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Validated All-in-One™ qPCR Primer for ATG16L1(NM_030803.7) Search again
Product ID:
HQP177167
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
APG16L, ATG16A, ATG16L, IBD10, WDR30
Gene Description:
autophagy related 16 like 1
Target Gene Accession:
NM_030803.7(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles.
Gene References into function
- Contains a coiled-coil domain and a motif with seven WD repeats, which are also shared by mouse Apg16L.
- A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
- The association of ATG16L1 with Crohn's disease and possibly with ulcerative colitis supports a role for autophagy in the pathogenesis of inflammatory bowel disease.
- No evidence of positive association of ATG16L1 with Crohn's disease was found in the Japanese population.
- we have replicated the association of allele G of rs2241880 in the ATG16L1 gene with Crohn's disease by demonstrating its effect in the childhood form of the disorder
- ATG16L1 T300A is strongly associated with Crohn's disease in New Zealand Caucasians with inflammatory bowel disease.
- ATG16L1 is significantly associated with Crohn disease.
- confirmed the association of IL23R and ATG16L1 with CD susceptibility and also the association of IL23R with UC. We found IL23R and ATG16L1 were not associated with celiac disease susceptibility.
- The ATG16L1 variant is associated with susceptibility to adult CD in Scotland, but not early-onset disease.
- ATG16L1 is a CD susceptibility gene without epistatic interaction
- No genotype-phenotype correlations were found among the Brazilian CD population with with ATG16L1.
- review of recent advances in genome-wide association studies of inflammatory bowel disease, with specific focus on growing evidence of the ATG16L1 gene's role in Crohn's disease [review]
- Rab33 modulates autophagosome formation through interaction with Atg16L
- ATG16L1 gene is asscociated with Crohn disease susceptibility in Hungarian patients.
- ATG16L1, IBD5, and IL23R SNPs were significantly associated with Crohn's Disease
- A greater than seven-fold increased CD risk was observed for current smokers with a GG genotype (vs nonsmoking AA genotype). A significant inverse association was found between T300A and UC. This was strongest for patients with extensive, severe disease.
- There is an association of IL23R polymorphisms with inflammatory bowel disease, and ATG16L1 with Crohn's disease, in both adult- and pediatric-onset subsets in our italian study population.
- ATG16L1 deficient Paneth cells exhibited notable abnormalities in the granule exocytosis pathway
- the association of ATG16L1*300A with increased risk of Crohn's disease is due to impaired bacterial handling and lowered rates of bacterial capture by autophagy.