All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

E3 ubiquitin ligases

Introduction

E3 ubiquitin ligases are key components of the ubiquitin–proteasome system (UPS), selecting and tagging target proteins for degradation or regulation. They are responsible for selecting and labelling target proteins for degradation or regulation. The UPS system is the main mechanism by which cells degrade proteins. Its core function involves the coordinated action of E1s, E2s and E3 ubiquitin ligases, which work together to attach ubiquitin molecules to target proteins and mark them for proteasomal degradation. E3 ligases recognise specific substrate proteins and transfer ubiquitin to lysine residues on these proteins.

With over 600 members, they control vital processes such as cell cycle, DNA repair, and immune signaling. Dysregulated E3 activity drives cancer, neurodegeneration, and inflammation, making E3s important targets for mechanistic studies and drug development.

Fig. Overview of the cascade process of ubiquitination.

Genecopoeia offers E3 ubiquitin ligases clone set for mechanistic studies and drug development.

Clone set information

Cat. no.	Species	Genes	Vector	Vector Type	Price
OC-GF026-M02	Human	607	pReceiver-M02	Expression-ready Non-viral	Inquire
OC-GF026-M35	Human	607	pReceiver-M35	Expression-ready Non-viral	Inquire
OC-GF026-M98	Human	607	pReceiver-M98	Expression-ready Non-viral	Inquire
OC-GF026-Lv105	Human	607	pReceiver-Lv105	Expression-ready Lentiviral	Inquire
OC-GF026-Lv242	Human	607	pReceiver-Lv242	Expression-ready Lentiviral	Inquire
OC-GF026-GC	Human	607	pDONR™ Vector	Gateway shuttle	Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.

