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Validated All-in-One™ qPCR Primer for ABCC4(NM_001105515.3) Search again
Product ID:
HQP167882
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
MOAT-B, MOATB, MRP4
Gene Description:
ATP binding cassette subfamily C member 4
Target Gene Accession:
NM_001105515.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq].
Gene References into function
- The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.
- These findings indicate that a nucleotide transporter, such as MRP4, modulates the cellular response to ganciclovir and thus may influence not only the efficacy of antiviral therapy, but also prodrug-based gene therapy.
- Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11.
- Steroid and bile acid conjugates are substrates of this protein.
- MRP4 and MRP5 are low affinity cyclic nucleotide transporters that may at best function as overflow pumps, decreasing steep increases in cGMP levels under conditions where cGMP synthesis is strongly induced and phosphodiesterase activity is limiting
- the affinity of MRP4 and MRP5 for nucleotide-based substrates is low.
- MRP4 is not solely responsible for cisplatin resistance in small cell lung cancer
- MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
- MRP4 can mediate the efflux of reduced glutathione from hepatocytes into blood by cotransport with monoanionic bile salts.
- ABCC4 may play a role in the cellular extrusion of Phase II detoxification metabolites
- ATP-dependent cGMP transport codistributed with MRP4 detection in platelet subcellular fractions, with highest activities in the dense granule and plasma membrane fractions; altered distribution of MRP4 was observed in Hermansky-Pudlak syndrome platelets
- MRP4 exhibits substrate-stimulated ATP hydrolysis
- MRP4 may have a role in MYCN oncogene amplification and in drug resistance in neuroblastoma
- Plant flavonoids were able to reverse drug resistance in human cells transfected with ABCC4; direct inhibition of MRP4-mediated [3H]cGMP transport in inside-out vesicles prepared from human erythrocytes was observed.
- In cholestatic conditions, ABCC4 may become a key pathway for efflux of bile acids from hepatocytes into blood.
- Induction of MRP4 mediates resistance of Prostate cancer cells to nucleotide-based chemotherapeutic drugs.
- ABCC4/Abcc4 and ABCG2/Abcg2 have roles in cGMP transport
- cholestasis is one major determinant of human hepatic MRP4 expression
- Inhibition of renal uptake (via OAT3) and efflux processes (via MRP2 and MRP4) explains the possible sites of drug-drug interaction for methotrexate with probenecid and some NSAIDs, including their glucuronides.
- Results suggest that Bcrp and Mrp4 are partly involved in the luminal efflux of edaravone sulfate and edaravone glucuronide, respectively.
- MRP4 protein levels were induced three-fold in primary biliary cirrhosis, whereas mRNA levels remained unchanged.
- MRP-4 is induced by celecoxib in lung cancer cells
- New comprehensive substrate-screening method for ABC transporters allowed the identification of 18 new substrates for MRP4.
- The role of ABCC4 in the ATP-dependent efflux transport of leukotrienes B4 and C4 is shown in a number of different cell types.
- Mrp4 knockout mice are more prone to CFTR-mediated secretory diarrhea.
- Single nucleotide polymorphisms of ABCC4 were identified and selected nonsynonymous variants were functionally characterized.
- Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4) is reported.
- MRP4/ABCC4 is an androgen-regulated gene important in the progression to prostate cancer and may be a potential drug target.
- contributes to human DC migration toward the draining lymph nodes
- ABCC4 regulates cAMP-dependent signaling pathways and controls human SMC proliferation.
- Celecoxib upregulates MRP4 in colon cancer and results in lack of synergy with standard chemotherapy.
- These data establish NHERF1 as a major determinant of MRP4 trafficking to apical membranes of mammalian kidney cells.
- Gaboxadol could be taken up into the kidney by hOAT1 followed by glucuronidation and efflux of the conjugate into urine via MRP4.
- The existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport.