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Validated All-in-One™ qPCR Primer for PRMT6(NM_018137.3) Search again
Product ID:
HQP177403
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HRMT1L6
Gene Description:
protein arginine methyltransferase 6
Target Gene Accession:
NM_018137.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM].
Gene References into function
- methylates HIV-1 Tat protein and acts as a restriction factor for HIV-1 replication
- severely impairs the function of HIV-1 Rev binding to and export of viral RNA
- findings show HIV-1 Tat is a specific substrate of PRMT6 which targets Tat R52 & R53 residues for arginine methylation; PRMT6 can compromise Tat transcriptional activation & may represent a form of innate cellular immunity in regard to HIV-1 replication
- the arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H3R2me2a in vivo
- PRMT6 methylates H3R2 and is a negative regulator of N-terminal H3 tail binding
- findings identify PRMT6 as the mammalian methyltransferase for H3 R2 and establish the enzyme as a crucial negative regulator of H3 K4 trimethylation and transcriptional activation