeting KANAL1, KATNB1]
Raas, Q., et al. (2018). A microglial cell model for acyl-CoA oxidase 1 deficiency. BBA – Molecular and Cell Biology of Lipids doi: 10.1016/j.bbalip.2018.10.005 [GeneHero™ clone expressing sgRNA targeting Acox1]

2017

Lo, C.L., et al. (2017). Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics. Scientific Reports doi: 10.1038/srep42047 [Genome-TALER™ clone targeted to Ascl1]
Teng, Y., et al. (2017). MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nature Communications doi: 10.1038/ncomms14448 [Lentiviral particles expressing sgRNA targeting MVP]
Shen, J.P., et al. (2017). Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions. Nature Methods doi 10.1038/nmeth.4225 [HeLa, HEK293T and A549 Cas9-expressing stable cell lines]
Blanco, G., et al. (2017). IGFN1_v1 is required for myoblast fusion and differentiation. PLoS ONE, In press. [sgRNA and donor clones targeting Igfn1 exon 13]
Ji, Q., et al. (2017). Genetically engineered cell lines for α1-antitrypsin expression. Biotechnology Letters doi: 10.1007/s10529-017-2391-5 [Genome-CRISP™ human AAVS1 Safe Harbor Knock-in kit and AAT knock-in ORF donor clone].
Jin, K., et al. (2017). Crosstalk between stromal components and tumor cells of TNBC via secreted factors enhances tumor growth and metastasis. Oncotarget doi:10.18632/oncotarget.19417 [Genome-CRISP™ sgRNA clones targeting CXCR2]
Leonova, K., et al. (2017). Transcription of Repeats Activates INterfern (TRAIN) in response to chromatin destabilization induced with anti-cancer small molecule, bioRxiv doi: 10.1101/142471 [Genome-CRISP™ sgRNA clones targeting ZBP1]
Bartolomeo, R., et al. (2017). mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. The Journal of Clinical Investigation doi: 10.1172/JCI94130 [Genome-CRISP™ sgRNA clone targeting Gusb]
Morita, M., et al. (2017). mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Molecular Cell doi: 10.1016/j.molcel.2017.08.013 [Genome-CRISP™ sgRNA clones targeting 4E-BP1 and 4E-BP2]
Murao, N., et al. (2017). Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β -cell glutamate signaling for incretin-induced insulin secretion. PLoS ONE doi: 10.137 1/journal.po ne.01872 [Cas9 D10 nickase expression clone and sgRNA expression clones]
Borque, C., et al. (2017). H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells. Toxicology and Applied Pharmacology doi: 10.1016/j.taap.2017.11.004 [Genome-CRISP™ CRISPR-Cas9 clone for CSE gene knockout]
Fan, Q., et al. (2017). The novel ZIP4 regulation and its role in ovarian cancer. Oncotarget doi: 10.18632/oncotarget.21435 [ZIP4 and PPARr lentiviral CRISPR vectors]
Sun, X., et al. (2017). Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP-Activated Protein Kinase. Molecular Nutrition and Food Research doi: 10.1002/mnfr.201700536 [AMPK CRISPR vectors]
Huang, F., et al. (2017). δ-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma. Oncology Reports doi: 10.3892/or.2017.6140 [Genome-CRISP™ CRISPR-Cas9 clone for Ctnnd2 gene knockout]
Shuang, T., et al. (2017). The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells. Biochemical Pharmacology doi: 10.1016/j.bcp.2017.12.009 [Genome-CRISP™ CRISPR-Cas9 clone for IGF-1R gene knockout]
Jin, L., et al. (2017). The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Molecular Cell doi: 10.1016/j.molcel.2017.11.025 [Genome-CRISP™ CRISPR-Cas9 clones for LKB1 and CamKK2 gene knockout]
Ikeda, M., et al. (2017). Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle. Scientific Reports doi: 10.1038/s41598-017-17968-w [IndelCheck™ Insertion/deletion detection system]

2016

Qi, C. et al. (2016) HEK293T Cells Are Heterozygous for CCR5 Delta 32 Mutation. PLOS ONE, April 4, 2016 http://dx.doi.org/10.1371/journal.pone.0152975. [T7E1 nuclease].
Hsu, PY. et al. (2016) Spatiotemporal control of estrogen-responsive transcription in ERα-positive breast cancer cells. Oncogene, 35, 2379–2389; doi:10.1038/onc.2015.298; published online 24 August 2015. [DEREs, sgRNA contructs and validation].
Blackburn, JB. Et al. (2016) COG Complex complexities: Detailed characterization of a complete set of HEK293T cells lacking individual COG subunits. Frontiers in Cell and Developmental Biology, 2016; 4: 23. [Cog5, Cog2, Cog7 sgRNA].
Hu, B., et al. (2016). A Novel Missense Mutation of CMT2P Alters Transcription Machinery. Annals of Neurobiology doi: 10.1002/ana.24776 [LRSAM1 CRISPR sgRNA clone]
Bahal, R., et al. (2016). In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nature Communications doi: 10.1038/ncomms13304 [Cas9 and sgRNA clones targeting mouse b-globin]

2015

Zhang, J. et al. (2015) Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene, 35, 1926-1942 (14 April 2016) | doi:10.1038/onc.2015.256-. [CRISPR-Cas9 genome editing system for FAK]
Wu, J. et al. (2015) Decreased RECQL5 correlated with disease progression of osteosarcoma. Biochemical and Biophysical Research Communications, Volume 467, Issue 4, 27 November 2015, Pages 617–622. [AAVS1 safe harbor gene knock-in kit]
Foss, O. et al. (2015) Role of FOXA genes in maintaining transformed phenotype in human bronchial epithelial cells. NTNU Open, 2015. [FOXA1 gene, sgRNA, donor, AAVS1 safe harbor gene knock-in kit].

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