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Validated All-in-One™ qPCR Primer for CD109(NM_001159587.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002 [PubMed 11861284]). In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990 [PubMed 2346781]; Lin et al., 2002 [PubMed 11861284]).[supplied by OMIM].
Gene References into function
- Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. cDNA sequence determination and protein structure analysis given.
- A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.
- Findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins.
- CD109 plays a unique role in the regulation of isoform-specific TGF-beta signaling in keratinocytes.
- Found with a mutation in 7% of colon cancers studied.
- Findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas.
- the novel gene HEPT3 may function through its noncoding RNA and its overexpression may play a role in hepatocarcinogenesis [HEPT3]
- CD109 expression may play a role in the development of lung squamous cell carcinoma.
- Up-regulation of CD109 expression is associated with carcinogensis of the squamous epithelium of the oral cavity.