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Validated All-in-One™ qPCR Primer for KAT5(NM_182710.3) Search again
Product ID:
HQP168445
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ESA1, HTATIP, HTATIP1, NEDFASB, PLIP, TIP, TIP60, ZC2HC5, cPLA2
Gene Description:
lysine acetyltransferase 5
Target Gene Accession:
NM_182710.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins.
Gene References into function
- Tip60 has histone acetyltransferase activity and effectively acetylates H2A, H3, and H4 but not H2B of core histone mixtures
- Tip60 enhances Bcl-3-p50 activated transcription through NF-kappa B binding sites
- Tip60 interacts with human interleukin-9 receptor alpha-chain and may act as an adaptor protein for molecules that are important for IL-9 signaling
- Tip60 inhibits activation of CREB protein by protein kinase A
- Androgen receptor, Tip60, and HDAC1 form a trimeric complex upon the endogenous AR-responsive PSA promoter, acetylation and deacetylation of the AR is an important mechanism for regulating transcriptional activity.
- gamma secretase cleavage of APP may contribute to Alzheimer's disease-related neurodegeneration [GAMMA SECRETASE]
- Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.
- Tip60 acetyltransferase activity is controlled by G(2)/M-dependent phosphorylation
- Tip60 interacts with the translocation E26 transforming-specific leukemia gene (TEL) and functions as a transcriptional co-repressor
- TIP60 has a role in contributing to histone acetylation in response to mitogenic signals
- Data show that NuA4 complexes, including Tip60 and its splice variant Tip60b/PLIP, are indeed present in human cells.
- HIV-1 Tat down-regulates telomerase activity in the nucleus of CD4-positive T-cells.
- E2F1-dependent recruitment of Tip60 to chromatin occurred in late G(1)
- Tip60 plays a double role in the p53 pathway: under normal growth conditions, Tip60 contributes to maintain a basal pool of p53 by interfering with its degradation; following DNA damage, Tip60 functions as p53 co-activator
- TIP60 acetylates c-myc oncoprotein and regulates its function by altering its rate of degradation.
- Results identify YL1 as a subunit of the TRRAP/TIP60 HAT complex, and also as a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP.
- We conclude that PLIP may cause cells to exit from the cell cycle after the S phase and may function as part of a G2/M checkpoint mechanism.
- Neutralization of Tip60 by HIV-1 Tat inhibits the apoptotic response of cells to a genotoxic treatment
- DNA damage induces the rapid acetylation of ATM, dependent on the Tip60 histone acetyltransferase; activation of Tip60 by DNA damage and the recruitment of the ATM-Tip60 complex to sites of DNA damage is independent of ATM's kinase activity.
- HAT cofactor Trrap and Tip60 HAT bind to the chromatin surrounding sites of DNA double-strand breaks (DSBs).The cells may use the same basic mechanism involving HAT complexes to regulate distinct cellular processes, such as transcription and DNA repair.
- Tip60 and p400 play distinct roles in DNA damage-induced apoptosis and underline the importance of the Tip60 complex and its regulation in the proper control of cell fate.
- ability of Tip60 to regulate the activation of both ATM and DNA-PKcs in response to DNA damage demonstrates that Tip60 is a key component of the DNA damage-signaling network
- Here, we describe how TIP60 is a multifunctional enzyme involved in multiple nuclear transactions[review]
- The activation of ATM/ATR/CHK signaling pathways contributes to this G2 checkpoint and highlight the interrelated roles of p14ARF and the Tip60 protein in the initiation of this DNA damage-signaling cascade.
- Authors hypothesize that the HIV-1 TaT interacting protein can fuse with the PDLIM7 protein and that the fusion proteins could be easily transduced through biological membranes and have biological activity.
- Tip60-dependent acetylation of p53 at K120 modulates the decision between cell-cycle arrest and apoptosis, and it reveals that the DNA-binding core domain is an important target for p53 regulation by posttranslational modifications.
- Notch1 intracellular domain plays the role of a negative regulator in AICD signaling via the disruption of the AICD-Fe65-Tip60 trimeric complex.
- Tip60 effects vary between different PLAGL2 target gene promoters, suggesting that Tip60 is a novel promoter-specific coactivator of PLAGL2.
- HTATIP acts as a negative regulator of NOTCH1 signaling by means of acetylation.
- Data suggest that the sequential acetylation and ubiquitination of H2AX by TIP60-UBC13 promote enhanced histone dynamics, which in turn stimulate a DNA damage response.
- in both mouse and human, Tip60 has a haplo-insufficient tumour suppressor activity that is independent from-but not contradictory with-its role within the ARF-p53 pathway
- Regulation of the subcellular localisation of Tat-interactive protein 60 kDa via phosphorylation provides a novel means of controlling Tat-interactive protein 60 kDa function.
- NPAT recruits the TRRAP-Tip60 complex to histone gene promoters to coordinate the transcriptional activation of multiple histone genes during the G(1)/S-phase transition
- ETV6 interacts with TIP60 through a 63 amino acids region located in the central domain of ETV6 between the pointed and the ets domain.
- Rev-erbbeta modulates the apoCIII gene expression by recruiting different transcription co-activator or co-repressor.
- HIV-1 Tat-interacting protein 60 (Tip60) as a novel positive regulator of PPARgamma transcriptional activity.
- a functional synergism between C/EBPalpha and HTATIP in myeloid differentiation
- chromatin remodeling protein, Tip60, interacts directly with the FANCD2 protein
- Study found that Tip60 is capable of selectively inhibiting the Mdm2-mediated conjugation of Nedd8 to p53, whereas it did not affect p53 ubiquitination; hence, the two different E3 ligase activities of Mdm2 can be regulated individually.
- Rvb1 is critical for the dephosphorylation of phospho-H2AX due to the role of Rvb1 in maintaining the histone acetyltransferase activity of Tip60/NuA4
- analysis of regulation of ATM activation by ATF2-dependent control of TIP60 stability and activity
- review of roles of cebpa and tip60 in genetics of leukemiogenesis
- HAT gene expression is required for cisplatin resistance and Clock and Tip60 regulate not only transcription, but also DNA repair, through periodic histone acetylation
- contribute to a functional linkage between TIP60 and p73beta through MDM2 in the transcriptional regulation of cellular apoptosis
- Tip60 enables ultraviolet rays (UV)-induced dna damage response (DDR) signaling even in the absence of p53, whereas preaccumulated p53 suppresses UV-induced DDR by reducing the levels of BRCA1.
- Myc recruits the Tip60/p400 complex to achieve a coordinated histone acetylation/exchange reaction at activated promoters.