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Validated All-in-One™ qPCR Primer for TXNIP(NM_006472.6) Search again
Product ID:
HQP168676
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ARRDC6, EST01027, HHCPA78, THIF, VDUP1
Gene Description:
thioredoxin interacting protein
Target Gene Accession:
NM_006472.6(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- overexpression of mRNA sensitized HeLa cells to paraquat
- association of induction with decreased mRNA levels in prostate cancer cells [thioredoxin-binding protein 2]
- VDUP1 is a novel antitumor gene which forms a transcriptional repressor complex
- VDUP1 could have a unique role in epidermis regulating the conversion of postmitotic cells to differentiating ones.
- VDUP1 is upregulated by heat shock factor during stresses such as high density and serum deprivation cultures
- reduced thioredoxin activity through interaction with Txnip is an important mechanism for vascular oxidative stress in diabetes mellitus
- TXNIP gene does not ply a major role in familial combined hyperlipidemia, or related traits.
- interaction of TBP-2 was specific to Rch1 among other importin alpha subfamilies
- thioredoxin binding protein-2 and redox-sensitive signaling regulate human osteoclast differentiation
- Data suggest that thioredoxin-interacting protein and thioredoxin are key components of biomechanical signal transduction and establish them as potentially novel regulators of tumor necrosis factor signaling and inflammation in endothelial cells.
- thioredoxin-interacting protein (TXNIP)is a novel proapoptotic beta-cell gene elevated in insulin resistance/diabetes and up-regulated by glucose through a unique carbohydrate response element
- findings indicate that txnip is a novel glucocorticoid-induced primary target gene involved in mediating glucocorticoid-induced apoptosis
- By Northern blot, we confirm hypoxia-induced expression of insulin-like growth factor binding protein 3 (igfbp3), thioredoxin-interacting protein (txnip), neuritin (nrn1).
- Txnip cysteines 63 and 247 are important for formation of a disulfide-linked complex with thioredoxin that inhibits thioredoxin's reducing activity
- identified two Txnip cysteines that are important for thioredoxin binding and showed that this interaction is consistent with a disulfide exchange reaction between oxidized Txnip and reduced thioredoxin
- first report to implicate TXNIP in Type 2 diabetes; effect of TXNIP on triglycerides is influenced by plasma glucose concentration, suggesting biological relevance of TXNIP variations may be particularly relevant in recurrent episodes of hyperglycaemia
- TXNIP regulates both insulin-dependent and insulin-independent pathways of glucose uptake in human skeletal muscle. Data suggests that TXNIP might play a key role in defective glucose homeostasis preceding overt type 2 diabetes mellitus.
- In response to glucose, increased level of TXNIP RNA is followed by increased level of protein that is associated with increasing levels of reactive oxygen species (ROS) and reduced thioredoxin activity in a metastatic breast cancer-derived cell line.
- Enhanced VDUP1 gene expression by PPARgamma agonist induces apoptosis in human macrophages.
- downregulation of TXNIP may be partly involved in the pathogenesis of ulcerative colitis, including inflammation and colitis-associated colon carcinogenesis.
- Results suggest that high glucose induces Txnip through a TGF-beta1-independent pathway.
- D-allose, a simple monosaccharide, may act to cause TXNIP induction and p27kip1 protein stabilization in tumor cells
- TXNIP is directly repressed by FOXO1a, modulating the cellular response to oxidative stress and affecting life span
- TXNIP is induced in response to hypoxia in a HIF-1alpha-dependent manner in pancreatic cancer cells, resulting in increased apoptosis and increased sensitivity to platinum anticancer therapy.
- These studies suggest a key role for MondoA:Mlx complexes in the adaptive transcriptional response to changes in extracellular glucose concentration and peripheral glucose uptake.
- These studies indicate that hnRNP G promotes the expression of Txnip and mediates its tumor-suppressive effect.
- Results show that inhibition of TXNIP protects against glucotoxic beta-cell apoptosis and therefore may represent a novel therapeutic approach to halt diabetes progression.
- stimulation of PPARalpha in human macrophages might reduce arterial inflammation through differential regulation of the Trx-1 and VDUP-1 gene expression
- TXNIP is involved in the antitumor activity of CD437.