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Validated All-in-One™ qPCR Primer for HDAC6(NM_001321230.2) Search again
Product ID:
HQP167404
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CPBHM, HD6, JM21, PPP1R90
Gene Description:
histone deacetylase 6
Target Gene Accession:
NM_001321230.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Gene References into function
- the C terminus of HDAC 6 is both necessary and sufficient for specific association with polyubiquitin
- Localized to chromosome Xp11.22-23, a region which is characterized by instability in several cancers and neurological disorders.
- studies showed that recombinant histone deacetylase 6 bound to protein phosphatase 1 catalytic subunit and provided new insight into mechanism by which deacetylase inhibitors elicited coordinate changes in cellular protein phosphorylation and acetylation
- Results indicate that the cytoplasmic localization for murine and human histone deacetylase 6 (HDAC6) is differentially regulated and suggest that the tetradecapeptide repeat domain serves as an important element to retain HDAC6 in the cytoplasm.
- HDAC6 mRNA expression may have potential both as a marker of endocrine responsiveness and also as a prognostic indicator in breast cancer
- HDAC6 expression was an independent prognostic indicator in breast cancer.These results indicate the biological significance of HDAC6 regulation via estrogen signaling.
- Results identify Hsp90 as a target of HDAC6 and suggest reversible acetylation as a unique mechanism that regulates Hsp90 chaperone complex activity in maturation of the glucocorticoid receptor.
- findings indicate that HDAC6 is also an HSP90 deacetylase
- These results demonstrate that HDAC6 plays a significant role in regulating HIV-1 infection and Env-mediated syncytia formation.
- HDAC6-dependent retrograde transport on microtubules is used by cells to increase the efficiency and selectivity of autophagic degradation of aggregated huntingtin
- HDAC6 has an important role in the chemotaxis of T-lymphocytes, which is independent of its tubulin deacetylase activity.
- HDAC6 inhibition yielded a decrease in microtubule dynamics that was sufficient to decrease focal adhesion turnover
- in addition to its role in microtubule-dependent cell motility, HDAC6 influences actin-dependent cell motility by altering the acetylation status of cortactin, which, in turn, changes the F-actin binding activity of cortactin
- Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
- findings identify HDAC6 as a central component of the stress response, and suggest that it coordinates the formation of stress granules (SGs) by mediating the motor-protein-driven movement of individual SG components along microtubules
- epidermal growth factor-induced nuclear localization of beta-catenin is regulated by HDAC6-dependent deacetylation and provide a new mechanism by which HDAC inhibitors prevent tumor growth
- Increasing evidence that HDAC6 plays a role in cancer cells and may be a target for drug development. HDAC6 is an estrogen-regulated gene that has prognostic significance in estrogen receptor (ER)-positive breast cancer cells[REVIEW]
- HDAC6 is a critical regulator of TGF-beta1 induced epithelial-mesenchymal transition and a potential therapeutic target against pathological epithelial-mesenchymal transition, a key event for tumor progression and fibrogenesis
- peroxiredoxin (Prx) I and Prx II are specific targets of HDAC6
- These findings establish HDAC6 as a tau-interacting protein and as a potential modulator of tau phosphorylation and accumulation.
- The mRNA stability factor HuR was shown to support ERBB2 transcript integrity, bind and endogenously associate with a conserved U-rich element within the ERBB2 transcript 3' UTR, and colocalize with HDAC6.
- The immunohistochemical expression of HDAC6 in cutaneous T-cell lymphoma
- Lower HDAC6 levels combined with decreased microtubule binding lead to increased tubulin acetylation in ethanol-treated cells.
- modulation of HDAC6 and the microtubule network can increase the efficiency of gene transfer.
- Results provide the first experimental evidence that a specific HDAC member is required for efficient oncogenic transformation
- Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway.
- A new binding partner of HDAC6, the ubiquitin-like modifier FAT10 was identified.
- The results suggest that HDAC6 acts as a sensor of proteasome inhibition and directs the trafficking of parkin by using different motor proteins.