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Validated All-in-One™ qPCR Primer for MAP1LC3A(NM_032514.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene.
Gene References into function
- localization of LC3 to a membrane compartment by delipidation is negatively regulated by HsAtg4B
- NMR structure of human microtubule-associated protein light chain-3
- MAP-LC3 can act as an adaptor protein between microtubules and autophagosomes
- Phosphatidylserine and phosphatidylethanolamine are targets of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16
- LC3 residues Phe80 and Leu82, the equivalents of Phe77 and Phe79 in Atg8, are essential for its C-terminal cleavage.
- Muscle fibers of patients with inclusion body myositis show increased frequencies of Atg8/LC3(+) autophagosomes and that intracellular amyloid beta-protein colocalized with Atg8/LC3 in degenerating muscle fibers.
- The specific interaction between p62 and LC3, mediated by a 22-residue sequence of p62 containing an evolutionarily conserved motif, is instrumental in mediating autophagic degradation of the p62-positive bodies.
- Modification of LC3 occurs both during poliovirus infection and following expression of a single viral protein, a stable precursor termed 2BC.
- LC3 is responsible for recruiting p62 into autophagosomes, a process mediated by phenylalanine 52, located within the ubiquitin core, and the N-terminal region of the protein.
- The suppression of unfolded protein response or the suppression of expression of LC3 or Atg7, a protein that mediates LC3 lipidation, suppressed HCV replication.
- LC3 is upregulated in various gastrointestinal cancers and partly associated with Ki-67 inde; results suggest that LC3 expression is advantageous to cancer development especially in early-phase carcinogenesis