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Validated All-in-One™ qPCR Primer for ERVW-1(NM_014590.4) Search again
Product ID:
HQP174280
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV
Gene Description:
endogenous retrovirus group W member 1, envelope
Target Gene Accession:
NM_014590.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved.
Gene References into function
- Env HERV-W glycoprotein mediates cell-cell fusion upon interaction with the type D mammalian retrovirus receptor. Env protein was detected in the placental syncytiotrophoblast, suggesting a physiological role during pregnancy and placenta formation.
- contributor to normal placental architecture, especially in the fusion processes of cytotrophoblasts to syncytiotrophoblasts. the gene expression of syncytin may be altered in cases with placental dysfunction such as preeclampsia or HELLP syndrome.
- mRNA abundance for syncytin showed stimulation by forskolin in BeWo cells
- syncytin-mediated trophoblastic fusion in human cells is regulated by GCMa
- Syncytin gene activation is highest in term placenta
- HERV-W Env glycoprotein is directly involved in the differentiation of primary cultures of human villous cytotrophoblasts
- Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia.
- Syncytin gene expression is down-regulated by hypoxia, which strengthens the hypothesis that syncytin is reduced in disturbed pregnancies in the course of placental hypoxia.
- syncytin promoter is located in the 5' long terminal repeat (LTR) of the HERV-W gene and that binding sites for CBF and Oct in the proximal promoter are critical for transcriptional regulation of the gene in trophoblast cells.
- relative L1 and HERV-W expression levels are elevated in representative samples of malignant vs. non-malignant ovarian tissues
- Comparison of orthologous and paralogous (H)ERV-W elements demonstrated the selective preservation of the env gene of the ERVWE1 locus and identified specific traits underlying the process of evolution from a retroviral envelope toward a cellular gene
- Cytoplasmic domain of syncytin is not essential for syncytin-mediated fusion but may play regulatory role. Intramolecular interaction between two heptad repeat regions (HRA and B) is involved in fusion process.
- Syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention.
- control of env ERVWE1 placental expression in hominidae by the ERVWE1 retroviral LTR and a cellular trophoblast-specific-enhancer
- identification of the maturation requirements for env ERVWE1 fusion competence
- The 146-bp region of the 5'-flanking region (nt-294/-148) of the human syncytin gene acts as a placenta-specific enhancer.
- GCMa-driven syncytin expression is the key mechanism for syncytiotrophoblast formation
- Preservation in Hominoids of a genomic structure consisting in the juxtaposition of a retrotransposon-derived MaLR LTR (enhancer in hominidae) and the ERVWE1 provirus (promoter)
- Syncytin transcripts were found in first-trimester trophoblast cells with both villous and extravillous phenotypes and also in the JAR and JEG-3 choriocarcinoma cell lines.
- evaluation of the interaction of the HERV-W envelope with the hASCT2 receptor; a region consisting of the N-terminal 124 amino acids of the mature glycoprotein surface subunit was determined as the minimal receptor-binding domain
- Syncytin is expressed by human cancer cells and is involved in cancer-endothelial cell fusions
- Median viral RNA levels for syncytin-1 were higher in brains of MS patients relative to non-MS patients and median syncytin-1 DNA levels in MS brains were higher than non-MS brain tissue.
- Transcripts from the HERV-W element on chromosome 7q21.2 encoding syncytin and from the SOD1 gene were detected at elevated levels in biopsies from the most affected muscles from MND patients compared to biopsies from control individuals.
- present evidence in support of the direct role for syncytin-A in mouse trophoblast stem cell fusion and differentiation involved in placental dev.
- findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not
- Syncytins may represent universal fusogens in primates and rodents.