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Validated All-in-One™ qPCR Primer for ALYREF(NM_005782.4) Search again
Product ID:
HQP167740
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ALY, ALY/REF, BEF, REF, THOC4
Gene Description:
Aly/REF export factor
Target Gene Accession:
NM_005782.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq].
Gene References into function
- recruitment of the human TREX complex to spliced mRNA is not directly coupled to transcription, but is instead coupled to transcription indirectly through splicing
- suggest a central role for ALY in T-cell enhancer function and oncogene activation
- Increased TAP binding correlates with increased SF2/ASF binding, but not increased REF/Aly or Y14 binding.
- Aly is a physiological target of nuclear PI3K signaling, which regulates its subnuclear residency, cell proliferation, and mRNA export activities through nuclear Akt phosphorylation and phosphoinositide association.
- Adaptor Aly functions in the Tap-p15-mediated nuclear export of HSP70 mRNA.