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Validated All-in-One™ qPCR Primer for TGFB3(NM_001329939.2) Search again
Product ID:
HQP161958
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ARVD, ARVD1, LDS5, RNHF, TGF-beta3
Gene Description:
transforming growth factor beta 3
Target Gene Accession:
NM_001329939.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1.
Gene References into function
- PAI-1 gene activation by TNF-alpha apparently is yet to be defined for the location of the response element and/or the signaling pathway, while TGF-beta is the most important cytokine for PAI-1 transcriptional activation through its 5' proximal promoter.
- crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex
- downregulation of TGF-beta 3 expression found in pre-eclamptic umbilical cord may contribute to the abnormal structure and mechanical properties seen in these pathological umbilical cords
- TGF-beta1, TGF-beta2 and TGF-beta3 isoforms are produced by chondrosarcomas and could have a potential role as autocrine growth stimulators in these neoplasms
- present in diabetic foot ulcer
- TGFbeta3 may have a role in mediating progesterone- and progestogen-induced endometrial differentiation
- TGFbeta3 regulates GM-CSF induced human myelopoiesis
- determination of the importance of conformational entropy in the interaction of TGF-beta3 with the receptors
- children with active celiac disease have an altered expression of TGF-beta1 and TGF-beta3 in the small intestine
- The role of TGF-beta1 and -beta3 in generating a high TIFP was investigated in xenografted experimental anaplastic thyroid carcinoma (ATC) derived from the human ATC cell line
- investigated TGF-beta 1, -beta 2, and -beta 3 latency-associated peptides (LAP)expression in sound and carious human teeth
- TGF-beta3 expression in peritoneal fibroblasts was not affected by hypoxia or TGF-beta1 stimulation
- mutations make a contribution to clefts in South American populations
- positively associated with cleft lip and/or palate with hypodontia outside the cleft region
- Glucocorticoids significantly inhibited TGF-beta1 and TGF-beta2 production and reduced expression of the up-regulated TGF-beta1 and TGF-beta2 mRNA induced by exogenous TGF-beta1, -beta2, or -beta3
- All three TGF-beta isoforms have fibrogenic effects on renal cells. TGF-beta2 and TGF-beta3 effects may be partially mediated by TGF-beta1. Blockade of all isoforms together may yield best therapeutic effect in reducing renal fibrosis.
- NMR analysis of the extracellular domain of the human TGFbeta type II receptor in complex with monomeric TGFbeta3
- regulation of TGF-beta3 promoter activity by HIF-1 represents a mechanism for trophoblast differentiation during hypoxia.
- We identified TGFbeta3 as the disease gene involved in ARVD1.
- Human TGF-beta2 but not human TGF-beta1, or -beta3 promotes cardiac myocyte differentiation from mouse ES cells.
- TGF-beta 3 may promote endometrial tissue repair through the inhibition of the proliferation, expansion, and migration of endometrial stromal cells, and through stimulation of contraction of the collagen gel matrix by these cells.
- Depletion of TGFbeta3 from serum converts serum to a plasmalike reagent.
- Hunchback sequence binding protein may function as a TGF-beta3 gene transcriptional regulator and may be expressed in a cell type-specific manner.
- CD24 regulates E-cadherin and TGF-beta3 expression in cultured oral epithelial cells
- Altered crosstalk between RA, GABAergic, and TGF-beta signaling systems could be involved in human cleft palate fibroblast phenotype.
- BMP-2, TGF-beta2, and TGF-beta3 are involved in bone formation in heterotopic ossifications.
- TGF-beta3 may play a role as regulator of variety of cellular events during HELLP syndrome. High local expression may be responsible for remodeling of the placental structure resulting in dysfunction of maternal-fetal circulation.
- collagen I induces EMT in lung cancer cells by activating autocrine TGF-beta3 signaling. Epidermal growth factor also seems to initiate EMT via a TGF-dependent mechanism.
- TGF-beta2 and -beta3 are differentially expressed during the menstrual cycle and regulated by progesterone in epithelial vs stromal cells.
- There is a significantly elevated concentration of TGF-beta3 in PE eyes
- TGF-beta 3 is closely related to mineral maturation matrix in human developing teeth
- TGF-beta 3 was detected from the canalisation stage of the salivary gland, being weakly expressed on ductal cells, and it was the only factor detected on myoepithelial cells.
- oxygen regulates the placental expression of endoglin via TGF-beta 3
- TGF-beta complexes assemble cooperatively through recruitment of the low-affinity (type I) receptor by the ligand-bound high-affinity (type II) pair.
- Data support the involvement of TGFB3 in the development of oral clefts in patients among 204 triads of central European origin.
- study found different expression of the TGF-beta1, -2 and -3 isoforms in the human corneal epithelium; such differential expression of TGF-betas suggests that each of them may play a specific role in corneal tissue
- the TGF-beta1-2-3/Smad3 pathway has a role in mediating ovarian oncogenesis by enhancing metastatic potential
- Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription.
- the combination of daily loading and TGFbeta(3) administration produced superior osteocyte survival at the core centres when compared to loading or TGFbeta alone.
- Overexpression of TGF-beta3 and extracellular matrix proteins may represent antecedent tissue repair and therefore may be considered a significant event in the resolution of acquired reactive perforating collagenosis lesions