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Validated All-in-One™ qPCR Primer for IL1RL1(NM_016232.5) Search again
Product ID:
HQP165389
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
Gene Description:
interleukin 1 receptor like 1
Target Gene Accession:
NM_016232.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells.
Gene References into function
- T1/ST2 is the first member of the IL-1 receptor superfamily so far studied that is apparently unable to activate NF-kappaB
- the results suggest that the expression of ST2 suppressed the anchorage-independent growth and malignancy
- Soluble ST2, a marker for Th2 cytokine producing cells, is increased in sepsis and trauma patients.
- Interleukin-1 receptor-1 gene is associated with increased risk of helicobacter pylori infection but not with gastic cancer.
- The -26999A allele of ST2 is correlated with an increased risk for atopic dermatitis.
- IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells
- ST2 negatively regulates LPS-induced IL-6 production via the inhibition of IkappaB degradation in THP-1 cells
- ST2 reduced production of IL-4, IL-5, and IL-13 from IL-33-stimulated splenocytes. These results indicate that soluble ST2 acts as a negative regulator of Th2 cytokine production by the IL-33 signaling.
- We suggest that sST2 could be a potential marker of dengue infection, could be associated with severity or could play a role in the immune response in secondary dengue virus infection.
- Increased sST2 plasma concentrations are independently and strongly associated with one-year all-cause mortality in these patients.
- study provides suggestive evidence for associations of SNPs in the IL1RL1 gene and adjacently located family members IL18R1 and IL18RAP with asthma and atopy in 2 independent Dutch asthma populations
- ST2 concentrations are frequently elevated in acute pulmonary diseases and are markedly prognostic for death by 1 year.
- Human cord blood CD4-positive T cells, which are mainly comprised of naive cells, produce enhanced levels of interleukin (IL)-5 and IL-13 but not interferon-gamma or IL-4 when cultured with anti-CD3 antibody and IL-33, compared with anti-CD3 alone.
- Consistent with proposed role in myocardial-specific response to stretch, ST2 has strong clinical and biochemical correlates in patients with acute HF. Prognostically, ST2 is powerful in acute HF and is synergistic with natriuretic peptides for this use.
- Secretion of soluble ST2 - possible explanation for systemic immunosuppression after heart surgery.