Resources

Cas9 Stable Cell Lines: Powerful Tools for CRISPR sgRNA Library Screening and More

Ed Davis, Ph.D. [Tab:Introduction] The CRISPR-Cas9 system for genome editing is rapidly transforming research in biology and medicine, due to its ease-of-design, efficiency, specificity, and relatively low cost (Wang, et al., 2016). In mammalian cell culture systems,...
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Using GeneCopoeia FISH Probes in a CRISPR-mediated Genome Editing Workflow

  Qihong Xu, Meng Zhang, Xueming Xu, and Ed Davis Introduction Immortalized mammalian cell lines, while providing convenient model systems for biomedical and pharmaceutical research, often carry 3 or more copies of a chromosome or gene (Wistuba, et al., 1998;...
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Genome Editing: Applications For GeneCopoeia CRISPR sgRNA Libraries

  Ed Davis, Ph.D. Biomedical researchers are enjoying a Renaissance in functional genomics, which aims to use a wealth of DNA sequence information—most notably, the complete sequence of the human genome—to determine the natural roles of the genes...
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Genome Editing: HDR Donors For Gene Knockout, Mutagenesis, Tagging, and Safe Harbor Knock-in

  Ed Davis, Ph.D. Genome Editing—making specific changes at targeted genomic sites—is fundamentally important to researchers in biology and medicine (Bogdanove & Voytas, 2011; van der Oost, et al., 2013). Two popular genome editing technologies...
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