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Validated All-in-One™ qPCR Primer for STK38(NM_001305102.2) Search again
Product ID:
HQP169992
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
NDR, NDR1
Gene Description:
serine/threonine kinase 38
Target Gene Accession:
NM_001305102.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- NDR1 and NDR2 serine-threonine kinases are regulated by mob proteins
- an insert within the catalytic domain between subdomains VII and VIII is autoinhibitory, and the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition.
- The NDR1 and NDR2 kinases were incorporated into HIV-1 particles and were cleaved by the HIV-1 protease.
- In vivo activation of human NDR by membrane-bound hMOBs is dependent on their interaction and occurs solely at the membrane.
- These data indicate that NDR-driven centrosome duplication requires Cdk2 activity and that Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.
- phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1
- findings identify NDR1/2 as novel proapoptotic kinases and key members of the RASSF1A/MST1 signaling cascade