|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for ZBTB17(NM_003443.3) Search again
Product ID:
HQP163215
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
MIZ-1, ZNF151, ZNF60, pHZ-67
Gene Description:
zinc finger and BTB domain containing 17
Target Gene Accession:
NM_003443.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq].
Gene References into function
- repression of p21 promoter/reporters as well as the endogenous p21 gene by Myc depends on interaction with Miz-1. Expression of Miz-1 increases during hematopoietic differentiation and Miz-1 activates the p21 promoter under conditions of low Myc levels
- Miz-1 has a role in inducing apoptosis along with MAGE-A4
- replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes
- Miz-1 targeting is essential for Myc-mediated apoptosis
- Miz-1 transcription factor was identified as an interactor of the SB transposase
- NDRG2 expression is repressed by Myc via Miz-1-dependent interaction with the NDRG2 core promoter
- repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction, which explains a copperative interaction between c-MYC and BCL2
- The crystal structure of the Miz-1 POZ domain show that the beta-sheet interface directs the tetramerisation of the Miz-1 POZ domain in solution.
- MIZ-1 is a new favorable neuroblastoma gene, which may directly or indirectly regulate the expression of other favorable neuroblastoma genes
- Gfi-1 does not directly bind to CDKN2B, but interacts with Miz-1 and, via Miz-1, is recruited to the core promoter of CDKN2B