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Validated All-in-One™ qPCR Primer for USP22(NM_015276.2) Search again
Product ID:
HQP171293
(click here to view gene annotation page)
Species:
Human
Symbol:
Alias:
USP3L
Gene Description:
ubiquitin specific peptidase 22
Target Gene Accession:
NM_015276.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Altered mRNA expression is associated with therapy failure and death in patients multiple types of cancer.
- ATXN7L3, USP22, & ENY2 are required cofactors for full transcriptional activity by nuclear receptors. The deubiquitinase activity of TFTC/STAGA HAT counteracts heterochromatin silencing & is a positive cofactor for in vivo nuclear receptor activation.
- USP22 is a subunit of the SAGA transcriptional cofactor complex. It deubiquitylates histone H2B & is recruited to specific genes by activators like Myc. USP22 is needed for cell cycle progression.
- biochemical analysis of the substrate specificity of USP22 reveals that it deubiquitylates histone H2A in addition to H2B