Symbol	Accession	Species	Description	ORF length(bp)	Product ID
TRAF2	NM_021138.4	Human	Homo sapiens TNF receptor associated factor 2 (TRAF2), mRNA.	1506	GC-A1295
TRAF6	NM_004620.4	Human	Homo sapiens TNF receptor associated factor 6 (TRAF6), transcript variant 2, mRNA.	1569	GC-I3719
MDM2	NM_002392.6	Human	Homo sapiens MDM2 proto-oncogene (MDM2), transcript variant 1, mRNA.	1494	GC-Z2484
TRAF3	NM_145725.3	Human	Homo sapiens TNF receptor associated factor 3 (TRAF3), transcript variant 1, mRNA.	1707	GC-H0235
BIRC2	NM_001256163.1	Human	Homo sapiens baculoviral IAP repeat containing 2 (BIRC2), transcript variant 2, mRNA.	1857	GC-B0151
BIRC3	NM_001165.5	Human	Homo sapiens baculoviral IAP repeat containing 3 (BIRC3), transcript variant 1, mRNA.	1815	GC-Z7357
XIAP	NM_001167.4	Human	Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript variant 1, mRNA.	1494	GC-H4489
SOCS3	NM_003955.5	Human	Homo sapiens suppressor of cytokine signaling 3 (SOCS3), transcript variant 1, mRNA.	678	GC-N0037
RBX1	NM_014248.4	Human	Homo sapiens ring-box 1 (RBX1), mRNA.	327	GC-R0022
TRAF5	NM_001033910.3	Human	Homo sapiens TNF receptor associated factor 5 (TRAF5), transcript variant 3, mRNA.	1674	GC-K1738
MAP3K1	NM_005921.2	Human	Homo sapiens mitogen-activated protein kinase kinase kinase 1 (MAP3K1), mRNA.	4539	GC-Y4393
BTRC	NM_033637.4	Human	Homo sapiens beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript variant 1, mRNA.	1818	GC-Z1059
FBXW11	NM_012300.3	Human	Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 3, mRNA.	1629	GC-Z2736
SOCS1	NM_003745.2	Human	Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA.	636	GC-K2201
CBL	NM_005188.4	Human	Homo sapiens Cbl proto-oncogene (CBL), mRNA.	2721	GC-A1309
SKP2	NM_005983.4	Human	Homo sapiens S-phase kinase associated protein 2 (SKP2), transcript variant 1, mRNA.	1275	GC-H1844
BRCA1	NM_007300.4	Human	Homo sapiens BRCA1 DNA repair associated (BRCA1), transcript variant 2, mRNA.	5655	GC-Z8230
CBLB	NM_001321788.2	Human	Homo sapiens Cbl proto-oncogene B (CBLB), transcript variant 3, mRNA.	2949	GC-Z7996
PML	NM_033238.3	Human	Homo sapiens PML nuclear body scaffold (PML), transcript variant 1, mRNA.	2649	GC-X0910
TNFAIP3	NM_001270507.2	Human	Homo sapiens TNF alpha induced protein 3 (TNFAIP3), transcript variant 2, mRNA.	2373	GC-K6040
PRKN	NM_004562.3	Human	Homo sapiens parkin RBR E3 ubiquitin protein ligase (PRKN), transcript variant 1, mRNA.	1398	GC-Q0218
KEAP1	NM_012289.4	Human	Homo sapiens kelch like ECH associated protein 1 (KEAP1), transcript variant 2, mRNA.	1875	GC-M0487
SMURF1	NM_020429.3	Human	Homo sapiens SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 1, mRNA.	2274	GC-T4829
SMURF2	NM_022739.4	Human	Homo sapiens SMAD specific E3 ubiquitin protein ligase 2 (SMURF2), mRNA.	2247	GC-W1022
ANAPC11	NM_001002244.2	Human	Homo sapiens anaphase promoting complex subunit 11 (ANAPC11), transcript variant 1, mRNA.	591	GC-Z2100
BIRC7	NM_139317.3	Human	Homo sapiens baculoviral IAP repeat containing 7 (BIRC7), transcript variant 1, mRNA.	897	GC-W1020
SOCS2	NM_001270471.2	Human	Homo sapiens suppressor of cytokine signaling 2 (SOCS2), transcript variant 6, mRNA.	597	GC-I0120
ITCH	NM_001324197.2	Human	Homo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 4, mRNA.	2712	GC-T7640
DDB1	NM_001923.5	Human	Homo sapiens damage specific DNA binding protein 1 (DDB1), mRNA.	3423	GC-M0025
BMI1	NM_005180.9	Human	Homo sapiens BMI1 proto-oncogene, polycomb ring finger (BMI1), mRNA.	981	GC-B0015
SIAH1	NM_001006610.2	Human	Homo sapiens siah E3 ubiquitin protein ligase 1 (SIAH1), transcript variant 2, mRNA.	942	GC-Z1429
SOCS4	NM_199421.2	Human	Homo sapiens suppressor of cytokine signaling 4 (SOCS4), transcript variant 1, mRNA.	1323	GC-T3502
VHL	NM_000551.4	Human	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.	642	GC-K5438
ZBTB17	NM_003443.3	Human	Homo sapiens zinc finger and BTB domain containing 17 (ZBTB17), transcript variant 2, mRNA.	2412	GC-M0431
NEDD4L	NM_015277.6	Human	Homo sapiens NEDD4 like E3 ubiquitin protein ligase (NEDD4L), transcript variant d, mRNA.	2868	GC-T8639
DPF1	NM_001135156.3	Human	Homo sapiens double PHD fingers 1 (DPF1), transcript variant 3, mRNA.	999	GC-Z5756
RBCK1	NM_031229.4	Human	Homo sapiens RANBP2-type and C3HC4-type zinc finger containing 1 (RBCK1), transcript variant 2, mRNA.	1533	GC-A1611
RNF31	NM_017999.5	Human	Homo sapiens ring finger protein 31 (RNF31), transcript variant 1, mRNA.	3219	GC-Z1067
TRAF4	NM_004295.4	Human	Homo sapiens TNF receptor associated factor 4 (TRAF4), mRNA.	1413	GC-T0396
TRIM25	NM_005082.5	Human	Homo sapiens tripartite motif containing 25 (TRIM25), mRNA.	1893	GC-A3061
VPS11	NM_021729.6	Human	Homo sapiens VPS11 core subunit of CORVET and HOPS complexes (VPS11), transcript variant 1, mRNA.	2826	GC-Z7830
VPS41	NM_014396.4	Human	Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant 1, mRNA.	2565	GC-A3049
NSD2	NM_133335.4	Human	Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 3, mRNA.	4098	GC-W0268
BCL6	NM_001130845.2	Human	Homo sapiens BCL6 transcription repressor (BCL6), transcript variant 2, mRNA.	2121	GC-Z6442
ZBTB16	NM_001018011.3	Human	Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant 2, mRNA.	2022	GC-T0615
UBE3A	NM_000462.5	Human	Homo sapiens ubiquitin protein ligase E3A (UBE3A), transcript variant 2, mRNA.	2628	GC-H1407
AMFR	NM_001144.6	Human	Homo sapiens autocrine motility factor receptor (AMFR), transcript variant 3, mRNA.	1932	GC-T9295
CBLC	NM_012116.4	Human	Homo sapiens Cbl proto-oncogene C (CBLC), transcript variant 1, mRNA.	1425	GC-A3125
FANCL	NM_001114636.2	Human	Homo sapiens FA complementation group L (FANCL), transcript variant 1, mRNA.	1143	GC-Z6242
MGRN1	NM_015246.4	Human	Homo sapiens mahogunin ring finger 1 (MGRN1), transcript variant 1, mRNA.	1731	GC-Y2081