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Synaptic genes in autoimmune disease of nervous system

Introduction

The nervous system includes the central nervous system (CNS) and the peripheral nervous system (PNS). Viral infections, poisoning, genetic defects, immune damage, and metabolic disorders may trigger the development of neurological diseases. Neurological autoimmune diseases are diseases in which the body’s immune system mistakenly attacks its own nervous system, causing damage to the tissue structure and function of the nervous system. This kind of disease has a wide range of damage, and the clinical manifestations are complex and varied, which can involve the central nervous system, peripheral nervous system and nerve-muscle joints, resulting in neuronal or axonal damage, myelin loss, nerve-muscle joint destruction and other pathological changes.

Examples of CNS autoimmune diseases include optic neuromyelitis optica spectrum disease (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), autoimmune encephalitis (AE), and vasculitis of the CNS. These diseases have relatively independent clinical features, and some specific antibodies play an indispensable role in the diagnosis and differential diagnosis of the diseases. For example, patients with NMOSD may be positive for AQP4 antibodies, and patients with ADEM may be positive for MOG antibodies.

This clone set can be used for the development of biomarkers for neuroimmune diseases, expanding and improving the spectrum of humoral markers for neuroimmune diseases, which can be further used for differential diagnosis, disease course monitoring, efficacy and prognosis assessment, and drug target screening.

Clone set information

Cat. no.	Species	Gene	Vector	Vector Type	Price
OC-GF021-M02	Human	2137	pReceiver-M02	Expression-ready Non-viral	Inquire
OC-GF021-M35	Human	2137	pReceiver-M35	Expression-ready Non-viral	Inquire
OC-GF021-M98	Human	2137	pReceiver-M98	Expression-ready Non-viral	Inquire
OC-GF021-Lv105	Human	2137	pReceiver-Lv105	Expression-ready Lentiviral	Inquire
OC-GF021-Lv242	Human	2137	pReceiver-Lv242	Expression-ready Lentiviral	Inquire
OC-GF021-GC	Human	2137	pDONR™ Vector	Gateway shuttle	Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.

Symbol	Accession	Species	Description	ORF length(bp)	Product ID
HTR3B	NM_006028.5	Human	Homo sapiens 5-hydroxytryptamine receptor 3B (HTR3B), transcript variant 1, mRNA.	1326	GC-U0382
KCNH1	NM_172362.3	Human	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA.	2970	GC-Z2907
PCDH8	NM_002590.4	Human	Homo sapiens protocadherin 8 (PCDH8), transcript variant 1, mRNA.	3213	GC-A6372
MT3	NM_005954.4	Human	Homo sapiens metallothionein 3 (MT3), mRNA.	207	GC-T3737
NR4A1	NM_001202233.2	Human	Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 3, mRNA.	1836	GC-A1310
NR4A1	NM_001202234.2	Human	Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 4, mRNA.	1959	GC-A4501
NR4A1	NM_173157.3	Human	Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 2, mRNA.	1797	GC-A1311
CAPRIN1	NM_005898.5	Human	Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript variant 1, mRNA.	2130	GC-Y3977
CAPRIN1	NM_203364.3	Human	Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript variant 2, mRNA.	2085	GC-Z5446
GPR176	NM_001271854.2	Human	Homo sapiens G protein-coupled receptor 176 (GPR176), transcript variant 2, mRNA.	1545	GC-A3513
GPR176	NM_007223.3	Human	Homo sapiens G protein-coupled receptor 176 (GPR176), transcript variant 1, mRNA.	1548	GC-A0542
GRM2	NM_000839.5	Human	Homo sapiens glutamate metabotropic receptor 2 (GRM2), transcript variant 1, mRNA.	2619	GC-A0723
YBX1	NM_004559.5	Human	Homo sapiens Y-box binding protein 1 (YBX1), transcript variant 1, mRNA.	975	GC-Z2227
FZD4	NM_012193.4	Human	Homo sapiens frizzled class receptor 4 (FZD4), mRNA.	1614	GC-U0507
CORO1C	NM_001276471.2	Human	Homo sapiens coronin 1C (CORO1C), transcript variant 3, mRNA.	1425	GC-V0380
PDE7B	NM_018945.4	Human	Homo sapiens phosphodiesterase 7B (PDE7B), mRNA.	1353	GC-U0877
SLC40A1	NM_014585.6	Human	Homo sapiens solute carrier family 40 member 1 (SLC40A1), mRNA.	1716	GC-U0652
RAB26	NM_001308053.1	Human	Homo sapiens RAB26, member RAS oncogene family (RAB26), transcript variant 2, mRNA.	573	GC-U0581
RPS13	NM_001017.3	Human	Homo sapiens ribosomal protein S13 (RPS13), mRNA.	456	GC-F0132
RPS18	NM_022551.3	Human	Homo sapiens ribosomal protein S18 (RPS18), mRNA.	459	GC-F0609
RPS14	NM_001025071.2	Human	Homo sapiens ribosomal protein S14 (RPS14), transcript variant 1, mRNA.	456	GC-F0356
RPS16	NM_001020.6	Human	Homo sapiens ribosomal protein S16 (RPS16), transcript variant 1, mRNA.	441	GC-F0306
RPS15A	NM_001030009.2	Human	Homo sapiens ribosomal protein S15a (RPS15A), transcript variant 1, mRNA.	393	GC-F0583
RTN3	NM_006054.4	Human	Homo sapiens reticulon 3 (RTN3), transcript variant 1, mRNA.	711	GC-V0138
RTN3	NM_201428.3	Human	Homo sapiens reticulon 3 (RTN3), transcript variant 2, mRNA.	3042	GC-Z3044
UNC5C	NM_003728.3	Human	Homo sapiens unc-5 netrin receptor C (UNC5C), mRNA.	2796	GC-A3946
DNAJB1	NM_001300914.2	Human	Homo sapiens DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), transcript variant 2, mRNA.	723	GC-I2174
DNAJB1	NM_006145.3	Human	Homo sapiens DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), transcript variant 1, mRNA.	1023	GC-T0399
GABARAP	NM_007278.2	Human	Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA.	354	GC-I0146
ARF1	NM_001658.4	Human	Homo sapiens ADP ribosylation factor 1 (ARF1), transcript variant 4, mRNA.	546	GC-A0306
NETO2	NM_018092.5	Human	Homo sapiens neuropilin and tolloid like 2 (NETO2), transcript variant 1, mRNA.	1578	GC-H0314
ATAD1	NM_032810.4	Human	Homo sapiens ATPase family AAA domain containing 1 (ATAD1), transcript variant 1, mRNA; nuclear gene for mitochondrial product.	1086	GC-E1659
CALM3	NM_001329925.2	Human	Homo sapiens calmodulin 3 (CALM3), transcript variant 6, mRNA.	342	GC-A8631
CALM3	NM_005184.4	Human	Homo sapiens calmodulin 3 (CALM3), transcript variant 1, mRNA.	450	GC-A0377
GJD2	NM_020660.3	Human	Homo sapiens gap junction protein delta 2 (GJD2), mRNA.	966	GC-T1262
STX10	NM_001271611.2	Human	Homo sapiens syntaxin 10 (STX10), transcript variant 4, mRNA.	603	GC-Z0174
STX10	NM_003765.3	Human	Homo sapiens syntaxin 10 (STX10), transcript variant 1, mRNA.	750	GC-U0157
SPARCL1	NM_001128310.3	Human	Homo sapiens SPARC like 1 (SPARCL1), transcript variant 1, mRNA.	1995	GC-Z6357
SPARCL1	NM_001291977.2	Human	Homo sapiens SPARC like 1 (SPARCL1), transcript variant 4, mRNA.	1620	GC-A5795
SPARCL1	NM_004684.6	Human	Homo sapiens SPARC like 1 (SPARCL1), transcript variant 2, mRNA.	1995	GC-D0257
FBXL20	NM_032875.3	Human	Homo sapiens F-box and leucine rich repeat protein 20 (FBXL20), transcript variant 1, mRNA.	1311	GC-Z1248
BLOC1S6	NM_012388.4	Human	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 6 (BLOC1S6), transcript variant 2, mRNA.	519	GC-U0952
MKLN1	NM_001321316.2	Human	Homo sapiens muskelin 1 (MKLN1), transcript variant 3, mRNA.	1587	GC-T2699
MKLN1	NM_013255.5	Human	Homo sapiens muskelin 1 (MKLN1), transcript variant 2, mRNA.	2208	GC-T9061
TTYH1	NM_020659.4	Human	Homo sapiens tweety family member 1 (TTYH1), transcript variant 1, mRNA.	1353	GC-U1041
NQO1	NM_000903.3	Human	Homo sapiens NAD(P)H quinone dehydrogenase 1 (NQO1), transcript variant 1, mRNA.	825	GC-Z0563
NQO1	NM_001025433.2	Human	Homo sapiens NAD(P)H quinone dehydrogenase 1 (NQO1), transcript variant 2, mRNA.	723	GC-Z3579
KCNN2	NM_170775.3	Human	Homo sapiens potassium calcium-activated channel subfamily N member 2 (KCNN2), transcript variant 2, mRNA.	696	GC-L8848
SLC12A5	NM_001134771.1	Human	Homo sapiens solute carrier family 12 member 5 (SLC12A5), transcript variant 1, mRNA.	3420	GC-Y4646
SLC12A5	NM_020708.4	Human	Homo sapiens solute carrier family 12 member 5 (SLC12A5), transcript variant 2, mRNA.	3351	GC-Y4733