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Validated All-in-One™ qPCR Primer for TIA1(NM_022173.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Gene References into function
- apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing
- binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C
- Data suggest that TIA-1 functions as a translational silencer of cyclooxygenase-2 (COX-2) expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia.
- Increased TIA-1 gene expression is associated with sensitize endothelial cells to proapoptotic stimuli present in the tumor microenvironment and enhance NK cell cytotoxic activity against cancer cells in advanced soft tissue sarcoma
- data indicate that, in CFTR exon 9, TIA-1 binding to the polypyrimidine-rich controlling element recruits U1 small nuclear ribonucleoprotein to the weak 5'-ss and induces exon inclusion
- activated during HSV-1 infection and accumulated in cytoplasm of cells 6 hr after infection
- TIA-1 represses the translation of target transcripts.
- Results describe the gene expression of tristetraprolin, T-cell intracellular antigen and Hu antigen R in synovial tissues from rheumatoid arthritis and osteoarthritis patients.
- FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
- TIAR regulates the relative expression of TIA-1 isoforms.
- Cytotoxic molecule (CM) expression, specifically TIA1 and granzyme B, is predictive of prognosis in Hodgkin's-like anaplastic large cell lymphoma.
- dual role for TIA-1 in shuttling between DNA and RNA ligands to co-regulate COL2A1 expression at the level of transcription and pre-mRNA alternative splicing.
- Positive correlations between TIA1 protein gene expression in patients with rheumatoid and healthy persons.
- TIA-1-induced polysome disassembly is required for enhanced mRNA decay
- Simultaneous knockdown of TIA1 and TIAL1 resulted in increased skipping of alternatively spliced exons associated with U-rich motifs, but did not affect alternatively spliced exons that are not associated with U-rich motifs.
- Basophilic inclusions from patients with adult-onset atypical motor neuron disease were distinctly labeled with the antibodies against poly(A)-binding protein 1, T cell intracellular antigen 1, and ribosomal protein S6.
- These data demonstrated that TIA-1 inhibits HBsAg expression by interacting with the posttranscriptional regulatory element (PRE) of hepatitis B virus.
- Reults describe codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival.