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Validated All-in-One™ qPCR Primer for PTP4A3(NM_032611.3) Search again
Product ID:
HQP169691
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
PRL-3, PRL-R, PRL3
Gene Description:
protein tyrosine phosphatase 4A3
Target Gene Accession:
NM_032611.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane.
Gene References into function
- Data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.
- PRL-3 is expressed in tumor metastasis and vasculature, regardless of the tumor source.
- presentation of the solution structure of PRL-3, the first structure of a PRL phosphatase. The structure places PRL phosphatases in the class of dual specificity phosphatases with closest structural homology to the VHR phosphatase
- human PRL-3 structure by NMR
- PRL-3 expression was up-regulated in human liver carcinoma compared with normal liver
- PRL-3 expression in colorectal cancers may contribute to the establishment of liver metastasis
- Elevated PRL-3 protein expression is associated with colorectal cancer metastasis
- PRL-3 phosphatase has a role in ovarian cancer growth
- identified integrin alpha1 as a PRL-3-interacting protein for the first time, and verified this physical association with pull-down and co-immunoprecipitation assays
- In tumor cells, PRL-3 mRNA levels varied markedly with high expression in SKNAS neuroblastoma, MCF-7 and BT474 breast carcinoma, Hep3B hepatocellular carcinoma, and HCT116 colon carcinoma.
- PRL-3 mRNA expression was significantly higher in malignant compared to benign breast tissue. The results suggest that PRL-3 might serve as a novel prognostic factor in breast cancer, which may help to predict an adverse disease outcome.
- results suggest that PRL-3 may serve as an unfavorable prognostic marker in breast cancer, especially for patients with node-negative diseases
- Injection of PRL-3-expressing CHO cells into nude mice to form local tumors resulted in the recruitment of host endothelial cells into the tumors and initiation of angiogenesis. PRL-3-expressing cells reduced IL-4 expression levels.
- PRL-3 expression may participate in the progression and metastasis of gastric carcinoma and might be a novel molecular marker for aggressive gastric cancer.
- Colonic adenocarcinoma cells have the ability to produce PTP4A1, PTP4a2, and PTP4A3, which may relate to the lymph node metastasis of colonic adenocarcinoma.
- down-regulation of the PRL-3 gene is important in lung cancer metastasis and provide a new hypothesis of lung cancer metastases
- PRL-3 is a gene product specifically expressed in malignant plasma cells and may have a role in migration of these cells.
- This is the first report of detecting PRL-3 expression in gliomas, especially in grades III and IV.
- The identification of Ezrin as a specific and direct cellular substrate of PRL-3, is reported.
- PRL3 has a role in the gene-specific translational control of Csk expression
- high expression of PRL-3 in the lymph node metastasis (LNM) of gastric cancer had a negative impact on the prognosis of the patients, and plays important roles in LNM of gastric cancer and the tumor growth
- Data show that PRL-3 is up-regulated in tumor tissue compared with corresponding noncancerous liver tissue, and suggest that PRL-3 plays a key role in the angiogenesis and invasion of hepatocellular carcinoma.
- PRL-1 and PRL-3 mRNAs may be involved in and used to predict the metastasis of esophageal squamous cell carcinoma. Possibility of using PRL-1 and PRL-3 as therapeutical target.
- liver metastasis by PRL-3 is putatively mediated through lymph node metastasis and elevated tumor markers in the serum and the PRL-3 expression may not represent a direct causative mechanism of liver metastasis.
- PRL-3 overexpression is a common event in stage III colorectal primary tumours that is further selected during liver dissemination. PRL-3 expression correlates with tumour aggressiveness and is a promising predictor of distant metastases.
- High expression of PRL-3 can promote growth of gastric cancer.
- phosphatase of regenerating liver-3 has a role in tumor progression in nasopharyngeal carcinoma
- PRL-3 may play an important role for the promotion of CRC cell migration and metastatic potential through direct KRT8 dephosphorylation
- Knockdown of PRL-3 significantly suppressed the proliferation of SGC7901 cells in vitro and tumor growth in vivo. PRL-3 plays a key role in the growth of gastric cancer.
- These results suggest that cellular localization of PRL-3 is highly correlated with its function in tumor metastasis.