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Validated All-in-One™ qPCR Primer for SLC23A2(NM_005116.6) Search again
Product ID:
HQP167289
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
NBTL1, SLC23A1, SVCT2, YSPL2
Gene Description:
solute carrier family 23 member 2
Target Gene Accession:
NM_005116.6(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq].
Gene References into function
- These findings suggest a mechanism of ascorbic acid uptake regulation whereby an alternative sodium-ascorbate cotransporter 2 (SVCT2) gene product inhibits transport through the two known ascorbic acid transporters.
- Functionally expressed in human endothelial cells and negatively regulated by inflammatory cytokines. May provide new insight into treatment of cardiovascular diseases with ascorbic acid.
- SVCT2 mediates the secondary active and concentrative transport of ascorbic acid in human chondrocytes
- Functionally, SVCT1 expression led to more transport activity from the apical membrane, while SVCT2 expression only increased the uptake under the condition when basolateral membrane was exposed.
- Findings link genetic variants in the vitamin C transporter gene SLC23A2 to spontaneous preterm birth.
- The promoter functionality of the two genomic regions of the hSVCT2 upstream of these alternative first exons in human Vascular Smooth Muscle Cells was tested.
- SVCT2 may switch between a number of states with characteristic properties, including an inactive conformation in the absence of Ca(2+)/Mg(2+)
- SVCT2 mRNA expression in human first-trimester chorionic villi but not in term placental tissue.
- SVCT2 expression can be regulated at the translational level by ascorbic acid and the redox state.
- SVCT1 is responsible for epidermal ascorbic acid supply, whereas SVCT2 mainly facilitates ascorbic acid transport in the dermal compartment
- The results suggest that uncharged His109 of hSVCT2, directly or indirectly, contributes to substrate binding through the hydrogen bond.
- all three proximal tubule segments expressed the transporter but the S3 segment had the highest expression; Ascorbic acid transport in these cells was regulated by a single kinetic component that depended on the sodium concentration, pH and temperature
- N-Glycosylation is therefore essential for SVCT2 functionality.
- estrogen receptor 1, vitamin C receptors SLC23A1 and SLC23A2, and matrix metalloproteinase MMP3 and MMP9 are associated with susceptibility to lymphoma
- For SLC23A2, overall, there was no colorectal adenoma association with haplotypes, but two SNPs located in intron 8 and exon 11 could be associated (odds ratio = 0.49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C).
- hSVCT2 protein and mRNA are expressed at higher levels in HepG2 cells and native human liver, and the cloned hSVCT2 promoter has more activity in HepG2 cells.