All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

sgRNA clones for CRISPRa and CRISPRi

Both CRISPRa and CRISPRi systems use a dCas9 construct fused to either activators or repressors to leverage the power of PAM-anchored targeting for transcriptional modulation. These systems simply bring the precision of CRISPR to gene modulation.

CRISPR activation sgRNA clones

Vector	Promoter	CRISPR option	Selection Marker / Reporter Gene	Vector Type	Vector Map
pCRISPR-AG01	U6	CRISPRa dCas9 SAM	Puro / eGFP	Lentiviral
pCRISPR-AG02	U6	CRISPRa dCas9 SAM	Puro / eGFP	Lentiviral

CRISPR interference sgRNA clones

Vector	Promoter	CRISPR option	Selection Marker / Reporter Gene	Vector Type	Vector Map
pCRISPR-AB04	U6	CRISPRi dCas9-KRAB	Puro / mCherry	Lentiviral

sgRNA clones for CRISPRa and CRISPRi

Activate the transcription of any endogenous gene of interest, without cutting the DNA

Repress gene expression, without cutting the DNA