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Validated All-in-One™ qPCR Primer for NR2E1(NM_003269.5) Search again
Product ID:
HQP162131
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
TLL, TLX, XTLL
Gene Description:
nuclear receptor subfamily 2 group E member 1
Target Gene Accession:
NM_003269.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- compared sequence from human, mouse, and the puffer fish Fugu rubripes
- Transgenic human NR2E1 was sufficient to fix structural brain & eye abnormalities & hyperaggressiveness in mice deleted for mouse Nr2e1. NR2E1 protein & regulatory sequences are comparable between these species.
- Strong purifying selection, low genetic diversity, 21 novel polymorphisms and five common haplotypes at were detected at NR2E1; protein-coding changes do not contribute to cortical and behavioral abnormalities, but regulatory mutations may play a role.
- we cannot exclude the possibility that deletions at NR2E1 may underlie MMEP, given that sequencing is unable to distinguish between homozygosity across loci versus large deletions
- TLX recruits histone deacetylases to repress transcription of p21(CIP1/WAF1) and pten and regulate neural stem cell proliferation
- Genetic variation at NR2E1 may be associated with susceptibility to brain-behavior disorders.
- LSD1 is a histone demethylase that is the prime corepressor for TLX