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Validated All-in-One™ qPCR Primer for MAPKAP1(NM_024117.4) Search again
Product ID:
HQP182140
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
JC310, MIP1, SIN1, SIN1b, SIN1g
Gene Description:
MAPK associated protein 1
Target Gene Accession:
NM_024117.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase.
Gene References into function
- Results demonstrate that Sin1 transcripts can use alternative polyadenylation signals and describe a number of Sin1 splice variants that potentially encode functionally different isoforms.
- The human Sin1 proteins form a complex with Jun N-terminal kinase.
- A novel MEKK2-interacting protein, Mip1, that regulates MEKK2 dimerization and activation by forming a complex with inactive and nonphosphorylated MEKK2, was identified.
- Sin1 is necessary for the assembly of TORC2 and for its capacity to phosphorylate Akt/PKB.
- Results reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function.
- Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling
- Sin1 may contribute to ATF-2 signaling specificity by acting as a nuclear scaffold.
- These data suggest that Sin1 is a mammalian Ras-inhibitor.
- MIP-1 delta expression is increased in RBM (RCC (Renal Cell Carcinoma) bone metastasis) relative to RCC and bone marrow, and may promote RBM-induced osteolysis by stimulating recruitment/differentiation of osteoclast precursors into mature osteoclasts
- SIN1 and PCBP2 are generally coregulated with large numbers of genes implicated in both cell survival and death and in cellular stress responses, including RNA translation and processing