Clone sets

E3 ubiquitin ligases

Introduction E3 ubiquitin ligases are key components of the ubiquitin–proteasome system, selecting and tagging target proteins for degradation or regulation. With over 600 members, they control vital processes such as cell cycle, DNA repair, and immune signaling....

Immune Checkpoint

Introduction Immune checkpoints are regulators of the immune system. The recognition of the antigenic peptide-MHC I/II complex on antigen presenting cells (APCs) through the T cell receptor (TCR) initiates T cell–mediated immunity. However, additional co-stimulatory...

Chemokines and chemokine receptors

Introduction Cancer is a collection of diseases characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Based on their role in cancer progression, driver genes can be classified into two main categories: oncogenes and tumor...

Synaptic genes in autoimmune disease of nervous system

Introduction The nervous system includes the central nervous system (CNS) and the peripheral nervous system (PNS). Viral infections, poisoning, genetic defects, immune damage, and metabolic disorders may trigger the development of neurological diseases. Neurological...

Immune Checkpoint

Introduction Immune checkpoints are regulators of the immune system. The recognition of the antigenic peptide-MHC I/II complex on antigen presenting cells (APCs) through the T cell receptor (TCR)...

Chemokines and chemokine receptors

Introduction Cancer is a collection of diseases characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Based on their role in cancer progression, driver...

Protease

Introduction Proteases are widely distributed in animals, plants, and microorganisms, and their main role is to...

read more

Kinases

Introduction Kinases are enzymes that catalyze the transfer of phosphate groups from high-energy phosphorus-containing...

read more

Histones

Introduction Histones are alkaline proteins found in the chromatin of eukaryotic and prokaryotic cells, which form the...

read more

GPCRs

Introduction G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors found only in...

read more

Epigenetics

Introduction Epigenetics is the study of heritable changes in gene function that do not involve alterations to the DNA...

read more

CDs

Introduction Cluster of differentiation (CD) antigens are cell surface molecules expressed on leukocytes and other...

read more