|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for OLIG2(NM_005806.4) Search again
Product ID:
HQP167793
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19
Gene Description:
oligodendrocyte transcription factor 2
Target Gene Accession:
NM_005806.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain.
Gene References into function
- Analysis of 180 primary, metastatic, and non-neural human tumors shows OLIG2 is highly expressed in all diffuse gliomas. Immunohistochemistry and microarray analyses demonstrate higher OLIG2 in anaplastic oligodendrogliomas versus glioblastomas.
- Overexpression of OLIG2 was not only found in oligodendroglioma samples and normal neural tissue but also in a wide spectrum of malignant cell lines including leukemia, non-small cell lung carcinoma, melanoma, and breast cancer cell lines.
- Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification.
- Transcriptional regulation of transgenic Olig2 is involved in segregation of motoneuron precursor neuroblasts in the developing mouse spinal cord.
- A novel function of OLIG2 is to suppress glial tumor cell growth via cyclin-dependent kinase inhibitor p27.
- Findings show a general requirement for Olig2 function in glial cell development and highlight further roles for Olig transcription factors in neural progenitor cells.
- Data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function.
- Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders.
- OLIG2 expression was predominant over ID2 expression in oligodendroglial tumors, while ID2 expression was predominant over OLIG2 expression in astrocytic tumors.
- No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-2 expression.
- IL-13Ralpha2 and Olig2 have been identified and confirmed to be interesting candidate genes whose differential expression likely plays a role in malignant progression of astrocytomas
- absence of OLIG2 mutation in three PMLD patients presenting with a phenotype characterized by severe hypomyelination and motor neuron dysfunction
- The SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population.
- OLIG2 suppresses the motile phenotype of glioblastoma cells by activating RhoA.
- We found that genetic polymorphisms in CNP (rs2070106) and OLIG2 (rs1059004 and
- analysis of Olig2 immunohistochemistry in microcystic areas might therefore be useful for the differential diagnosis of pilocytic astrocytoma and diffuse astrocytomas .
- Olig2-immunohistochemistry is useful and potentially more reliable than the epithelial membrane antigen-immunohistochemistry for the diagnosis of ependymoma
- Olig2-induced neural stem cell differentiation involves downregulation of Wnt pathway.