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Validated All-in-One™ qPCR Primer for RTN4(NM_153828.3) Search again
Product ID:
HQP179656
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ASY, NI220/250, NOGO, NSP, NSP-CL, Nbla00271, Nbla10545, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
Gene Description:
reticulon 4
Target Gene Accession:
NM_153828.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates.
Gene References into function
- The alteration in Nogo gene expression in muscle biopsy represents a potential diagnostic tool for the early stages of amyotrophic lateral sclerosis.
- Elevated expression of Nogo mRNA in schizophrenia was confirmed by RT-PCR. Nogo mRNA was found to contain a CAA insert polymorphism in the 3'-untranslated region.
- results describe the regulation of nogo expression through its promoter region
- ASY may be multi-functional, regulating apoptosis, tumor development, and neuronal regeneration [review]
- ER stress of highly overexpressed Nogo-B may lead to aversive cellular reactions under particular conditions. Our data do not support a function of Nogo-B as a physiological pro-apoptotic protein in certain types of cancer.
- ASYIP(ASY-interacting) protein co-localized with ASY in endoplasmic reticulum. Characterization of ASYIP gene may help clarify mechanism of ASY-induced apoptosis or Nogo-involved inhibition of neuronal regeneration in central nervous system.
- this study found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the European American and the African American.
- Nogo-B is a regulator of vascular homeostasis and remodeling broadens the functional scope of this family of proteins
- The steady-state level of reticulon 4-B mRNA was shown to be up-regulated by pressure, but not by mechanical stretch; close association with endoplasmic reticulum
- In temporal lobe epilepsy Nogo-A mRNA and immunoreactivity were markedly up-regulated in most neurons and their processes throughout the hippocampal formation.
- Expression of the genes encoding Nogo and its receptor, NgR, between weeks eight and 23 of human embryonic development
- Nogo CAA 3'UTR insertion polymorphism is not associated with schizophrenia or bipolar disorder
- There was a statistically significant difference at the allelic level for both the CAA (chi2 = 4.378, df = 1, P value = 0.036) and TATC (chi2 = 5.807, df = 1, P = 0.016) polymorphisms in the female subgroup.
- results identify Nogo-B as a new physiological substrate of MAPKAP-K2
- Nogo-A is possibly the best characterized of a variety of neurite growth inhibitors present in CNS myelin--REVIEW
- ASY/Nogo gene may act as a suppressor against adult T-cell leukemia/lymphoma progression, independent of Tax expression
- Reticulon proteins such as Nogo-A participate in the neuronal responses stemming from hippocampal formation during senescence, and particularly in Alzheimer disease .
- identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B
- identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B.
- Expressed in HEK293 cells, Nogo-C confers apoptosis by inducing caspase-3 and p53 activation through the c-jun N-terminal kinase-c-Jun-dependent pathway.
- Results describe the mapping of interaction domains mediating binding between BACE1 and RTN3/Nogo proteins.
- Nogo C to be overexpressed by 26% in the schizophrenia tissues And Nogo B was reduced by 17% in the frontal cortices who had severe depression.
- There is a direct correlation between the expression of Nogo A and C and the presence of alleles with a CAA insert in 3' UTR. New sample group shows Nogo C upregulation in schizophrenia and Nogo B downregulation in depression.
- Data show that the C-terminal of Nogo protein interacts with CX26.
- Soluble Nogo-A may be specific for the cerebrofinal fluid of patients with multiple sclerosis and may predict failure of axonal regeneration in the central nervous system.
- systematic substitution analysis of all 6 Cys residues of Nogo-A indicated that this domain forms 2 structural disulfide bonds among Cys residues 424, 464, 559 & 597, whereas the Cys residues at positions 699 & 912 seem to be dispensable for folding.
- The detection of Nogo-A in muscle biopsy samples from LMNS patients correctly identified patients who further progressed to ALS with 91% accuracy, 94% sensitivity, and 88% specificity.
- Nogo-A expression was negatively correlated with the malignancy grade of oligodendroglial tumors.
- The presence of Nogo-A in diseased human muscle biopsies is not limited to amyotrophic lateral sclerosis.
- Reduction of Nogo-B protein expression in thoracic aortic aneurysms is closely correlated to the formation of aneurysm and that Nogo-B may play a protective role in the pathological process of aneurysms.
- Accordingly, two novel mechanisms, A beta PP overexpression and ER stress, are involved in Nogo-B and Nogo-A expression in human muscle.
- Data is the first report to demonstrate the relationship between Nogo expression and heart failure, including cell-type specificity, in human HF and phenotypic rescue.
- Inhibition of integrin signaling by Amino-Nogo (nucleotide fragment 540-2592) contributes to the failure of central nervous system axon regeneration.
- A 25 kD band is detectable on Western blots stained with Nogo-A antibody in almost all CSF specimens, but is not likely to be a useful biomarker for multiple sclerosis.
- Nogo-a expression in glial CNS tumors may be a marker to differentiate between oligodendrogliomas and other gliomas.
- RTN4 allele (TATC)(2) and (TATC)(2)/(TATC)(2) genotype are associated with DCM.
- analysis of the interaction between ubiquitin ligase WWP1 and Nogo-A
- Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.