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Validated All-in-One™ qPCR Primer for KCNK9(NM_001282534.2) Search again
Product ID:
HQP175068
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BIBARS, K2p9.1, KT3.2, TASK-3, TASK3, TASK32
Gene Description:
potassium two pore domain channel subfamily K member 9
Target Gene Accession:
NM_001282534.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains.
Gene References into function
- TASK-1 and TASK-3 differed insofar as a large portion of the C terminus was necessary for the full effects of halothane and TRH on TASK-3 but not on TASK-1
- Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation.
- results establish a direct link between the potassium channel activity of TASK3 and its oncogenic functions and imply that blockers for this potassium channel may have therapeutic potential for the treatment of cancers
- TASK3 is expressed in pia mater, astrocytes, Purkinje and granule cells
- TASK-3 channels underlie a major component of cerebellar granule neurons leak current which is sensitive to block by zinc
- Overexpression rather than mutation of the KCNK9 gene may contribute to the development of colorectal cancers.
- The expression pattern of TASK-3 in Melanoma cells is determined.
- (Glutamic acid-aspartic acid-glutamic acid) in human TASK-3 is a major determinant of the rate of endoplasmic reticulum export and is required for efficient surface expression of the channel.
- Kcnk9 is an inprinted gene playing an important role in apoptosis, tumorogenesis and neuronal development.
- TASK-3 channels are present in the mitochondria in both malignantly transformed and healthy cells, suggesting that they might have roles in ensuring mitochondrial functions.
- TASK3 channels may possibly represent a novel molecular target for the treatment of human glioblastoma
- K(2)P channels as novel potassium conductance on T lymphocytes critically influencing T cell effector function and identify a possible molecular target for immunomodulation in T cell-mediated autoimmune disorders
- the TASK3 M1P1 loop lies close to the pore, regulating TASK3 channel activity
- a mutation in the genomically imprinted potassium channel KCNK9 may have a role in the maternally inherited Birk Barel mental retardation dysmorphism syndrome
- Thus, regulated expression of TASK channels might contribute to a molecular switch between death and survival of neurons in autoimmune CNS inflammation.
- Both TASK-3 and TREK-1 are functionally operational in the adrenocortical H295R cell line, modulate membrane potential and aldosterone secretion.