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Validated All-in-One™ qPCR Primer for ASAP1(NM_018482.4) Search again
Product ID:
HQP174410
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P
Gene Description:
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Target Gene Accession:
NM_018482.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- DEF-1 alters cell motility through the deactivation of ARF1. In contrast, the inhibition of cell spreading by DEF-1 was not dependent on GAP activity, indicating that spreading and motility are altered by DEF-1 through different pathways.
- These results suggest that POB1 interacts with PAG2 through its proline-rich motif, thereby regulating cell migration (PAG2).
- involved in peripheral focal adhesions, directed by CRKL protein
- DDEF1 overexpression may be a pathogenetically relevant consequence of chromosome 8q amplification, which commonly occurs in high-grade uveal melanomas
- Results support a model that regulation of GAP (GTPase-activating protein) activity of ASAP1 involves conformational changes, coincident with recruitment to a membrane surface and following the specific binding of phosphatidylinositol 4,5-bisphosphate.
- Results suggest that the AMAP1/cortactin complex, which is not detected in normal mammary epithelial cells, is an excellent drug target for cancer therapeutics.
- ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
- study suggests that the ASAP1 gene plays a role in prostate cancer metastasis and may represent a therapeutic target and/or biomarker for metastatic disease
- ASAP1, like FIP3, functions as a component of the endocytic recycling compartment
- Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1