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Validated All-in-One™ qPCR Primer for MTUS1(NM_020749.5) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways.
Gene References into function
- identified a tumor suppressor gene named MTSG1 at chromosome 8p21.3-22, encoding a mitochondrial protein, controlling cellular proliferation
- Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade
- Nucleotide variations result in amino-acid substitution or deletion of conserved structural motifs and also exonic splicing enhancer motifs and physiological splice sites, suggesting deleterious effects on ATIP function and/or expression. [REVIEW]
- MTUS1 encodes a family of proteins(ATIP1, ATIP3 and ATIP4), with potential important biological roles in tumor suppression and/or brain function.
- There is an association of the deletion variant of MTUS1 with a decreased risk for both familial and high-risk familial BC supporting its role in human cancer.