Synaptic genes in autoimmune disease of nervous system
Introduction
The nervous system includes the central nervous system (CNS) and the peripheral nervous system (PNS). Viral infections, poisoning, genetic defects, immune damage, and metabolic disorders may trigger the development of neurological diseases. Neurological autoimmune diseases are diseases in which the body’s immune system mistakenly attacks its own nervous system, causing damage to the tissue structure and function of the nervous system. This kind of disease has a wide range of damage, and the clinical manifestations are complex and varied, which can involve the central nervous system, peripheral nervous system and nerve-muscle joints, resulting in neuronal or axonal damage, myelin loss, nerve-muscle joint destruction and other pathological changes.
Examples of CNS autoimmune diseases include optic neuromyelitis optica spectrum disease (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), autoimmune encephalitis (AE), and vasculitis of the CNS. These diseases have relatively independent clinical features, and some specific antibodies play an indispensable role in the diagnosis and differential diagnosis of the diseases. For example, patients with NMOSD may be positive for AQP4 antibodies, and patients with ADEM may be positive for MOG antibodies.
This clone set can be used for the development of biomarkers for neuroimmune diseases, expanding and improving the spectrum of humoral markers for neuroimmune diseases, which can be further used for differential diagnosis, disease course monitoring, efficacy and prognosis assessment, and drug target screening.
Clone set information
Clone list
For clone list please contact us at 1-301-762-0888 or
inquiry@genecopoeia.com if you have any questions.
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