Chemokines and chemokine receptors

Introduction

Cancer is a collection of diseases characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Based on their role in cancer progression, driver genes can be classified into two main categories: oncogenes and tumor suppressor genes. Oncogene addiction refers to the phenomenon that certain tumours depend on one or more activated oncogenes, also known as driver oncogenes, to maintain their malignant biological phenotype.
Chemokines, or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addition to playing a major role in the activation of host immune responses, chemokines are important for biological processes, including morphogenesis and wound healing, as well as in the pathogenesis of diseases like cancers.
Chemokines have been classified into four main subfamilies: CXC, CC, CX3C and C. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, includes CCL14, CCL19, CCL20, CCL21, CCL25, CCL27, CXCL12 and CXCL13. This classification is not strict, for example, CCL20 can act also as pro-inflammatory chemokine. Others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. These chemokines are formed under pathological conditions (on pro-inflammatory stimuli, such as IL-1, TNF-alpha, LPS, or viruses) and actively participate in the inflammatory response attracting immune cells to the site of inflammation, such as CXCL-8, CCL2, CCL3, CCL4, CCL5, CCL11, CXCL10.
Chemokine receptors are G protein-coupled receptors containing 7 transmembrane domains that are found on the surface of leukocytes. Chemokine receptors associate with G-proteins to transmit cell signals following ligand binding. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production

Clone set information

Cat. no. Species Gene Vector Vector Type Price
OC-GF023-M02 Human 69 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF023-M35 Human 69 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF023-M98 Human 69 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF023-Lv105 Human 69 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF023-Lv242 Human 69 pReceiver-Lv242 Expression-ready Lentiviral Inquire
OC-GF023-GC Human 69 pDONR™ Vector Gateway shuttle Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
CCL1 NM_002981.2 Human Homo sapiens C-C motif chemokine ligand 1 (CCL1), mRNA. 291 GC-A0176
CCL2 NM_002982.4 Human Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA. 300 GC-Q0327
CCL3 NM_002983.3 Human Homo sapiens C-C motif chemokine ligand 3 (CCL3), transcript variant 1, mRNA. 279 GC-Z2490
CCL4 NM_002984.4 Human Homo sapiens C-C motif chemokine ligand 4 (CCL4), mRNA. 279 GC-A8645
CCL5 NM_001278736.2 Human Homo sapiens C-C motif chemokine ligand 5 (CCL5), transcript variant 2, mRNA. 465 GC-I2496
CCL5 NM_002985.3 Human Homo sapiens C-C motif chemokine ligand 5 (CCL5), transcript variant 1, mRNA. 276 GC-A3676
CCL7 NM_006273.4 Human Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA. 300 GC-O0062
CCL8 NM_005623.3 Human Homo sapiens C-C motif chemokine ligand 8 (CCL8), mRNA. 300 GC-Z2678
CCL11 NM_002986.3 Human Homo sapiens C-C motif chemokine ligand 11 (CCL11), mRNA. 294 GC-Z7461
CCL13 NM_005408.3 Human Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA. 297 GC-N0005
CCL14 NM_032962.5 Human Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 2, mRNA. 330 GC-Z3767
CCL14 NM_032963.4 Human Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA. 282 GC-N0003
CCL15 NM_032965.6 Human Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA. 342 GC-X0728
CCL16 NM_004590.4 Human Homo sapiens C-C motif chemokine ligand 16 (CCL16), mRNA. 363 GC-N0036
CCL17 NM_002987.3 Human Homo sapiens C-C motif chemokine ligand 17 (CCL17), mRNA. 285 GC-N0017
CCL18 NM_002988.4 Human Homo sapiens C-C motif chemokine ligand 18 (CCL18), mRNA. 270 GC-N0039
CCL19 NM_006274.3 Human Homo sapiens C-C motif chemokine ligand 19 (CCL19), mRNA. 297 GC-I0009
CCL20 NM_001130046.2 Human Homo sapiens C-C motif chemokine ligand 20 (CCL20), transcript variant 2, mRNA. 288 GC-N0056
CCL20 NM_004591.3 Human Homo sapiens C-C motif chemokine ligand 20 (CCL20), transcript variant 1, mRNA. 291 GC-Z4471
CCL21 NM_002989.4 Human Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA. 405 GC-M0488
CCL22 NM_002990.5 Human Homo sapiens C-C motif chemokine ligand 22 (CCL22), mRNA. 282 GC-Z9059
CCL23 NM_005064.6 Human Homo sapiens C-C motif chemokine ligand 23 (CCL23), transcript variant CKbeta8, mRNA. 414 GC-Z2590
CCL23 NM_145898.4 Human Homo sapiens C-C motif chemokine ligand 23 (CCL23), transcript variant CKbeta8, mRNA. 363 GC-N0012
CCL24 NM_002991.3 Human Homo sapiens C-C motif chemokine ligand 24 (CCL24), transcript variant 2, mRNA. 360 GC-A3100
CCL25 NM_001201359.2 Human Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 2, mRNA. 450 GC-Z9647
CCL25 NM_005624.4 Human Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 1, mRNA. 453 GC-N0051
CCL26 NM_006072.4 Human Homo sapiens C-C motif chemokine ligand 26 (CCL26), mRNA. 285 GC-N0034
CCL27 NM_006664.4 Human Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA. 339 GC-N0035
CCL28 NM_001301875.2 Human Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA. 243 GC-A6116
CCL28 NM_148672.3 Human Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 1, mRNA. 384 GC-W0559
CXCL1 NM_001511.4 Human Homo sapiens C-X-C motif chemokine ligand 1 (CXCL1), transcript variant 1, mRNA. 324 GC-G0095
CXCL2 NM_002089.4 Human Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA. 324 GC-A0267
CXCL3 NM_002090.3 Human Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA. 324 GC-N0068
PF4 NM_002619.4 Human Homo sapiens platelet factor 4 (PF4), transcript variant 1, mRNA. 306 GC-G0251
PF4 NM_001363352.1 Human Homo sapiens platelet factor 4 (PF4), transcript variant 2, mRNA. 333 GC-I8439
CXCL5 NM_002994.5 Human Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA. 345 GC-A1113
CXCL6 NM_002993.4 Human Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA. 345 GC-Y2027
PPBP NM_002704.3 Human Homo sapiens pro-platelet basic protein (PPBP), mRNA. 387 GC-G0161
CXCL8 NM_000584.4 Human Homo sapiens C-X-C motif chemokine ligand 8 (CXCL8), transcript variant 1, mRNA. 300 GC-I0329
CXCL9 NM_002416.3 Human Homo sapiens C-X-C motif chemokine ligand 9 (CXCL9), mRNA. 378 GC-A0353
CXCL10 NM_001565.4 Human Homo sapiens C-X-C motif chemokine ligand 10 (CXCL10), transcript variant 1, mRNA. 297 GC-T7063
CXCL11 NM_001302123.2 Human Homo sapiens C-X-C motif chemokine ligand 11 (CXCL11), transcript variant 2, mRNA. 321 GC-A6118
CXCL11 NM_005409.5 Human Homo sapiens C-X-C motif chemokine ligand 11 (CXCL11), transcript variant 1, mRNA. 285 GC-N0032
CXCL12 NM_000609.7 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 2, mRNA. 282 GC-A0590
CXCL12 NM_001178134.2 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 4, mRNA. 423 GC-Z9616
CXCL12 NM_001277990.2 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 5, mRNA. 312 GC-A4545
CXCL12 NM_199168.4 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 1, mRNA. 270 GC-Z1991
CXCL13 NM_006419.3 Human Homo sapiens C-X-C motif chemokine ligand 13 (CXCL13), transcript variant 1, mRNA. 330 GC-N0028
CXCL17 NM_198477.3 Human Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA. 360 GC-Y2390
XCL1 NM_002995.3 Human Homo sapiens X-C motif chemokine ligand 1 (XCL1), mRNA. 345 GC-N0006